Clinical evaluation of bone marrow transplantation using total body irradiation and induction chemotherapy ; treatment results during twelve years at our hospital and some problems on the therapy

T. Kawamura, S. Koga, K. Kikukawa, M. Okamoto, H. Miyazaki, H. Kojima, K. Esaki

Research output: Contribution to journalArticlepeer-review

Abstract

We performed sixty patients with hematological malignancies the total body irradiation prior to bone marrow transplantation (TBI-BMT) from 1988 to 2000. We delivered our each patient hyperfractionated TBI consisting of 2 fractions of 3Gy per day for 2 consecutive days following induction chemotherapy. It proved that TBI-BMT was a valuable treatment method for hematological malignancies which have poor prognosis. About the cumulative survival rate, patients of first remission were better outcome than patients beyond second remission. However, the therapy remained some problems which were the prophylaxis of GVHD for HLA-matched unrelated recipients. And we have to consider a new maintenance procedure to prevent relapse from transplanted donor cell.

Original languageEnglish
Pages (from-to)1165-1170
Number of pages6
JournalJapanese Journal of Clinical Radiology
Volume45
Issue number10
Publication statusPublished - 01-01-2000

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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