Clinical effectiveness of efinaconazole 10% solution for treatment of onychomycosis with longitudinal spikes

Shinichi Watanabe, Ken Iozumi, Masatoshi Abe, Yoshiko Ito, Takashi Uesugi, Takashi Onoduka, Ichiro Kato, Fumihiro Kato, Kazuo Kodama, Hidetoshi Takahashi, Osamu Takeda, Koki Tomizawa, Yasuki Tateishi, Mizue Fujii, Jun Mayama, Fumio Muramoto, Hidemi Yasuda, Kiyomitsu Yamanaka, Tsunao Oh-i, Hiroko KasaiRyoji Tsuboi, Naoko Hattori, Ryuji Maruyama, Tokuya Omi, Harunari Shimoyama, Ichiro Nakasu, Emiko Watanabe-Okada, Shuhei Nishimoto, Takashi Mochizuki, Masao Fukuzawa, Mariko Seishima, Kazumitsu Sugiura, Osamu Yamamoto, Masahisa Shindo, Hiroe Kiryu, Masahiro Kusuhara, Motoi Takenaka

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Onychomycosis with longitudinal spikes in the nail plate has been reported to be refractory to oral drugs as with dermatophytoma. We evaluated the efficacy of 10% efinaconazole solution in the treatment of onychomycosis with longitudinal spikes. Of the 223 subjects who were enrolled in a previous study, a post-hoc analysis of 82 subjects with longitudinal spikes was performed in this study. The opacity ratio of longitudinal spikes was decreased over time from 8.1 to 0.9 at the final assessment. In addition, the longitudinal spike disappearance rate increased early after the application to 81.7% at the final assessment. Therefore, 10% efinaconazole solution can be a first-line drug for longitudinal spikes, which have been regarded as refractory to oral drugs.

Original languageEnglish
Pages (from-to)1474-1481
Number of pages8
JournalJournal of Dermatology
Volume48
Issue number10
DOIs
Publication statusPublished - 10-2021

All Science Journal Classification (ASJC) codes

  • Dermatology

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