Clinical characteristics of chronic cutaneous graft-versus-host disease in Japanese leukemia patients after bone marrow transplantation: Low incidence and mild manifestations of skin lesions

H. Fujii, T. Hiketa, Y. Matsumoto, M. Ohashi, Y. Miyamura, M. Tanimoto, Y. Morishima, H. Saito, K. Horibe, Y. Shibata, K. Shimozato, M. Nakashima, K. Matsuyama, Yoshiki Akatsuka, Y. Kodera

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

We investigated the incidence of chronic graft-versus-host disease (GVHD) and skin and oral lesions in chronic GVHD in 90 Japanese leukemia patients surviving over 100 days after bone marrow transplantation (BMT) from HLA-compatible siblings. The clinical characteristics of chronic cutaneous GVHD occurring in eight of these patients are summarized. There were some differences from previous reports in the USA and Europe. The incidence (8/29: 28%) of skin lesions in chronic GVHD was low in contrast to the previously reported high incidence (79-90%). Cutaneous manifestations in six out of eight patients with chronic GVHD tended to be mild, and lichen-planus-like eruptions in the skin and scleroderma-like lesions, which are well known as representative cutaneous manifestations of chronic GVHD, were rare. Furthermore, our statistical analysis indicated that there was no relationship between pretransplant total body irradiation and GVHD prophylaxis or acute GVHD and the onset of chronic cutaneous GVHD. The present study suggests that the differences from previous reports in the USA and Europe concerning chronic cutaneous GVHD may be attributable to differing genetic backgrounds in Japanese and western populations.

Original languageEnglish
Pages (from-to)331-335
Number of pages5
JournalBone Marrow Transplantation
Volume10
Issue number4
Publication statusPublished - 01-01-1992
Externally publishedYes

Fingerprint

Skin Manifestations
Graft vs Host Disease
Bone Marrow Transplantation
Leukemia
Skin
Incidence
Lichen Planus
Whole-Body Irradiation
Siblings

All Science Journal Classification (ASJC) codes

  • Hematology
  • Transplantation

Cite this

Fujii, H. ; Hiketa, T. ; Matsumoto, Y. ; Ohashi, M. ; Miyamura, Y. ; Tanimoto, M. ; Morishima, Y. ; Saito, H. ; Horibe, K. ; Shibata, Y. ; Shimozato, K. ; Nakashima, M. ; Matsuyama, K. ; Akatsuka, Yoshiki ; Kodera, Y. / Clinical characteristics of chronic cutaneous graft-versus-host disease in Japanese leukemia patients after bone marrow transplantation : Low incidence and mild manifestations of skin lesions. In: Bone Marrow Transplantation. 1992 ; Vol. 10, No. 4. pp. 331-335.
@article{7459eeedf5f54a43a1f80f57961e66e7,
title = "Clinical characteristics of chronic cutaneous graft-versus-host disease in Japanese leukemia patients after bone marrow transplantation: Low incidence and mild manifestations of skin lesions",
abstract = "We investigated the incidence of chronic graft-versus-host disease (GVHD) and skin and oral lesions in chronic GVHD in 90 Japanese leukemia patients surviving over 100 days after bone marrow transplantation (BMT) from HLA-compatible siblings. The clinical characteristics of chronic cutaneous GVHD occurring in eight of these patients are summarized. There were some differences from previous reports in the USA and Europe. The incidence (8/29: 28{\%}) of skin lesions in chronic GVHD was low in contrast to the previously reported high incidence (79-90{\%}). Cutaneous manifestations in six out of eight patients with chronic GVHD tended to be mild, and lichen-planus-like eruptions in the skin and scleroderma-like lesions, which are well known as representative cutaneous manifestations of chronic GVHD, were rare. Furthermore, our statistical analysis indicated that there was no relationship between pretransplant total body irradiation and GVHD prophylaxis or acute GVHD and the onset of chronic cutaneous GVHD. The present study suggests that the differences from previous reports in the USA and Europe concerning chronic cutaneous GVHD may be attributable to differing genetic backgrounds in Japanese and western populations.",
author = "H. Fujii and T. Hiketa and Y. Matsumoto and M. Ohashi and Y. Miyamura and M. Tanimoto and Y. Morishima and H. Saito and K. Horibe and Y. Shibata and K. Shimozato and M. Nakashima and K. Matsuyama and Yoshiki Akatsuka and Y. Kodera",
year = "1992",
month = "1",
day = "1",
language = "English",
volume = "10",
pages = "331--335",
journal = "Bone Marrow Transplantation",
issn = "0268-3369",
publisher = "Nature Publishing Group",
number = "4",

}

Fujii, H, Hiketa, T, Matsumoto, Y, Ohashi, M, Miyamura, Y, Tanimoto, M, Morishima, Y, Saito, H, Horibe, K, Shibata, Y, Shimozato, K, Nakashima, M, Matsuyama, K, Akatsuka, Y & Kodera, Y 1992, 'Clinical characteristics of chronic cutaneous graft-versus-host disease in Japanese leukemia patients after bone marrow transplantation: Low incidence and mild manifestations of skin lesions', Bone Marrow Transplantation, vol. 10, no. 4, pp. 331-335.

Clinical characteristics of chronic cutaneous graft-versus-host disease in Japanese leukemia patients after bone marrow transplantation : Low incidence and mild manifestations of skin lesions. / Fujii, H.; Hiketa, T.; Matsumoto, Y.; Ohashi, M.; Miyamura, Y.; Tanimoto, M.; Morishima, Y.; Saito, H.; Horibe, K.; Shibata, Y.; Shimozato, K.; Nakashima, M.; Matsuyama, K.; Akatsuka, Yoshiki; Kodera, Y.

In: Bone Marrow Transplantation, Vol. 10, No. 4, 01.01.1992, p. 331-335.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Clinical characteristics of chronic cutaneous graft-versus-host disease in Japanese leukemia patients after bone marrow transplantation

T2 - Low incidence and mild manifestations of skin lesions

AU - Fujii, H.

AU - Hiketa, T.

AU - Matsumoto, Y.

AU - Ohashi, M.

AU - Miyamura, Y.

AU - Tanimoto, M.

AU - Morishima, Y.

AU - Saito, H.

AU - Horibe, K.

AU - Shibata, Y.

AU - Shimozato, K.

AU - Nakashima, M.

AU - Matsuyama, K.

AU - Akatsuka, Yoshiki

AU - Kodera, Y.

PY - 1992/1/1

Y1 - 1992/1/1

N2 - We investigated the incidence of chronic graft-versus-host disease (GVHD) and skin and oral lesions in chronic GVHD in 90 Japanese leukemia patients surviving over 100 days after bone marrow transplantation (BMT) from HLA-compatible siblings. The clinical characteristics of chronic cutaneous GVHD occurring in eight of these patients are summarized. There were some differences from previous reports in the USA and Europe. The incidence (8/29: 28%) of skin lesions in chronic GVHD was low in contrast to the previously reported high incidence (79-90%). Cutaneous manifestations in six out of eight patients with chronic GVHD tended to be mild, and lichen-planus-like eruptions in the skin and scleroderma-like lesions, which are well known as representative cutaneous manifestations of chronic GVHD, were rare. Furthermore, our statistical analysis indicated that there was no relationship between pretransplant total body irradiation and GVHD prophylaxis or acute GVHD and the onset of chronic cutaneous GVHD. The present study suggests that the differences from previous reports in the USA and Europe concerning chronic cutaneous GVHD may be attributable to differing genetic backgrounds in Japanese and western populations.

AB - We investigated the incidence of chronic graft-versus-host disease (GVHD) and skin and oral lesions in chronic GVHD in 90 Japanese leukemia patients surviving over 100 days after bone marrow transplantation (BMT) from HLA-compatible siblings. The clinical characteristics of chronic cutaneous GVHD occurring in eight of these patients are summarized. There were some differences from previous reports in the USA and Europe. The incidence (8/29: 28%) of skin lesions in chronic GVHD was low in contrast to the previously reported high incidence (79-90%). Cutaneous manifestations in six out of eight patients with chronic GVHD tended to be mild, and lichen-planus-like eruptions in the skin and scleroderma-like lesions, which are well known as representative cutaneous manifestations of chronic GVHD, were rare. Furthermore, our statistical analysis indicated that there was no relationship between pretransplant total body irradiation and GVHD prophylaxis or acute GVHD and the onset of chronic cutaneous GVHD. The present study suggests that the differences from previous reports in the USA and Europe concerning chronic cutaneous GVHD may be attributable to differing genetic backgrounds in Japanese and western populations.

UR - http://www.scopus.com/inward/record.url?scp=0026738038&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026738038&partnerID=8YFLogxK

M3 - Article

C2 - 1422488

AN - SCOPUS:0026738038

VL - 10

SP - 331

EP - 335

JO - Bone Marrow Transplantation

JF - Bone Marrow Transplantation

SN - 0268-3369

IS - 4

ER -