Clinical characteristics of peripheral venous catheter-associated gram-negative bloodstream infection among patients with malignancy

Toshiharu Sasaki, Sohei Harada, Shungo Yamamoto, Daisuke Ohkushi, Brian Hayama, Koichi Takeda, Kosuke Hoashi, Joji Shiotani, Kazumi Takehana, Yohei Doi

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Abstract

Purpose Previous studies have suggested that peripheral venous catheter is a significant source of gram-negative bacteraemia in patients with malignancy. We aimed to identify risk factors and develop a clinical prediction rule for the involvement of gram-negative organisms in peripheral venous catheter-associated bloodstream infections (PVC-BSIs) among patients with malignancy. Methods This retrospective cohort study was conducted at a 700-bed cancer hospital in Japan. Consecutive patients diagnosed with PVC-BSI based on clinical and microbiological criteria were included in this study. Based on clinical and microbiological characteristics of PVCBSIs in cancer patients, a logistic regression model for predicting gram-negative organisms as causative organisms in PVC-BSIs was then developed. Results Of the 99 patients included in our cohort, 60 patients (60.6%) had gram-negative PVC-BSIs. The median age of patients with PVC-BSIs was 67 years (interquartile range [IQR], 59-74 years), and the median Pitt bactearemia score was 1 (IQR, 0-3). The median duration of catherization was 5 days (IQR, 4-7 days) and 70 patients (70.7%) received peripheral parenteral nutrition that contained amino acids. On multivariable analysis, age .65 years (odds ratio [OR], 3.07; 95% confidence interval [CI], 1.10-8.62), showering (OR, 3.15; 95% CI, 1.07-9.26), Pitt bacteraemia score .2 points (OR, 6.96; 95% CI, 2.52-19.2), and use of peripheral parenteral nutrition (OR, 0.31; 95% CI, 0.10-0.98) were independent predictors for gram-negative PVC-BSIs among all PVC-BSIs. The simplified PVC-GN scores established to predict gram-negative PVC-BSIs had a optimism-corrected c-index of 0.775. Conclusion Gram-negative bacteria were more commonly responsible for PVC-BSI than Gram-positive bacteria among cancer patients in this cohort. Involvement of Gram-negative bacteria in PVC-BSIs could be predicted with readily available clinical variables.

Original languageEnglish
Article numbere0228396
JournalPloS one
Volume15
Issue number1
DOIs
Publication statusPublished - 01-01-2020

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All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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Sasaki, T., Harada, S., Yamamoto, S., Ohkushi, D., Hayama, B., Takeda, K., Hoashi, K., Shiotani, J., Takehana, K., & Doi, Y. (2020). Clinical characteristics of peripheral venous catheter-associated gram-negative bloodstream infection among patients with malignancy. PloS one, 15(1), [e0228396]. https://doi.org/10.1371/journal.pone.0228396