Clinical features of primary human herpesvirus-6 infection in an infant with acute lymphoblastic leukemia

Tetsushi Yoshikawa, I. Kobayashi, Y. Asano, T. Nakashima, T. Yazaki, S. Kojima, A. Yamada

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Purpose: The primary infection with human herpesvirus-6 developed concurrently with diagnosis of acute lymphoblastic leukemia and initiation of intensive chemotherapy for the disease in a 4-month-old girl. Results: Prolonged viremia persisted for 7 days in the presence of neutralizing antibodies, and clinical features such as prolonged febrile and diarrheal period, no appearance of skin rash, and marked bulging fontanelle for 7 days in the absence of the virus DNA in spinal fluid may suggest an atypical clinical course of exanthem subitum and an unusual viral replication in immunocompromised condition.

Original languageEnglish
Pages (from-to)424-426
Number of pages3
JournalAmerican Journal of Pediatric Hematology/Oncology
Volume15
Issue number4
Publication statusPublished - 01-01-1993

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Human Herpesvirus 6
Herpesviridae Infections
Exanthema
Precursor Cell Lymphoblastic Leukemia-Lymphoma
DNA Viruses
Viremia
Neutralizing Antibodies
Fever
Drug Therapy
Infection

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

Cite this

Yoshikawa, Tetsushi ; Kobayashi, I. ; Asano, Y. ; Nakashima, T. ; Yazaki, T. ; Kojima, S. ; Yamada, A. / Clinical features of primary human herpesvirus-6 infection in an infant with acute lymphoblastic leukemia. In: American Journal of Pediatric Hematology/Oncology. 1993 ; Vol. 15, No. 4. pp. 424-426.
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Yoshikawa, T, Kobayashi, I, Asano, Y, Nakashima, T, Yazaki, T, Kojima, S & Yamada, A 1993, 'Clinical features of primary human herpesvirus-6 infection in an infant with acute lymphoblastic leukemia', American Journal of Pediatric Hematology/Oncology, vol. 15, no. 4, pp. 424-426.

Clinical features of primary human herpesvirus-6 infection in an infant with acute lymphoblastic leukemia. / Yoshikawa, Tetsushi; Kobayashi, I.; Asano, Y.; Nakashima, T.; Yazaki, T.; Kojima, S.; Yamada, A.

In: American Journal of Pediatric Hematology/Oncology, Vol. 15, No. 4, 01.01.1993, p. 424-426.

Research output: Contribution to journalArticle

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AU - Yoshikawa, Tetsushi

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AU - Asano, Y.

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AU - Yazaki, T.

AU - Kojima, S.

AU - Yamada, A.

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AB - Purpose: The primary infection with human herpesvirus-6 developed concurrently with diagnosis of acute lymphoblastic leukemia and initiation of intensive chemotherapy for the disease in a 4-month-old girl. Results: Prolonged viremia persisted for 7 days in the presence of neutralizing antibodies, and clinical features such as prolonged febrile and diarrheal period, no appearance of skin rash, and marked bulging fontanelle for 7 days in the absence of the virus DNA in spinal fluid may suggest an atypical clinical course of exanthem subitum and an unusual viral replication in immunocompromised condition.

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