Clinical Characteristics of Primary HHV-6B Infection in Children Visiting the Emergency Room

Fumihiko Hattori, Yoshiki Kawamura, Kei Kozawa, Hiroki Miura, Misa Miyake, Akiko Yoshikawa, Masaru Ihira, Tetsushi Yoshikawa

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: This cohort study, based on the design of a prior study in the United States, was conducted to elucidate the clinical features of primary human herpesvirus-6B (HHV-6B) infection. METHODS: Between June 2014 and May 2016, febrile children younger than 5 years who visited the emergency room (ER) and underwent blood examination were enrolled in this study. RESULTS: Fifty-nine (12%) of the 491 patients were diagnosed with primary HHV-6B infection. The rates of both simple and complex febrile seizure were significantly higher in patients with primary HHV-6B infection than in those without (P < 0.001 and P = 0.008, respectively). The median age at primary HHV-6B infection was 15 months. Forty-seven (79.7%) of the 59 patients with primary HHV-6B infection were younger than 2-year-old. Clinical features were compared between HHV-6B-infected patients older and younger than 2 years. The frequency of apparent infection (exanthema subitum) was significantly higher in the younger patients (P = 0.01). The median leukocyte (P = 0.01) and lymphocyte (P < 0.001) counts in the patients older than 2 years were significantly lower than those in the younger patients. CONCLUSIONS: Primary HHV-6B infection accounted for 12% of ER visits. Secondary febrile seizures, in particular the complex type, were considered to be a major contributor to the disease burden of primary HHV-6B infection. The timing of primary HHV-6B infection occurred at older ages than in past reports, and the frequency of inapparent infection was higher in older patients.

Original languageEnglish
Pages (from-to)e248-e253
JournalThe Pediatric infectious disease journal
Volume38
Issue number10
DOIs
Publication statusPublished - 01-10-2019

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Human Herpesvirus 6
Herpesviridae Infections
Hospital Emergency Service
Febrile Seizures
Exanthema Subitum
Infection
Leukocytes
Cohort Studies
Fever
Lymphocytes

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)
  • Infectious Diseases

Cite this

Hattori, Fumihiko ; Kawamura, Yoshiki ; Kozawa, Kei ; Miura, Hiroki ; Miyake, Misa ; Yoshikawa, Akiko ; Ihira, Masaru ; Yoshikawa, Tetsushi. / Clinical Characteristics of Primary HHV-6B Infection in Children Visiting the Emergency Room. In: The Pediatric infectious disease journal. 2019 ; Vol. 38, No. 10. pp. e248-e253.
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abstract = "OBJECTIVE: This cohort study, based on the design of a prior study in the United States, was conducted to elucidate the clinical features of primary human herpesvirus-6B (HHV-6B) infection. METHODS: Between June 2014 and May 2016, febrile children younger than 5 years who visited the emergency room (ER) and underwent blood examination were enrolled in this study. RESULTS: Fifty-nine (12{\%}) of the 491 patients were diagnosed with primary HHV-6B infection. The rates of both simple and complex febrile seizure were significantly higher in patients with primary HHV-6B infection than in those without (P < 0.001 and P = 0.008, respectively). The median age at primary HHV-6B infection was 15 months. Forty-seven (79.7{\%}) of the 59 patients with primary HHV-6B infection were younger than 2-year-old. Clinical features were compared between HHV-6B-infected patients older and younger than 2 years. The frequency of apparent infection (exanthema subitum) was significantly higher in the younger patients (P = 0.01). The median leukocyte (P = 0.01) and lymphocyte (P < 0.001) counts in the patients older than 2 years were significantly lower than those in the younger patients. CONCLUSIONS: Primary HHV-6B infection accounted for 12{\%} of ER visits. Secondary febrile seizures, in particular the complex type, were considered to be a major contributor to the disease burden of primary HHV-6B infection. The timing of primary HHV-6B infection occurred at older ages than in past reports, and the frequency of inapparent infection was higher in older patients.",
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Clinical Characteristics of Primary HHV-6B Infection in Children Visiting the Emergency Room. / Hattori, Fumihiko; Kawamura, Yoshiki; Kozawa, Kei; Miura, Hiroki; Miyake, Misa; Yoshikawa, Akiko; Ihira, Masaru; Yoshikawa, Tetsushi.

In: The Pediatric infectious disease journal, Vol. 38, No. 10, 01.10.2019, p. e248-e253.

Research output: Contribution to journalArticle

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AU - Hattori, Fumihiko

AU - Kawamura, Yoshiki

AU - Kozawa, Kei

AU - Miura, Hiroki

AU - Miyake, Misa

AU - Yoshikawa, Akiko

AU - Ihira, Masaru

AU - Yoshikawa, Tetsushi

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N2 - OBJECTIVE: This cohort study, based on the design of a prior study in the United States, was conducted to elucidate the clinical features of primary human herpesvirus-6B (HHV-6B) infection. METHODS: Between June 2014 and May 2016, febrile children younger than 5 years who visited the emergency room (ER) and underwent blood examination were enrolled in this study. RESULTS: Fifty-nine (12%) of the 491 patients were diagnosed with primary HHV-6B infection. The rates of both simple and complex febrile seizure were significantly higher in patients with primary HHV-6B infection than in those without (P < 0.001 and P = 0.008, respectively). The median age at primary HHV-6B infection was 15 months. Forty-seven (79.7%) of the 59 patients with primary HHV-6B infection were younger than 2-year-old. Clinical features were compared between HHV-6B-infected patients older and younger than 2 years. The frequency of apparent infection (exanthema subitum) was significantly higher in the younger patients (P = 0.01). The median leukocyte (P = 0.01) and lymphocyte (P < 0.001) counts in the patients older than 2 years were significantly lower than those in the younger patients. CONCLUSIONS: Primary HHV-6B infection accounted for 12% of ER visits. Secondary febrile seizures, in particular the complex type, were considered to be a major contributor to the disease burden of primary HHV-6B infection. The timing of primary HHV-6B infection occurred at older ages than in past reports, and the frequency of inapparent infection was higher in older patients.

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