Clinical course of human herpesvirus 6 infection in pediatric living donor liver transplantation

Toshihiro Yasui, Tatsuya Suzuki, Tetsushi Yoshikawa, Hiroshi Yatsuya, Yoshiki Kawamura, Hiroki Miura, Fujio Hara, Shunsuke Watanabe, Naoko Uga, Atsuki Naoe

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Differentiation between active and latent viral infection is critical for analysis of HHV-6-associated disease. HHV-6 infection has been associated with several clinical manifestations; however, the precise role of HHV-6 in pediatric LDLT remains unclear. This retrospective cohort study included 33 pediatric patients who received LDLT. All of the recipients were monitored for HHV-6 infection using viral isolation and real-time PCR. HHV-6 infection was observed in 14 of 33 (42.4%) recipients, and HHV-6B infection occurred within 2 weeks after LDLT in 10 of 14 (71.4%) recipients. HHV-6 was isolated from 10 of 33 (30.3%) recipients. Multivariate analysis showed that independent predictors of HHV-6B infection were age (OR 0.975; 95% CI 0.943-0.999; P =.041), PELD (OR 1.091; P =.038), and biliary atresia (OR 16.48; P =.035). The occurrence of unexplained fever was significantly higher in recipients with HHV-6B infection (11/14) compared with uninfected recipients (6/19) (P =.013). Additionally, ALT levels at 8 and 9 weeks after transplantation were significantly higher in the recipients with HHV-6B infection. Younger age, high MELD/PELD score, and biliary atresia as an underlying disease were identified as risk factors for viral infection.

Original languageEnglish
Article numbere13239
JournalPediatric Transplantation
Volume22
Issue number7
DOIs
Publication statusPublished - 01-11-2018

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Human Herpesvirus 6
Herpesviridae Infections
Living Donors
Liver Transplantation
Pediatrics
Virus Diseases
Infection
Biliary Atresia
Real-Time Polymerase Chain Reaction
Cohort Studies
Fever
Multivariate Analysis
Retrospective Studies
Transplantation

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Transplantation

Cite this

Yasui, Toshihiro ; Suzuki, Tatsuya ; Yoshikawa, Tetsushi ; Yatsuya, Hiroshi ; Kawamura, Yoshiki ; Miura, Hiroki ; Hara, Fujio ; Watanabe, Shunsuke ; Uga, Naoko ; Naoe, Atsuki. / Clinical course of human herpesvirus 6 infection in pediatric living donor liver transplantation. In: Pediatric Transplantation. 2018 ; Vol. 22, No. 7.
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abstract = "Differentiation between active and latent viral infection is critical for analysis of HHV-6-associated disease. HHV-6 infection has been associated with several clinical manifestations; however, the precise role of HHV-6 in pediatric LDLT remains unclear. This retrospective cohort study included 33 pediatric patients who received LDLT. All of the recipients were monitored for HHV-6 infection using viral isolation and real-time PCR. HHV-6 infection was observed in 14 of 33 (42.4{\%}) recipients, and HHV-6B infection occurred within 2 weeks after LDLT in 10 of 14 (71.4{\%}) recipients. HHV-6 was isolated from 10 of 33 (30.3{\%}) recipients. Multivariate analysis showed that independent predictors of HHV-6B infection were age (OR 0.975; 95{\%} CI 0.943-0.999; P =.041), PELD (OR 1.091; P =.038), and biliary atresia (OR 16.48; P =.035). The occurrence of unexplained fever was significantly higher in recipients with HHV-6B infection (11/14) compared with uninfected recipients (6/19) (P =.013). Additionally, ALT levels at 8 and 9 weeks after transplantation were significantly higher in the recipients with HHV-6B infection. Younger age, high MELD/PELD score, and biliary atresia as an underlying disease were identified as risk factors for viral infection.",
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Clinical course of human herpesvirus 6 infection in pediatric living donor liver transplantation. / Yasui, Toshihiro; Suzuki, Tatsuya; Yoshikawa, Tetsushi; Yatsuya, Hiroshi; Kawamura, Yoshiki; Miura, Hiroki; Hara, Fujio; Watanabe, Shunsuke; Uga, Naoko; Naoe, Atsuki.

In: Pediatric Transplantation, Vol. 22, No. 7, e13239, 01.11.2018.

Research output: Contribution to journalArticle

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T1 - Clinical course of human herpesvirus 6 infection in pediatric living donor liver transplantation

AU - Yasui, Toshihiro

AU - Suzuki, Tatsuya

AU - Yoshikawa, Tetsushi

AU - Yatsuya, Hiroshi

AU - Kawamura, Yoshiki

AU - Miura, Hiroki

AU - Hara, Fujio

AU - Watanabe, Shunsuke

AU - Uga, Naoko

AU - Naoe, Atsuki

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AB - Differentiation between active and latent viral infection is critical for analysis of HHV-6-associated disease. HHV-6 infection has been associated with several clinical manifestations; however, the precise role of HHV-6 in pediatric LDLT remains unclear. This retrospective cohort study included 33 pediatric patients who received LDLT. All of the recipients were monitored for HHV-6 infection using viral isolation and real-time PCR. HHV-6 infection was observed in 14 of 33 (42.4%) recipients, and HHV-6B infection occurred within 2 weeks after LDLT in 10 of 14 (71.4%) recipients. HHV-6 was isolated from 10 of 33 (30.3%) recipients. Multivariate analysis showed that independent predictors of HHV-6B infection were age (OR 0.975; 95% CI 0.943-0.999; P =.041), PELD (OR 1.091; P =.038), and biliary atresia (OR 16.48; P =.035). The occurrence of unexplained fever was significantly higher in recipients with HHV-6B infection (11/14) compared with uninfected recipients (6/19) (P =.013). Additionally, ALT levels at 8 and 9 weeks after transplantation were significantly higher in the recipients with HHV-6B infection. Younger age, high MELD/PELD score, and biliary atresia as an underlying disease were identified as risk factors for viral infection.

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