Clinical features and testicular morphology in patients with Kallmann syndrome

Hidenori Nishio; Kentaro Mizuno; Yoshinobu Moritoki; Hideyuki Kamisawa; Yoshiyuki Kojima; Haruo Mizuno; Kenjiro Kohri; Yutaro Hayashi

doi:10.1016/j.urology.2011.10.032

Clinical features and testicular morphology in patients with Kallmann syndrome

Hidenori Nishio, Kentaro Mizuno, Yoshinobu Moritoki, Hideyuki Kamisawa, Yoshiyuki Kojima, Haruo Mizuno, Kenjiro Kohri, Yutaro Hayashi

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Kallmann syndrome (KS) is a genetic disorder characterized by the simultaneous occurrence of idiopathic hypogonadotropic hypogonadism (IHH) and anosmia. Here, we present 3 cases of KS with detailed description. In Case 1, testicular morphology was examined by testicular biopsy, and Leydig cells were examined by immunohistochemistry using antibodies against Ad4BP/SF1. Contrary to our predictions, the present study revealed the presence of Leydig cells in the testis. Testicular morphology in the patients with KS is more varied than expected, and further investigation is required to elucidate hormonal effects on normal testicular development.

Original language	English
Pages (from-to)	684-686
Number of pages	3
Journal	Urology
Volume	79
Issue number	3
DOIs	https://doi.org/10.1016/j.urology.2011.10.032
Publication status	Published - 03-2012
Externally published	Yes

All Science Journal Classification (ASJC) codes

Urology

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title = "Clinical features and testicular morphology in patients with Kallmann syndrome",

abstract = "Kallmann syndrome (KS) is a genetic disorder characterized by the simultaneous occurrence of idiopathic hypogonadotropic hypogonadism (IHH) and anosmia. Here, we present 3 cases of KS with detailed description. In Case 1, testicular morphology was examined by testicular biopsy, and Leydig cells were examined by immunohistochemistry using antibodies against Ad4BP/SF1. Contrary to our predictions, the present study revealed the presence of Leydig cells in the testis. Testicular morphology in the patients with KS is more varied than expected, and further investigation is required to elucidate hormonal effects on normal testicular development.",

author = "Hidenori Nishio and Kentaro Mizuno and Yoshinobu Moritoki and Hideyuki Kamisawa and Yoshiyuki Kojima and Haruo Mizuno and Kenjiro Kohri and Yutaro Hayashi",

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T1 - Clinical features and testicular morphology in patients with Kallmann syndrome

AU - Nishio, Hidenori

AU - Mizuno, Kentaro

AU - Moritoki, Yoshinobu

AU - Kamisawa, Hideyuki

AU - Kojima, Yoshiyuki

AU - Mizuno, Haruo

AU - Kohri, Kenjiro

AU - Hayashi, Yutaro

PY - 2012/3

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N2 - Kallmann syndrome (KS) is a genetic disorder characterized by the simultaneous occurrence of idiopathic hypogonadotropic hypogonadism (IHH) and anosmia. Here, we present 3 cases of KS with detailed description. In Case 1, testicular morphology was examined by testicular biopsy, and Leydig cells were examined by immunohistochemistry using antibodies against Ad4BP/SF1. Contrary to our predictions, the present study revealed the presence of Leydig cells in the testis. Testicular morphology in the patients with KS is more varied than expected, and further investigation is required to elucidate hormonal effects on normal testicular development.

AB - Kallmann syndrome (KS) is a genetic disorder characterized by the simultaneous occurrence of idiopathic hypogonadotropic hypogonadism (IHH) and anosmia. Here, we present 3 cases of KS with detailed description. In Case 1, testicular morphology was examined by testicular biopsy, and Leydig cells were examined by immunohistochemistry using antibodies against Ad4BP/SF1. Contrary to our predictions, the present study revealed the presence of Leydig cells in the testis. Testicular morphology in the patients with KS is more varied than expected, and further investigation is required to elucidate hormonal effects on normal testicular development.

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