Clinical characterization of CA19-9 in patients with interstitial pneumonia showing pathological nonspecific interstitial pneumonia pattern

Yoshitaka Totani, Yuji Saito, Hiromi Miyachi, Yukiko Yoneda, Hideyasu Shimizu, Tami Hoshino, Masamichi Hayashi, Yasuhiro Uchiyama, Sumito Isogai, Kiyoshi Matsui, Yasushi Hashimoto, Masaya Umemoto, Fumihiko Sasaki, Mitsushi Okazawa, Hiroki Sakakibara

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Abstract

OBJECTIVE AND METHODS: To assess the clinical significance of CA19-9 in patients with interstitial pneumonia showing pathological nonspecific interstitial pneumonia (NSIP) pattern (IP/NSIP groups), we measured the levels of serum (n = 14) and bronchoalveolar lavage fluid (BALF, n = 10) CA19-9 in IP/NSIP groups. RESULT: The serum levels of CA19-9 did not correlate with the serum levels of LDH, of KL-6, or of SP-D or with the intensity of chest Ga-67 scintigraphy. There were no significant differences between the serum CA19-9 levels before therapy and those after therapy in improving patients. The levels of CA19-9 in fibrotic NSIP groups (serum:n = 7, 138.3 + /- 79.6 U/ml BALF: n = 5, 845.8 + /- 334.2 U/ml) were significantly higher than those in cellular NSIP groups (serum: n = 7, 12.8 +/-2.1 U/ml, BALF: n = 5, 40.8 +/- 16.2 U/ml). Immunohistochemical stains of CA19-9 showed the strong positivity in the bronchiolar epitheliums located in severe fibrotic lesions and the mucus within the lumens of microscopic honeycomb. The serum levels of CA19-9 were increased in both worsening patients. CONCLUSION: We speculated that the serum levels of CA19-9 may reflect the progression of lung fibrosis but not the disease activity in IP-NSIP groups.

Original languageEnglish
Pages (from-to)77-83
Number of pages7
JournalNihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
Volume43
Issue number2
Publication statusPublished - 02-2005

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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    Totani, Y., Saito, Y., Miyachi, H., Yoneda, Y., Shimizu, H., Hoshino, T., Hayashi, M., Uchiyama, Y., Isogai, S., Matsui, K., Hashimoto, Y., Umemoto, M., Sasaki, F., Okazawa, M., & Sakakibara, H. (2005). Clinical characterization of CA19-9 in patients with interstitial pneumonia showing pathological nonspecific interstitial pneumonia pattern. Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society, 43(2), 77-83.