TY - JOUR
T1 - Clinical features and testicular morphology in patients with Kallmann syndrome
AU - Nishio, Hidenori
AU - Mizuno, Kentaro
AU - Moritoki, Yoshinobu
AU - Kamisawa, Hideyuki
AU - Kojima, Yoshiyuki
AU - Mizuno, Haruo
AU - Kohri, Kenjiro
AU - Hayashi, Yutaro
N1 - Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.
PY - 2012/3
Y1 - 2012/3
N2 - Kallmann syndrome (KS) is a genetic disorder characterized by the simultaneous occurrence of idiopathic hypogonadotropic hypogonadism (IHH) and anosmia. Here, we present 3 cases of KS with detailed description. In Case 1, testicular morphology was examined by testicular biopsy, and Leydig cells were examined by immunohistochemistry using antibodies against Ad4BP/SF1. Contrary to our predictions, the present study revealed the presence of Leydig cells in the testis. Testicular morphology in the patients with KS is more varied than expected, and further investigation is required to elucidate hormonal effects on normal testicular development.
AB - Kallmann syndrome (KS) is a genetic disorder characterized by the simultaneous occurrence of idiopathic hypogonadotropic hypogonadism (IHH) and anosmia. Here, we present 3 cases of KS with detailed description. In Case 1, testicular morphology was examined by testicular biopsy, and Leydig cells were examined by immunohistochemistry using antibodies against Ad4BP/SF1. Contrary to our predictions, the present study revealed the presence of Leydig cells in the testis. Testicular morphology in the patients with KS is more varied than expected, and further investigation is required to elucidate hormonal effects on normal testicular development.
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U2 - 10.1016/j.urology.2011.10.032
DO - 10.1016/j.urology.2011.10.032
M3 - Article
C2 - 22173178
AN - SCOPUS:84857911559
VL - 79
SP - 684
EP - 686
JO - Urology
JF - Urology
SN - 0090-4295
IS - 3
ER -