Clinical evolution of AmpC-mediated ceftazidime-avibactam and cefiderocol resistance in enterobacter cloacae complex following exposure to cefepime

Ryan K. Shields; Alina Iovleva; Ellen G. Kline; Akito Kawai; Christi L. McElheny; Yohei Doi

doi:10.1093/cid/ciaa355

Clinical evolution of AmpC-mediated ceftazidime-avibactam and cefiderocol resistance in enterobacter cloacae complex following exposure to cefepime

Ryan K. Shields
, Alina Iovleva
, Ellen G. Kline
, Akito Kawai
, Christi L. McElheny
, Yohei Doi

Research output: Contribution to journal › Article › peer-review

81 Citations (Scopus)

Abstract

We report 2 independent patients from whom carbapenem and ceftazidime-avibactam–resistant Enterobacter cloacae complex strains were identified. The ceftazidime-avibactam resistance was attributed to a 2–amino acid deletion in the R2 loop of AmpC β-lactamase, which concurrently caused resistance to cefepime and reduced susceptibility to cefiderocol, a novel siderophore cephalosporin.

Original language	English
Pages (from-to)	2713-2716
Number of pages	4
Journal	Clinical Infectious Diseases
Volume	71
Issue number	10
DOIs	https://doi.org/10.1093/cid/ciaa355
Publication status	Published - 15-11-2020
Externally published	Yes

All Science Journal Classification (ASJC) codes

Microbiology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/cid/ciaa355

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title = "Clinical evolution of AmpC-mediated ceftazidime-avibactam and cefiderocol resistance in enterobacter cloacae complex following exposure to cefepime",

abstract = "We report 2 independent patients from whom carbapenem and ceftazidime-avibactam–resistant Enterobacter cloacae complex strains were identified. The ceftazidime-avibactam resistance was attributed to a 2–amino acid deletion in the R2 loop of AmpC β-lactamase, which concurrently caused resistance to cefepime and reduced susceptibility to cefiderocol, a novel siderophore cephalosporin.",

author = "Shields, \{Ryan K.\} and Alina Iovleva and Kline, \{Ellen G.\} and Akito Kawai and McElheny, \{Christi L.\} and Yohei Doi",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2020.",

year = "2020",

month = nov,

day = "15",

doi = "10.1093/cid/ciaa355",

language = "English",

volume = "71",

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AU - Shields, Ryan K.

AU - Iovleva, Alina

AU - Kline, Ellen G.

AU - Kawai, Akito

AU - McElheny, Christi L.

AU - Doi, Yohei

PY - 2020/11/15

Y1 - 2020/11/15

N2 - We report 2 independent patients from whom carbapenem and ceftazidime-avibactam–resistant Enterobacter cloacae complex strains were identified. The ceftazidime-avibactam resistance was attributed to a 2–amino acid deletion in the R2 loop of AmpC β-lactamase, which concurrently caused resistance to cefepime and reduced susceptibility to cefiderocol, a novel siderophore cephalosporin.

AB - We report 2 independent patients from whom carbapenem and ceftazidime-avibactam–resistant Enterobacter cloacae complex strains were identified. The ceftazidime-avibactam resistance was attributed to a 2–amino acid deletion in the R2 loop of AmpC β-lactamase, which concurrently caused resistance to cefepime and reduced susceptibility to cefiderocol, a novel siderophore cephalosporin.

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UR - https://www.scopus.com/pages/publications/85090992686#tab=citedBy

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M3 - Article

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JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

IS - 10

ER -

Clinical evolution of AmpC-mediated ceftazidime-avibactam and cefiderocol resistance in enterobacter cloacae complex following exposure to cefepime

Abstract

All Science Journal Classification (ASJC) codes

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