TY - JOUR
T1 - Clinical Effects of a Pectin-Containing Oligomeric Formula in Tube Feeding Patients
T2 - A Multicenter Randomized Clinical Trial
AU - Maruyama, Michio
AU - Goshi, Satoshi
AU - Kashima, Yasushige
AU - Mizuhara, Akihiro
AU - Higashiguchi, Takashi
N1 - Funding Information:
The authors gratefully acknowledge all the medical institutions that participated in the study for their cooperation and all the members of Clinical Study Committee of Japanese Society of Parenteral and Enteral Nutrition.
Publisher Copyright:
© 2019 American Society for Parenteral and Enteral Nutrition
PY - 2020/6/1
Y1 - 2020/6/1
N2 - Background: A pectin-containing oligomeric formula (POF) is a unique type of enteral formula that transforms from a liquid to a gel after reacting with gastric acid. Reports on its clinical effects have been limited. The present study was conducted to examine and verify the clinical effects of POF. Methods: The study subjects were 201 stable patients receiving intragastric tube feeding. They were randomized into 2 groups to receive either POF or a standard polymeric formula (SPF) as a control. The duration of observation was 1 week. Analyses were conducted for the incidence of predefined composite events, including diarrhea, defecation treatments, and other enteral nutrition (EN) management–related events. Results: Composite events occurred in 15 of 98 patients in the POF group and 30 of 100 patients in the SPF group, with a significantly lower incidence in the POF group compared with the SPF group (P = 0.011). In particular, diarrhea occurred in 2 patients in the POF group and 13 patients in the SPF group, with a significantly lower incidence in the POF group compared with the SPF group (P = 0.003). Conclusions: The results of this study suggest that POF is less likely to cause EN-related events, especially diarrhea, than SPF is.
AB - Background: A pectin-containing oligomeric formula (POF) is a unique type of enteral formula that transforms from a liquid to a gel after reacting with gastric acid. Reports on its clinical effects have been limited. The present study was conducted to examine and verify the clinical effects of POF. Methods: The study subjects were 201 stable patients receiving intragastric tube feeding. They were randomized into 2 groups to receive either POF or a standard polymeric formula (SPF) as a control. The duration of observation was 1 week. Analyses were conducted for the incidence of predefined composite events, including diarrhea, defecation treatments, and other enteral nutrition (EN) management–related events. Results: Composite events occurred in 15 of 98 patients in the POF group and 30 of 100 patients in the SPF group, with a significantly lower incidence in the POF group compared with the SPF group (P = 0.011). In particular, diarrhea occurred in 2 patients in the POF group and 13 patients in the SPF group, with a significantly lower incidence in the POF group compared with the SPF group (P = 0.003). Conclusions: The results of this study suggest that POF is less likely to cause EN-related events, especially diarrhea, than SPF is.
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U2 - 10.1002/ncp.10392
DO - 10.1002/ncp.10392
M3 - Article
C2 - 31606903
AN - SCOPUS:85074031991
VL - 35
SP - 464
EP - 470
JO - Nutrition in Clinical Practice
JF - Nutrition in Clinical Practice
SN - 0884-5336
IS - 3
ER -