@article{80d8864eba054c8db3ae7062d019d7c9,
title = "Clinical evolution of AmpC-mediated ceftazidime-avibactam and cefiderocol resistance in enterobacter cloacae complex following exposure to cefepime",
abstract = "We report 2 independent patients from whom carbapenem and ceftazidime-avibactam–resistant Enterobacter cloacae complex strains were identified. The ceftazidime-avibactam resistance was attributed to a 2–amino acid deletion in the R2 loop of AmpC β-lactamase, which concurrently caused resistance to cefepime and reduced susceptibility to cefiderocol, a novel siderophore cephalosporin.",
author = "Shields, {Ryan K.} and Alina Iovleva and Kline, {Ellen G.} and Akito Kawai and McElheny, {Christi L.} and Yohei Doi",
note = "Funding Information: A. I. is supported by the Physician-Scientist Institutional Award from the Burroughs Wellcome Fund awarded to the University of Pittsburgh. R. K. S. was supported by the National Institutes of Health (NIH) (grant numbers K08AI114883 and R03AI144636). Y. D. was supported by the NIH (grant numbers R01AI104895 and R21AI135522). Publisher Copyright: {\textcopyright} The Author(s) 2020.",
year = "2020",
month = nov,
day = "15",
doi = "10.1093/cid/ciaa355",
language = "English",
volume = "71",
pages = "2713--2716",
journal = "Clinical Infectious Diseases",
issn = "1058-4838",
publisher = "Oxford University Press",
number = "10",
}