TY - JOUR
T1 - Clinical Effects of a Pectin-Containing Oligomeric Formula in Tube Feeding Patients
T2 - A Multicenter Randomized Clinical Trial
AU - Maruyama, Michio
AU - Goshi, Satoshi
AU - Kashima, Yasushige
AU - Mizuhara, Akihiro
AU - Higashiguchi, Takashi
N1 - Publisher Copyright:
© 2019 American Society for Parenteral and Enteral Nutrition
PY - 2020/6/1
Y1 - 2020/6/1
N2 - Background: A pectin-containing oligomeric formula (POF) is a unique type of enteral formula that transforms from a liquid to a gel after reacting with gastric acid. Reports on its clinical effects have been limited. The present study was conducted to examine and verify the clinical effects of POF. Methods: The study subjects were 201 stable patients receiving intragastric tube feeding. They were randomized into 2 groups to receive either POF or a standard polymeric formula (SPF) as a control. The duration of observation was 1 week. Analyses were conducted for the incidence of predefined composite events, including diarrhea, defecation treatments, and other enteral nutrition (EN) management–related events. Results: Composite events occurred in 15 of 98 patients in the POF group and 30 of 100 patients in the SPF group, with a significantly lower incidence in the POF group compared with the SPF group (P = 0.011). In particular, diarrhea occurred in 2 patients in the POF group and 13 patients in the SPF group, with a significantly lower incidence in the POF group compared with the SPF group (P = 0.003). Conclusions: The results of this study suggest that POF is less likely to cause EN-related events, especially diarrhea, than SPF is.
AB - Background: A pectin-containing oligomeric formula (POF) is a unique type of enteral formula that transforms from a liquid to a gel after reacting with gastric acid. Reports on its clinical effects have been limited. The present study was conducted to examine and verify the clinical effects of POF. Methods: The study subjects were 201 stable patients receiving intragastric tube feeding. They were randomized into 2 groups to receive either POF or a standard polymeric formula (SPF) as a control. The duration of observation was 1 week. Analyses were conducted for the incidence of predefined composite events, including diarrhea, defecation treatments, and other enteral nutrition (EN) management–related events. Results: Composite events occurred in 15 of 98 patients in the POF group and 30 of 100 patients in the SPF group, with a significantly lower incidence in the POF group compared with the SPF group (P = 0.011). In particular, diarrhea occurred in 2 patients in the POF group and 13 patients in the SPF group, with a significantly lower incidence in the POF group compared with the SPF group (P = 0.003). Conclusions: The results of this study suggest that POF is less likely to cause EN-related events, especially diarrhea, than SPF is.
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U2 - 10.1002/ncp.10392
DO - 10.1002/ncp.10392
M3 - Article
C2 - 31606903
AN - SCOPUS:85074031991
SN - 0884-5336
VL - 35
SP - 464
EP - 470
JO - Nutrition in Clinical Practice
JF - Nutrition in Clinical Practice
IS - 3
ER -
