Clinical evaluation of 18F-fludeoxyglucose positron emission tomography/CT using point spread function reconstruction for nodal staging of colorectal cancer

Kazuya Kawashima, Kenichi Kato, Makiko Tomabechi, Mikaru Matsuo, Koki Otsuka, Kazuyuki Ishida, Ryuji Nakamura, Shigeru Ehara

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Objective: For patients with colorectal cancer, lymph node metastasis is a very important factor for prognostic and treatment determinations. Fluorine-18 fludeoxyglucose positron emission tomography/CT (18F-FDG-PET/CT) is among the useful tools for detecting lymph node metastasis. Recently, a new 18F-FDG-PET/CT reconstruction technique for improving spatial resolution and signaltonoise ratios, point spread function (PSF), has become available. We assessed the effect of PSF reconstruction on standardized uptake values and its diagnostic accuracy for lymph node staging in patients with colorectal cancer. Methods: Weretrospectively analysed records from patients with colorectal cancer who underwent 18F-FDG-PET/CT for pre-operative staging. All positron emission tomography CT (PET/CT) examinations were reconstructed using ordered subset expectation maximization (OSEM) and OSEM1PSF. We compared sensitivities, specificities, positive-predictive values (PPVs), negative-predictive values (NPVs) and accuracies of conventional PET/CT (reconstructed with OSEM) and PSF-PET/CT (reconstructed with OSEM1PSF) for identifying lymph node metastases. We also analysed the diagnostic confidence level on a 5-point scale. Results: With conventional PET/CT, the sensitivity, specificity, PPV, NPV and accuracy were 53.1%, 99.1%, 94.4%, 88.3% and 89.1%, respectively. With PSF PET/CT, the corresponding values were 65.6%, 99.1%, 95.4%, 91.2% and 91.8%, respectively. Conventional PET/CT and PSF PET/CT did not differ significantly in terms of N-stage definition (p50.125). However, the diagnostic confidence level of PSF PET/CT was significantly higher than that of conventional PET/CT (p < 0.01). Conclusion: PSF reconstruction might slightly increase sensitivity without impairing specificity. Moreover, this technique is expected to facilitate more confident radiological decisions when compared with conventional PET/CT. Advance in knowledge: This study demonstrates the clinical effectiveness of PSF PET/CT for lymph node staging in colorectal cancer.

Original languageEnglish
Article number20150938
JournalBritish Journal of Radiology
Volume89
Issue number1063
DOIs
Publication statusPublished - 2016
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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