Abstract
Human herpesvirus-6 (HHV-6), a T-lymphotropic herpesvirus, belongs to one of two variants, A or B (HHV-6A and HHV-6B). HHV-6B is the cause of exanthem subitum (ES) which had a wide spectrum of related illnesses in the central nervous system, gastrointestinal tract, respiratory tract, and blood cells including fatal outcome, however, a clear etiologic role has not been identified for HHV-6A. HHV-6 is ubiquitous and primary infection with the virus almost always occurs before the age of 2 years. On the other hand, human herpesvirus-7 (HHV-7), isolated from CD4+ T lymphocytes from the peripheral blood of a healthy individual has been recognized as a new lymphotropic herpesvirus. The virus was distinct from the six previously identified human herpesviruses and had limited homology to human cytomegalovirus and HHV-6 by both molecular and immunological analyses. Healthy adults frequently shed the virus into saliva, and children are infected at a young age but somewhat later than HHV-6B. The primary infection with HHV-7 is linked to febrile illness with or without rash that resembles ES. A consensus is needed on whether the term should be used only for clinical features by primary infection with HHV-6 or for clinical syndromes featuring febrile exanthem by various infectious agents including HHV-6, HHV-7, enteroviruses, etc.
| Original language | English |
|---|---|
| Pages (from-to) | 203-207 |
| Number of pages | 5 |
| Journal | Nippon rinsho. Japanese journal of clinical medicine |
| Volume | 56 |
| Issue number | 1 |
| Publication status | Published - 01-01-1998 |
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All Science Journal Classification (ASJC) codes
- Medicine(all)
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Clinical features of primary HHV-6 and HHV-7 infections. / Suga, S.; Suzuki, K.; Ihira, Masaru; Furukawa, H.; Yoshikawa, Tetsushi; Asano, Y.
In: Nippon rinsho. Japanese journal of clinical medicine, Vol. 56, No. 1, 01.01.1998, p. 203-207.Research output: Contribution to journal › Review article
TY - JOUR
T1 - Clinical features of primary HHV-6 and HHV-7 infections
AU - Suga, S.
AU - Suzuki, K.
AU - Ihira, Masaru
AU - Furukawa, H.
AU - Yoshikawa, Tetsushi
AU - Asano, Y.
PY - 1998/1/1
Y1 - 1998/1/1
N2 - Human herpesvirus-6 (HHV-6), a T-lymphotropic herpesvirus, belongs to one of two variants, A or B (HHV-6A and HHV-6B). HHV-6B is the cause of exanthem subitum (ES) which had a wide spectrum of related illnesses in the central nervous system, gastrointestinal tract, respiratory tract, and blood cells including fatal outcome, however, a clear etiologic role has not been identified for HHV-6A. HHV-6 is ubiquitous and primary infection with the virus almost always occurs before the age of 2 years. On the other hand, human herpesvirus-7 (HHV-7), isolated from CD4+ T lymphocytes from the peripheral blood of a healthy individual has been recognized as a new lymphotropic herpesvirus. The virus was distinct from the six previously identified human herpesviruses and had limited homology to human cytomegalovirus and HHV-6 by both molecular and immunological analyses. Healthy adults frequently shed the virus into saliva, and children are infected at a young age but somewhat later than HHV-6B. The primary infection with HHV-7 is linked to febrile illness with or without rash that resembles ES. A consensus is needed on whether the term should be used only for clinical features by primary infection with HHV-6 or for clinical syndromes featuring febrile exanthem by various infectious agents including HHV-6, HHV-7, enteroviruses, etc.
AB - Human herpesvirus-6 (HHV-6), a T-lymphotropic herpesvirus, belongs to one of two variants, A or B (HHV-6A and HHV-6B). HHV-6B is the cause of exanthem subitum (ES) which had a wide spectrum of related illnesses in the central nervous system, gastrointestinal tract, respiratory tract, and blood cells including fatal outcome, however, a clear etiologic role has not been identified for HHV-6A. HHV-6 is ubiquitous and primary infection with the virus almost always occurs before the age of 2 years. On the other hand, human herpesvirus-7 (HHV-7), isolated from CD4+ T lymphocytes from the peripheral blood of a healthy individual has been recognized as a new lymphotropic herpesvirus. The virus was distinct from the six previously identified human herpesviruses and had limited homology to human cytomegalovirus and HHV-6 by both molecular and immunological analyses. Healthy adults frequently shed the virus into saliva, and children are infected at a young age but somewhat later than HHV-6B. The primary infection with HHV-7 is linked to febrile illness with or without rash that resembles ES. A consensus is needed on whether the term should be used only for clinical features by primary infection with HHV-6 or for clinical syndromes featuring febrile exanthem by various infectious agents including HHV-6, HHV-7, enteroviruses, etc.
UR - http://www.scopus.com/inward/record.url?scp=0031602250&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031602250&partnerID=8YFLogxK
M3 - Review article
C2 - 9465691
AN - SCOPUS:0031602250
VL - 56
SP - 203
EP - 207
JO - Nippon rinsho. Japanese journal of clinical medicine
JF - Nippon rinsho. Japanese journal of clinical medicine
SN - 0047-1852
IS - 1
ER -