TY - JOUR
T1 - Clinical features of breast cancer patients with human T-cell lymphotropic virus type-1 infection
AU - Hirata, Munetsugu
AU - Shinden, Yoshiaki
AU - Nagata, Ayako
AU - Nomoto, Yuki
AU - Saho, Hazuki
AU - Nakajo, Akihiro
AU - Arigami, Takaaki
AU - Kurahara, Hiroshi
AU - Maemura, Kosei
AU - Natsugoe, Shoji
AU - Kijima, Yuko
N1 - Publisher Copyright:
© 2019, Asian Pacific Organization for Cancer Prevention.
PY - 2019/6/1
Y1 - 2019/6/1
N2 - Background: Human T-cell lymphotropic virus type 1 (HTLV-1) is a retrovirus that causes adult T-cell leukemia/lymphoma (ATL), an aggressive form of T-cell malignancy. The relationship between HTLV-1 infection and cancer progression is controversial. HTLV-1 encodes oncogenic protein TAX1 and it is hypothesized that HTLV-1 infection is associated with breast cancer progression. In this study, we evaluated the relationship between HTLV-1 infection and clinicopathological factors in breast cancer patients. Methods: We retrospectively analyzed 610 patients with primary breast cancer who underwent surgical treatment without preoperative chemotherapy at Kagoshima University Hospital between January 2001 and January 2015. Results: When patients with and without HTLV-1 infection were compared, no differences in clinicopathological factors were observed, except for age. Disease-free survival and overall survival rates did not differ between groups. Conclusions: HTLV-1-positive patients were significantly older than HTLV-1-negative patients. It was supposed to be due to the fact that the HTLV-1 infection rate is decreasing. Any effect of HTLV-1 infection on breast cancer progression appears to be negligibly small.
AB - Background: Human T-cell lymphotropic virus type 1 (HTLV-1) is a retrovirus that causes adult T-cell leukemia/lymphoma (ATL), an aggressive form of T-cell malignancy. The relationship between HTLV-1 infection and cancer progression is controversial. HTLV-1 encodes oncogenic protein TAX1 and it is hypothesized that HTLV-1 infection is associated with breast cancer progression. In this study, we evaluated the relationship between HTLV-1 infection and clinicopathological factors in breast cancer patients. Methods: We retrospectively analyzed 610 patients with primary breast cancer who underwent surgical treatment without preoperative chemotherapy at Kagoshima University Hospital between January 2001 and January 2015. Results: When patients with and without HTLV-1 infection were compared, no differences in clinicopathological factors were observed, except for age. Disease-free survival and overall survival rates did not differ between groups. Conclusions: HTLV-1-positive patients were significantly older than HTLV-1-negative patients. It was supposed to be due to the fact that the HTLV-1 infection rate is decreasing. Any effect of HTLV-1 infection on breast cancer progression appears to be negligibly small.
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U2 - 10.31557/APJCP.2019.20.6.1909
DO - 10.31557/APJCP.2019.20.6.1909
M3 - Article
C2 - 31244317
AN - SCOPUS:85068929316
SN - 1513-7368
VL - 20
SP - 1909
EP - 1912
JO - Asian Pacific Journal of Cancer Prevention
JF - Asian Pacific Journal of Cancer Prevention
IS - 6
ER -