Clinical Evaluation Of Sulbactam/Cefoperazone In The Field Of Obstetrics And Gynecology

Voshihiko Yabuki; Akihiro Asamoto; Tsutomu Hoshiba

doi:10.11553/antibiotics1968b.37.1973

Clinical Evaluation Of Sulbactam/Cefoperazone In The Field Of Obstetrics And Gynecology

Voshihiko Yabuki, Akihiro Asamoto, Tsutomu Hoshiba

Research output: Contribution to journal › Article › peer-review

Abstract

One or 2 grams of sulbactam/cefoperazone (SBT/CPZ) in 250 ml of 5% glucose solution was administered twice daily by drip infusion to 10 patients with female genital organ infections. The clinical effectiveness was seen in 8 patients but not in 2 patients associated with emergence of replaced organism or non-eradicated causative organism. Antibacterial activity of SBT/CPZ vs. CPZ in the 20 clinical isolates revealed that SBT/CPZ was 1 or 3 tubes superior to CPZ alone in the ²-lactamase producing organisms, but, 1 or 2 tubes inferior to CPZ in the ²-lactamase non-producing organisms. In 1 case increases in GOT and GPT, and in another increases in GOT and GPT, and a decrease in platelets were observed even though their degrees were mild.

Original language	English
Pages (from-to)	1973-1976
Number of pages	4
Journal	Japanese Journal of Antibiotics
Volume	37
Issue number	10
DOIs	https://doi.org/10.11553/antibiotics1968b.37.1973
Publication status	Published - 1984
Externally published	Yes

All Science Journal Classification (ASJC) codes

Microbiology (medical)
Pharmacology (medical)
Infectious Diseases

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.11553/antibiotics1968b.37.1973

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title = "Clinical Evaluation Of Sulbactam/Cefoperazone In The Field Of Obstetrics And Gynecology",

abstract = "One or 2 grams of sulbactam/cefoperazone (SBT/CPZ) in 250 ml of 5% glucose solution was administered twice daily by drip infusion to 10 patients with female genital organ infections. The clinical effectiveness was seen in 8 patients but not in 2 patients associated with emergence of replaced organism or non-eradicated causative organism. Antibacterial activity of SBT/CPZ vs. CPZ in the 20 clinical isolates revealed that SBT/CPZ was 1 or 3 tubes superior to CPZ alone in the ²-lactamase producing organisms, but, 1 or 2 tubes inferior to CPZ in the ²-lactamase non-producing organisms. In 1 case increases in GOT and GPT, and in another increases in GOT and GPT, and a decrease in platelets were observed even though their degrees were mild.",

author = "Voshihiko Yabuki and Akihiro Asamoto and Tsutomu Hoshiba",

year = "1984",

doi = "10.11553/antibiotics1968b.37.1973",

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journal = "Japanese Journal of Antibiotics",

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publisher = "Japan Antibiotics Research Association",

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AU - Yabuki, Voshihiko

AU - Asamoto, Akihiro

AU - Hoshiba, Tsutomu

PY - 1984

Y1 - 1984

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AB - One or 2 grams of sulbactam/cefoperazone (SBT/CPZ) in 250 ml of 5% glucose solution was administered twice daily by drip infusion to 10 patients with female genital organ infections. The clinical effectiveness was seen in 8 patients but not in 2 patients associated with emergence of replaced organism or non-eradicated causative organism. Antibacterial activity of SBT/CPZ vs. CPZ in the 20 clinical isolates revealed that SBT/CPZ was 1 or 3 tubes superior to CPZ alone in the ²-lactamase producing organisms, but, 1 or 2 tubes inferior to CPZ in the ²-lactamase non-producing organisms. In 1 case increases in GOT and GPT, and in another increases in GOT and GPT, and a decrease in platelets were observed even though their degrees were mild.

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Clinical Evaluation Of Sulbactam/Cefoperazone In The Field Of Obstetrics And Gynecology

Abstract

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