Clinical features of infants with primary human herpesvirus 6 infection (exanthem subitum, roseola infantum)

Y. Asano, T. Yoshikawa, S. Suga, I. Kobayashi, T. Nakashima, T. Yazaki, Y. Kajita, T. Ozaki

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164 Citations (Scopus)


Objective. To clarify clinical features of patients with primary human herpesvirus 6 (HHV-6) infection (roseola infantum, exanthem subitum) in a large-scale study. Subjects and methods. Clinical signs and symptoms were analyzed in 176 infants in whom exanthem subitum was initially suspected and primary HHV-6 infection was later confirmed. The infection was proved by isolation of the virus from blood, a significant increase in the neutralizing antibody titers to the virus, or both. Results. The primary HHV-6 infection, which occurred throughout the year, was observed in 94 boys and 82 girls (mean age, 7.3 months). Fever developed in 98% (mean maximum fever, 39.4°C) and lasted for 4.1 days. Macular or papular rashes appeared in 98%, on face, trunk, or both, mostly at the time of subsidence of the fever, and lasted for 3.8 days. Other clinical manifestations occurred as follows: mild diarrhea in 68%, edematous eyelids in 30%, erythematous papules in the pharynx in 65%, cough in 50%, and mild cervical lymph node swelling in 31%. Twenty-six percent had bulging of the anterior fontanelle and 8% had convulsions. Conclusions. Clinical features of patients with virologically confirmed exanthem subitum were comparable with those described before discovery of HHV-6.

Original languageEnglish
Pages (from-to)104-108
Number of pages5
Issue number1
Publication statusPublished - 1994

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health


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