TY - JOUR
T1 - Clinical characteristics of nonobese patients with acute coronary syndrome and increased epicardial fat volume
AU - Harada, Ken
AU - Suzuki, Hitomi
AU - Matsunaga, Shun
AU - Onishi, Tomohiro
AU - Nishikawa, Yoshinori
AU - Funakubo, Hiroshi
AU - Mamiya, Kumiko
AU - Nagao, Tomoyuki
AU - Shinoda, Norihiro
AU - Sakai, Shinichi
AU - Kato, Masataka
AU - Marui, Nobuyuki
AU - Ishii, Hideki
AU - Amano, Tetsuya
AU - Matsubara, Tatsuaki
AU - Murohara, Toyoaki
N1 - Publisher Copyright:
© 2018 Japan Atherosclerosis Society.
PY - 2018
Y1 - 2018
N2 - Aim: Increased epicardial fat volume (EFV) is an independent risk factor for acute coronary syndrome (ACS). Although EFV increases with body mass index (BMI), some ACS patients have an increased EFV but normal BMI. We here investigated the clinical characteristics of nonobese ACS patients with an increased EFV. Methods: A total of 197 Japanese patients hospitalized for ACS was evaluated for EFV, abdominal visceral fat area (VFA), and lipid and glucose profiles. Control subjects comprised 141 individuals who were suspected of having ACS but whose coronary computed tomography findings were normal. Results: EFV was increased in ACS patients compared with control subjects (120±47 versus 95±45 mL, P＜ 0.01). ACS patients were divided into four groups based on average EFV (120 mL) and a BMI obesity cutoff of 25 kg/m 2 . For the 30 nonobese ACS patients with an above-average EFV, EFV was positively correlated with VFA (r =0.23, P =0.031). These individuals were significantly older (74±10 years) and tended to have a higher homeostasis model assessment – insulin resistance value (5.5±3.8) compared with other ACS patients. Among nonobese study subjects, EFV was independently associated with ACS (odds ratio=2.01, P =0.021) and correlated with abdominal circumference (r =0.26, P =0.017). Conclusion: Nonobese ACS patients with an increased EFV were elderly and tended to manifest insulin resistance. Measurement of EFV may prove informative for evaluation of ACS risk among elderly nonobese individuals with an increased abdominal girth.
AB - Aim: Increased epicardial fat volume (EFV) is an independent risk factor for acute coronary syndrome (ACS). Although EFV increases with body mass index (BMI), some ACS patients have an increased EFV but normal BMI. We here investigated the clinical characteristics of nonobese ACS patients with an increased EFV. Methods: A total of 197 Japanese patients hospitalized for ACS was evaluated for EFV, abdominal visceral fat area (VFA), and lipid and glucose profiles. Control subjects comprised 141 individuals who were suspected of having ACS but whose coronary computed tomography findings were normal. Results: EFV was increased in ACS patients compared with control subjects (120±47 versus 95±45 mL, P＜ 0.01). ACS patients were divided into four groups based on average EFV (120 mL) and a BMI obesity cutoff of 25 kg/m 2 . For the 30 nonobese ACS patients with an above-average EFV, EFV was positively correlated with VFA (r =0.23, P =0.031). These individuals were significantly older (74±10 years) and tended to have a higher homeostasis model assessment – insulin resistance value (5.5±3.8) compared with other ACS patients. Among nonobese study subjects, EFV was independently associated with ACS (odds ratio=2.01, P =0.021) and correlated with abdominal circumference (r =0.26, P =0.017). Conclusion: Nonobese ACS patients with an increased EFV were elderly and tended to manifest insulin resistance. Measurement of EFV may prove informative for evaluation of ACS risk among elderly nonobese individuals with an increased abdominal girth.
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U2 - 10.5551/jat.42663
DO - 10.5551/jat.42663
M3 - Article
C2 - 29386421
AN - SCOPUS:85055606873
SN - 1340-3478
VL - 25
SP - 1044
EP - 1052
JO - Journal of atherosclerosis and thrombosis
JF - Journal of atherosclerosis and thrombosis
IS - 10
ER -
