Clinical evolution of AmpC-mediated ceftazidime-avibactam and cefiderocol resistance in enterobacter cloacae complex following exposure to cefepime

Ryan K. Shields; Alina Iovleva; Ellen G. Kline; Akito Kawai; Christi L. McElheny; Yohei Doi

doi:10.1093/cid/ciaa355

Clinical evolution of AmpC-mediated ceftazidime-avibactam and cefiderocol resistance in enterobacter cloacae complex following exposure to cefepime

Ryan K. Shields, Alina Iovleva, Ellen G. Kline, Akito Kawai, Christi L. McElheny, Yohei Doi

Microbiology

Research output: Contribution to journal › Article › peer-review

65 Citations (Scopus)

Abstract

We report 2 independent patients from whom carbapenem and ceftazidime-avibactam–resistant Enterobacter cloacae complex strains were identified. The ceftazidime-avibactam resistance was attributed to a 2–amino acid deletion in the R2 loop of AmpC β-lactamase, which concurrently caused resistance to cefepime and reduced susceptibility to cefiderocol, a novel siderophore cephalosporin.

Original language	English
Pages (from-to)	2713-2716
Number of pages	4
Journal	Clinical Infectious Diseases
Volume	71
Issue number	10
DOIs	https://doi.org/10.1093/cid/ciaa355
Publication status	Published - 15-11-2020

All Science Journal Classification (ASJC) codes

Microbiology (medical)
Infectious Diseases

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10.1093/cid/ciaa355

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title = "Clinical evolution of AmpC-mediated ceftazidime-avibactam and cefiderocol resistance in enterobacter cloacae complex following exposure to cefepime",

abstract = "We report 2 independent patients from whom carbapenem and ceftazidime-avibactam–resistant Enterobacter cloacae complex strains were identified. The ceftazidime-avibactam resistance was attributed to a 2–amino acid deletion in the R2 loop of AmpC β-lactamase, which concurrently caused resistance to cefepime and reduced susceptibility to cefiderocol, a novel siderophore cephalosporin.",

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AU - Kline, Ellen G.

AU - Kawai, Akito

AU - McElheny, Christi L.

AU - Doi, Yohei

PY - 2020/11/15

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AB - We report 2 independent patients from whom carbapenem and ceftazidime-avibactam–resistant Enterobacter cloacae complex strains were identified. The ceftazidime-avibactam resistance was attributed to a 2–amino acid deletion in the R2 loop of AmpC β-lactamase, which concurrently caused resistance to cefepime and reduced susceptibility to cefiderocol, a novel siderophore cephalosporin.

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Clinical evolution of AmpC-mediated ceftazidime-avibactam and cefiderocol resistance in enterobacter cloacae complex following exposure to cefepime

Abstract

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