Clinical Effects of a Pectin-Containing Oligomeric Formula in Tube Feeding Patients: A Multicenter Randomized Clinical Trial

Michio Maruyama, Satoshi Goshi, Yasushige Kashima, Akihiro Mizuhara, Takashi Higashiguchi

Research output: Contribution to journalArticle

Abstract

Background: A pectin-containing oligomeric formula (POF) is a unique type of enteral formula that transforms from a liquid to a gel after reacting with gastric acid. Reports on its clinical effects have been limited. The present study was conducted to examine and verify the clinical effects of POF. Methods: The study subjects were 201 stable patients receiving intragastric tube feeding. They were randomized into 2 groups to receive either POF or a standard polymeric formula (SPF) as a control. The duration of observation was 1 week. Analyses were conducted for the incidence of predefined composite events, including diarrhea, defecation treatments, and other enteral nutrition (EN) management–related events. Results: Composite events occurred in 15 of 98 patients in the POF group and 30 of 100 patients in the SPF group, with a significantly lower incidence in the POF group compared with the SPF group (P = 0.011). In particular, diarrhea occurred in 2 patients in the POF group and 13 patients in the SPF group, with a significantly lower incidence in the POF group compared with the SPF group (P = 0.003). Conclusions: The results of this study suggest that POF is less likely to cause EN-related events, especially diarrhea, than SPF is.

Original languageEnglish
JournalNutrition in Clinical Practice
DOIs
Publication statusAccepted/In press - 01-01-2019

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Enteral Nutrition
Randomized Controlled Trials
Diarrhea
Incidence
Defecation
pectin
Gastric Acid
Small Intestine
Gels
Observation

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

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title = "Clinical Effects of a Pectin-Containing Oligomeric Formula in Tube Feeding Patients: A Multicenter Randomized Clinical Trial",
abstract = "Background: A pectin-containing oligomeric formula (POF) is a unique type of enteral formula that transforms from a liquid to a gel after reacting with gastric acid. Reports on its clinical effects have been limited. The present study was conducted to examine and verify the clinical effects of POF. Methods: The study subjects were 201 stable patients receiving intragastric tube feeding. They were randomized into 2 groups to receive either POF or a standard polymeric formula (SPF) as a control. The duration of observation was 1 week. Analyses were conducted for the incidence of predefined composite events, including diarrhea, defecation treatments, and other enteral nutrition (EN) management–related events. Results: Composite events occurred in 15 of 98 patients in the POF group and 30 of 100 patients in the SPF group, with a significantly lower incidence in the POF group compared with the SPF group (P = 0.011). In particular, diarrhea occurred in 2 patients in the POF group and 13 patients in the SPF group, with a significantly lower incidence in the POF group compared with the SPF group (P = 0.003). Conclusions: The results of this study suggest that POF is less likely to cause EN-related events, especially diarrhea, than SPF is.",
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Clinical Effects of a Pectin-Containing Oligomeric Formula in Tube Feeding Patients : A Multicenter Randomized Clinical Trial. / Maruyama, Michio; Goshi, Satoshi; Kashima, Yasushige; Mizuhara, Akihiro; Higashiguchi, Takashi.

In: Nutrition in Clinical Practice, 01.01.2019.

Research output: Contribution to journalArticle

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