Clinical features of infants with primary human herpesvirus 6 infection (exanthem subitum, roseola infantum)

Y. Asano, Tetsushi Yoshikawa, S. Suga, I. Kobayashi, T. Nakashima, T. Yazaki, Y. Kajita, T. Ozaki

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Abstract

Objective. To clarify clinical features of patients with primary human herpesvirus 6 (HHV-6) infection (roseola infantum, exanthem subitum) in a large-scale study. Subjects and methods. Clinical signs and symptoms were analyzed in 176 infants in whom exanthem subitum was initially suspected and primary HHV-6 infection was later confirmed. The infection was proved by isolation of the virus from blood, a significant increase in the neutralizing antibody titers to the virus, or both. Results. The primary HHV-6 infection, which occurred throughout the year, was observed in 94 boys and 82 girls (mean age, 7.3 months). Fever developed in 98% (mean maximum fever, 39.4°C) and lasted for 4.1 days. Macular or papular rashes appeared in 98%, on face, trunk, or both, mostly at the time of subsidence of the fever, and lasted for 3.8 days. Other clinical manifestations occurred as follows: mild diarrhea in 68%, edematous eyelids in 30%, erythematous papules in the pharynx in 65%, cough in 50%, and mild cervical lymph node swelling in 31%. Twenty-six percent had bulging of the anterior fontanelle and 8% had convulsions. Conclusions. Clinical features of patients with virologically confirmed exanthem subitum were comparable with those described before discovery of HHV-6.

Original languageEnglish
Pages (from-to)104-108
Number of pages5
JournalPediatrics
Volume93
Issue number1
Publication statusPublished - 01-01-1994

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Exanthema Subitum
Human Herpesvirus 6
Herpesviridae Infections
Exanthema
Fever
Cranial Fontanelles
Eyelids
Pharynx
Neutralizing Antibodies
Viral Load
Cough
Signs and Symptoms
Diarrhea
Seizures
Lymph Nodes
Viruses
Infection

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Cite this

Asano, Y., Yoshikawa, T., Suga, S., Kobayashi, I., Nakashima, T., Yazaki, T., ... Ozaki, T. (1994). Clinical features of infants with primary human herpesvirus 6 infection (exanthem subitum, roseola infantum). Pediatrics, 93(1), 104-108.
Asano, Y. ; Yoshikawa, Tetsushi ; Suga, S. ; Kobayashi, I. ; Nakashima, T. ; Yazaki, T. ; Kajita, Y. ; Ozaki, T. / Clinical features of infants with primary human herpesvirus 6 infection (exanthem subitum, roseola infantum). In: Pediatrics. 1994 ; Vol. 93, No. 1. pp. 104-108.
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abstract = "Objective. To clarify clinical features of patients with primary human herpesvirus 6 (HHV-6) infection (roseola infantum, exanthem subitum) in a large-scale study. Subjects and methods. Clinical signs and symptoms were analyzed in 176 infants in whom exanthem subitum was initially suspected and primary HHV-6 infection was later confirmed. The infection was proved by isolation of the virus from blood, a significant increase in the neutralizing antibody titers to the virus, or both. Results. The primary HHV-6 infection, which occurred throughout the year, was observed in 94 boys and 82 girls (mean age, 7.3 months). Fever developed in 98{\%} (mean maximum fever, 39.4°C) and lasted for 4.1 days. Macular or papular rashes appeared in 98{\%}, on face, trunk, or both, mostly at the time of subsidence of the fever, and lasted for 3.8 days. Other clinical manifestations occurred as follows: mild diarrhea in 68{\%}, edematous eyelids in 30{\%}, erythematous papules in the pharynx in 65{\%}, cough in 50{\%}, and mild cervical lymph node swelling in 31{\%}. Twenty-six percent had bulging of the anterior fontanelle and 8{\%} had convulsions. Conclusions. Clinical features of patients with virologically confirmed exanthem subitum were comparable with those described before discovery of HHV-6.",
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Asano, Y, Yoshikawa, T, Suga, S, Kobayashi, I, Nakashima, T, Yazaki, T, Kajita, Y & Ozaki, T 1994, 'Clinical features of infants with primary human herpesvirus 6 infection (exanthem subitum, roseola infantum)', Pediatrics, vol. 93, no. 1, pp. 104-108.

Clinical features of infants with primary human herpesvirus 6 infection (exanthem subitum, roseola infantum). / Asano, Y.; Yoshikawa, Tetsushi; Suga, S.; Kobayashi, I.; Nakashima, T.; Yazaki, T.; Kajita, Y.; Ozaki, T.

In: Pediatrics, Vol. 93, No. 1, 01.01.1994, p. 104-108.

Research output: Contribution to journalArticle

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T1 - Clinical features of infants with primary human herpesvirus 6 infection (exanthem subitum, roseola infantum)

AU - Asano, Y.

AU - Yoshikawa, Tetsushi

AU - Suga, S.

AU - Kobayashi, I.

AU - Nakashima, T.

AU - Yazaki, T.

AU - Kajita, Y.

AU - Ozaki, T.

PY - 1994/1/1

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N2 - Objective. To clarify clinical features of patients with primary human herpesvirus 6 (HHV-6) infection (roseola infantum, exanthem subitum) in a large-scale study. Subjects and methods. Clinical signs and symptoms were analyzed in 176 infants in whom exanthem subitum was initially suspected and primary HHV-6 infection was later confirmed. The infection was proved by isolation of the virus from blood, a significant increase in the neutralizing antibody titers to the virus, or both. Results. The primary HHV-6 infection, which occurred throughout the year, was observed in 94 boys and 82 girls (mean age, 7.3 months). Fever developed in 98% (mean maximum fever, 39.4°C) and lasted for 4.1 days. Macular or papular rashes appeared in 98%, on face, trunk, or both, mostly at the time of subsidence of the fever, and lasted for 3.8 days. Other clinical manifestations occurred as follows: mild diarrhea in 68%, edematous eyelids in 30%, erythematous papules in the pharynx in 65%, cough in 50%, and mild cervical lymph node swelling in 31%. Twenty-six percent had bulging of the anterior fontanelle and 8% had convulsions. Conclusions. Clinical features of patients with virologically confirmed exanthem subitum were comparable with those described before discovery of HHV-6.

AB - Objective. To clarify clinical features of patients with primary human herpesvirus 6 (HHV-6) infection (roseola infantum, exanthem subitum) in a large-scale study. Subjects and methods. Clinical signs and symptoms were analyzed in 176 infants in whom exanthem subitum was initially suspected and primary HHV-6 infection was later confirmed. The infection was proved by isolation of the virus from blood, a significant increase in the neutralizing antibody titers to the virus, or both. Results. The primary HHV-6 infection, which occurred throughout the year, was observed in 94 boys and 82 girls (mean age, 7.3 months). Fever developed in 98% (mean maximum fever, 39.4°C) and lasted for 4.1 days. Macular or papular rashes appeared in 98%, on face, trunk, or both, mostly at the time of subsidence of the fever, and lasted for 3.8 days. Other clinical manifestations occurred as follows: mild diarrhea in 68%, edematous eyelids in 30%, erythematous papules in the pharynx in 65%, cough in 50%, and mild cervical lymph node swelling in 31%. Twenty-six percent had bulging of the anterior fontanelle and 8% had convulsions. Conclusions. Clinical features of patients with virologically confirmed exanthem subitum were comparable with those described before discovery of HHV-6.

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Asano Y, Yoshikawa T, Suga S, Kobayashi I, Nakashima T, Yazaki T et al. Clinical features of infants with primary human herpesvirus 6 infection (exanthem subitum, roseola infantum). Pediatrics. 1994 Jan 1;93(1):104-108.