Abstract
Background: A pectin-containing oligomeric formula (POF) is a unique type of enteral formula that transforms from a liquid to a gel after reacting with gastric acid. Reports on its clinical effects have been limited. The present study was conducted to examine and verify the clinical effects of POF. Methods: The study subjects were 201 stable patients receiving intragastric tube feeding. They were randomized into 2 groups to receive either POF or a standard polymeric formula (SPF) as a control. The duration of observation was 1 week. Analyses were conducted for the incidence of predefined composite events, including diarrhea, defecation treatments, and other enteral nutrition (EN) management–related events. Results: Composite events occurred in 15 of 98 patients in the POF group and 30 of 100 patients in the SPF group, with a significantly lower incidence in the POF group compared with the SPF group (P = 0.011). In particular, diarrhea occurred in 2 patients in the POF group and 13 patients in the SPF group, with a significantly lower incidence in the POF group compared with the SPF group (P = 0.003). Conclusions: The results of this study suggest that POF is less likely to cause EN-related events, especially diarrhea, than SPF is.
| Original language | English |
|---|---|
| Journal | Nutrition in Clinical Practice |
| DOIs | |
| Publication status | Accepted/In press - 01-01-2019 |
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All Science Journal Classification (ASJC) codes
- Medicine (miscellaneous)
- Nutrition and Dietetics
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Clinical Effects of a Pectin-Containing Oligomeric Formula in Tube Feeding Patients : A Multicenter Randomized Clinical Trial. / Maruyama, Michio; Goshi, Satoshi; Kashima, Yasushige; Mizuhara, Akihiro; Higashiguchi, Takashi.
In: Nutrition in Clinical Practice, 01.01.2019.Research output: Contribution to journal › Article
TY - JOUR
T1 - Clinical Effects of a Pectin-Containing Oligomeric Formula in Tube Feeding Patients
T2 - A Multicenter Randomized Clinical Trial
AU - Maruyama, Michio
AU - Goshi, Satoshi
AU - Kashima, Yasushige
AU - Mizuhara, Akihiro
AU - Higashiguchi, Takashi
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Background: A pectin-containing oligomeric formula (POF) is a unique type of enteral formula that transforms from a liquid to a gel after reacting with gastric acid. Reports on its clinical effects have been limited. The present study was conducted to examine and verify the clinical effects of POF. Methods: The study subjects were 201 stable patients receiving intragastric tube feeding. They were randomized into 2 groups to receive either POF or a standard polymeric formula (SPF) as a control. The duration of observation was 1 week. Analyses were conducted for the incidence of predefined composite events, including diarrhea, defecation treatments, and other enteral nutrition (EN) management–related events. Results: Composite events occurred in 15 of 98 patients in the POF group and 30 of 100 patients in the SPF group, with a significantly lower incidence in the POF group compared with the SPF group (P = 0.011). In particular, diarrhea occurred in 2 patients in the POF group and 13 patients in the SPF group, with a significantly lower incidence in the POF group compared with the SPF group (P = 0.003). Conclusions: The results of this study suggest that POF is less likely to cause EN-related events, especially diarrhea, than SPF is.
AB - Background: A pectin-containing oligomeric formula (POF) is a unique type of enteral formula that transforms from a liquid to a gel after reacting with gastric acid. Reports on its clinical effects have been limited. The present study was conducted to examine and verify the clinical effects of POF. Methods: The study subjects were 201 stable patients receiving intragastric tube feeding. They were randomized into 2 groups to receive either POF or a standard polymeric formula (SPF) as a control. The duration of observation was 1 week. Analyses were conducted for the incidence of predefined composite events, including diarrhea, defecation treatments, and other enteral nutrition (EN) management–related events. Results: Composite events occurred in 15 of 98 patients in the POF group and 30 of 100 patients in the SPF group, with a significantly lower incidence in the POF group compared with the SPF group (P = 0.011). In particular, diarrhea occurred in 2 patients in the POF group and 13 patients in the SPF group, with a significantly lower incidence in the POF group compared with the SPF group (P = 0.003). Conclusions: The results of this study suggest that POF is less likely to cause EN-related events, especially diarrhea, than SPF is.
UR - http://www.scopus.com/inward/record.url?scp=85074031991&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85074031991&partnerID=8YFLogxK
U2 - 10.1002/ncp.10392
DO - 10.1002/ncp.10392
M3 - Article
C2 - 31606903
AN - SCOPUS:85074031991
JO - Nutrition in Clinical Practice
JF - Nutrition in Clinical Practice
SN - 0884-5336
ER -