Clinical experience with chemoradiotherapy comprising S-1 plus low-dose cisplatin in a patient with stage IV anal cancer

Nobuhiro Nitori, Yutaro Kato, Ayu Kato, Tomoaki Deguchi, Akihiro Okada, Masayuki Kojima, Junko Kuroda, Tomohisa Kadomura, Eisuke Kubota, Nobuto Origuchi, Masato Fujisaki, Masaki Kitajima

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

We report a case of anal cancer in a 58-year-old woman who complained of narrow, bloody stools and anal pain. Physical examination revealed anal stenosis associated with a circular mass arising in the anal canal. Histological examination of biopsy specimens confirmed a diagnosis of moderately differentiated squamous cell carcinoma. Enhanced computed tomography revealed anal cancer invading the levator ani and the vagina, with lymph-node, multiple hepatic, and pulmonary metastases. The patient received two cycle of chemoradiotherapy with S-1 plus low-dose cisplatin with rest for 4 weeks, leading to complete response of the primary lesion and a partial response of the metastatic lesions. Each cycle included oral S-1 (120 mg/body; day1-21), cisplatin (10 mg/body; day1-5, 8-12) and radiotherapy (2 Gy/day; day 1-5, 8-12, 15-19). Adverse effects of treatment were mild perineal skin erosion and mild appetite loss, but no hematologic toxicity. Although the patient died 16 months after first admission, chemoradiotherapy with S-1 plus cisplatin is potentially effective for the management of advanced anal cancer.

Original languageEnglish
Pages (from-to)3983-3989
Number of pages7
JournalAnticancer research
Volume31
Issue number11
Publication statusPublished - 01-11-2011
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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