Clinical islet transplantation experience of the University of California Islet Transplant Consortium

F. Charles Brunicardi, Azmi Atiya, Peter Stock, Takashi Kenmochi, Satoshi Une, Pierre Y. Benhamou, Philip C. Watt, Masaaki Miyamato, Yoshi Wantanabe, Yasu Nomura, Robert Kleinman, Seiji Arita, Satoki Ohtsuka, Linda Shevlin, Thomas Rosenthal, Ronald W. Busuttil, Yoko Mullen, Edward Passaro

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Background. The University of California Islet Transplant Consortium was formed to evaluate the feasibility of performing clinical islet transplantation at different transplant centers by using a single centralized islet isolation laboratory. Methods. From July 1992 through February 1995 seven adult islet transplantations were performed, six allografts and one autograft. Once procured, human pancreata were brought to the UCLA-VA Islet Core Laboratory for islet isolation and purification, which were then transported to different centers for transplantation. Patients 1 through 3 received their transplants in Los Angeles, patient 4 received her islet transplant in Torrance, and patients 5 through 7 received their transplants in San Francisco. Results. Although none of these patients achieved insulin independence, four of seven had functioning grafts longer than 6 months as indicated by circulating C-peptide level greater than 0.7 ng/ml. Furthermore, improved glucose control as shown by a decreased insulin requirement was seen in 57% (four of seven patients) of these patients. The ability to isolate islets at a single laboratory and transport them long distances to different centers was shown in patients 4 through 7. Conclusions. Islet transplantation can be performed with improvements in blood glucose control, and islets can be isolated at a centralized location and successfully transported to different centers for transplantation.

Original languageEnglish
Pages (from-to)967-972
Number of pages6
JournalSurgery
Volume118
Issue number6
DOIs
Publication statusPublished - 01-01-1995

Fingerprint

Islets of Langerhans Transplantation
Transplants
Transplantation
Insulin
San Francisco
Los Angeles
C-Peptide
Autografts
Allografts
Blood Glucose
Pancreas
Glucose

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

Brunicardi, F. C., Atiya, A., Stock, P., Kenmochi, T., Une, S., Benhamou, P. Y., ... Passaro, E. (1995). Clinical islet transplantation experience of the University of California Islet Transplant Consortium. Surgery, 118(6), 967-972. https://doi.org/10.1016/S0039-6060(05)80101-1
Brunicardi, F. Charles ; Atiya, Azmi ; Stock, Peter ; Kenmochi, Takashi ; Une, Satoshi ; Benhamou, Pierre Y. ; Watt, Philip C. ; Miyamato, Masaaki ; Wantanabe, Yoshi ; Nomura, Yasu ; Kleinman, Robert ; Arita, Seiji ; Ohtsuka, Satoki ; Shevlin, Linda ; Rosenthal, Thomas ; Busuttil, Ronald W. ; Mullen, Yoko ; Passaro, Edward. / Clinical islet transplantation experience of the University of California Islet Transplant Consortium. In: Surgery. 1995 ; Vol. 118, No. 6. pp. 967-972.
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abstract = "Background. The University of California Islet Transplant Consortium was formed to evaluate the feasibility of performing clinical islet transplantation at different transplant centers by using a single centralized islet isolation laboratory. Methods. From July 1992 through February 1995 seven adult islet transplantations were performed, six allografts and one autograft. Once procured, human pancreata were brought to the UCLA-VA Islet Core Laboratory for islet isolation and purification, which were then transported to different centers for transplantation. Patients 1 through 3 received their transplants in Los Angeles, patient 4 received her islet transplant in Torrance, and patients 5 through 7 received their transplants in San Francisco. Results. Although none of these patients achieved insulin independence, four of seven had functioning grafts longer than 6 months as indicated by circulating C-peptide level greater than 0.7 ng/ml. Furthermore, improved glucose control as shown by a decreased insulin requirement was seen in 57{\%} (four of seven patients) of these patients. The ability to isolate islets at a single laboratory and transport them long distances to different centers was shown in patients 4 through 7. Conclusions. Islet transplantation can be performed with improvements in blood glucose control, and islets can be isolated at a centralized location and successfully transported to different centers for transplantation.",
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Brunicardi, FC, Atiya, A, Stock, P, Kenmochi, T, Une, S, Benhamou, PY, Watt, PC, Miyamato, M, Wantanabe, Y, Nomura, Y, Kleinman, R, Arita, S, Ohtsuka, S, Shevlin, L, Rosenthal, T, Busuttil, RW, Mullen, Y & Passaro, E 1995, 'Clinical islet transplantation experience of the University of California Islet Transplant Consortium', Surgery, vol. 118, no. 6, pp. 967-972. https://doi.org/10.1016/S0039-6060(05)80101-1

Clinical islet transplantation experience of the University of California Islet Transplant Consortium. / Brunicardi, F. Charles; Atiya, Azmi; Stock, Peter; Kenmochi, Takashi; Une, Satoshi; Benhamou, Pierre Y.; Watt, Philip C.; Miyamato, Masaaki; Wantanabe, Yoshi; Nomura, Yasu; Kleinman, Robert; Arita, Seiji; Ohtsuka, Satoki; Shevlin, Linda; Rosenthal, Thomas; Busuttil, Ronald W.; Mullen, Yoko; Passaro, Edward.

In: Surgery, Vol. 118, No. 6, 01.01.1995, p. 967-972.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Clinical islet transplantation experience of the University of California Islet Transplant Consortium

AU - Brunicardi, F. Charles

AU - Atiya, Azmi

AU - Stock, Peter

AU - Kenmochi, Takashi

AU - Une, Satoshi

AU - Benhamou, Pierre Y.

AU - Watt, Philip C.

AU - Miyamato, Masaaki

AU - Wantanabe, Yoshi

AU - Nomura, Yasu

AU - Kleinman, Robert

AU - Arita, Seiji

AU - Ohtsuka, Satoki

AU - Shevlin, Linda

AU - Rosenthal, Thomas

AU - Busuttil, Ronald W.

AU - Mullen, Yoko

AU - Passaro, Edward

PY - 1995/1/1

Y1 - 1995/1/1

N2 - Background. The University of California Islet Transplant Consortium was formed to evaluate the feasibility of performing clinical islet transplantation at different transplant centers by using a single centralized islet isolation laboratory. Methods. From July 1992 through February 1995 seven adult islet transplantations were performed, six allografts and one autograft. Once procured, human pancreata were brought to the UCLA-VA Islet Core Laboratory for islet isolation and purification, which were then transported to different centers for transplantation. Patients 1 through 3 received their transplants in Los Angeles, patient 4 received her islet transplant in Torrance, and patients 5 through 7 received their transplants in San Francisco. Results. Although none of these patients achieved insulin independence, four of seven had functioning grafts longer than 6 months as indicated by circulating C-peptide level greater than 0.7 ng/ml. Furthermore, improved glucose control as shown by a decreased insulin requirement was seen in 57% (four of seven patients) of these patients. The ability to isolate islets at a single laboratory and transport them long distances to different centers was shown in patients 4 through 7. Conclusions. Islet transplantation can be performed with improvements in blood glucose control, and islets can be isolated at a centralized location and successfully transported to different centers for transplantation.

AB - Background. The University of California Islet Transplant Consortium was formed to evaluate the feasibility of performing clinical islet transplantation at different transplant centers by using a single centralized islet isolation laboratory. Methods. From July 1992 through February 1995 seven adult islet transplantations were performed, six allografts and one autograft. Once procured, human pancreata were brought to the UCLA-VA Islet Core Laboratory for islet isolation and purification, which were then transported to different centers for transplantation. Patients 1 through 3 received their transplants in Los Angeles, patient 4 received her islet transplant in Torrance, and patients 5 through 7 received their transplants in San Francisco. Results. Although none of these patients achieved insulin independence, four of seven had functioning grafts longer than 6 months as indicated by circulating C-peptide level greater than 0.7 ng/ml. Furthermore, improved glucose control as shown by a decreased insulin requirement was seen in 57% (four of seven patients) of these patients. The ability to isolate islets at a single laboratory and transport them long distances to different centers was shown in patients 4 through 7. Conclusions. Islet transplantation can be performed with improvements in blood glucose control, and islets can be isolated at a centralized location and successfully transported to different centers for transplantation.

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