Clinical isolates of Streptococcus mitis/oralis-related species with reduced carbapenem susceptibility, harboring amino acid substitutions in penicillin-binding proteins in Japan

Jayathilake Sarangi; Ayaka Ido; Masaya Ito; Chihiro Iinuma; Yo Doyama; Wanchun Jin; Jun Ichi Wachino; Masahiro Suzuki; Mitsutaka Iguchi; Tetsuya Yagi; Yoshichika Arakawa; Kouji Kimura

doi:10.1128/aac.01179-23

Clinical isolates of Streptococcus mitis/oralis-related species with reduced carbapenem susceptibility, harboring amino acid substitutions in penicillin-binding proteins in Japan

Jayathilake Sarangi, Ayaka Ido, Masaya Ito, Chihiro Iinuma, Yo Doyama, Wanchun Jin, Jun Ichi Wachino, Masahiro Suzuki, Mitsutaka Iguchi, Tetsuya Yagi, Yoshichika Arakawa, Kouji Kimura

Microbiology

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Streptococcus mitis/oralis group isolates with reduced carbapenem susceptibility have been reported, but its isolation rate in Japan is unknown. We collected 356 clinical α-hemolytic streptococcal isolates and identified 142 of them as S. mitis/oralis using partial sodA sequencing. The rate of meropenem non-susceptibility was 17.6% (25/142). All 25 carbapenem-non-susceptible isolates harbored amino acid substitutions in/near the conserved motifs in PBP1A, PBP2B, and PBP2X. Carbapenem non-susceptibility is common among S. mitis/oralis group isolates in Japan.

Original language	English
Journal	Antimicrobial agents and chemotherapy
Volume	68
Issue number	4
DOIs	https://doi.org/10.1128/aac.01179-23
Publication status	Published - 04-2024

All Science Journal Classification (ASJC) codes

Pharmacology
Pharmacology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1128/aac.01179-23

Cite this

Sarangi, J., Ido, A., Ito, M., Iinuma, C., Doyama, Y., Jin, W., Wachino, J. I., Suzuki, M., Iguchi, M., Yagi, T., Arakawa, Y., & Kimura, K. (2024). Clinical isolates of Streptococcus mitis/oralis-related species with reduced carbapenem susceptibility, harboring amino acid substitutions in penicillin-binding proteins in Japan. Antimicrobial agents and chemotherapy, 68(4). https://doi.org/10.1128/aac.01179-23

@article{2613a0e673594d2eadbd09e4aac4f959,

title = "Clinical isolates of Streptococcus mitis/oralis-related species with reduced carbapenem susceptibility, harboring amino acid substitutions in penicillin-binding proteins in Japan",

abstract = "Streptococcus mitis/oralis group isolates with reduced carbapenem susceptibility have been reported, but its isolation rate in Japan is unknown. We collected 356 clinical α-hemolytic streptococcal isolates and identified 142 of them as S. mitis/oralis using partial sodA sequencing. The rate of meropenem non-susceptibility was 17.6% (25/142). All 25 carbapenem-non-susceptible isolates harbored amino acid substitutions in/near the conserved motifs in PBP1A, PBP2B, and PBP2X. Carbapenem non-susceptibility is common among S. mitis/oralis group isolates in Japan.",

keywords = "Streptococcus mitis/oralis, penicillin-binding protein, reduced carbapenem susceptibility",

author = "Jayathilake Sarangi and Ayaka Ido and Masaya Ito and Chihiro Iinuma and Yo Doyama and Wanchun Jin and Wachino, {Jun Ichi} and Masahiro Suzuki and Mitsutaka Iguchi and Tetsuya Yagi and Yoshichika Arakawa and Kouji Kimura",

year = "2024",

month = apr,

doi = "10.1128/aac.01179-23",

language = "English",

volume = "68",

journal = "Antimicrobial agents and chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

number = "4",

}

Sarangi, J, Ido, A, Ito, M, Iinuma, C, Doyama, Y, Jin, W, Wachino, JI , Suzuki, M, Iguchi, M, Yagi, T, Arakawa, Y & Kimura, K 2024, 'Clinical isolates of Streptococcus mitis/oralis-related species with reduced carbapenem susceptibility, harboring amino acid substitutions in penicillin-binding proteins in Japan', Antimicrobial agents and chemotherapy, vol. 68, no. 4. https://doi.org/10.1128/aac.01179-23

Clinical isolates of Streptococcus mitis/oralis-related species with reduced carbapenem susceptibility, harboring amino acid substitutions in penicillin-binding proteins in Japan. / Sarangi, Jayathilake; Ido, Ayaka; Ito, Masaya et al.
In: Antimicrobial agents and chemotherapy, Vol. 68, No. 4, 04.2024.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Clinical isolates of Streptococcus mitis/oralis-related species with reduced carbapenem susceptibility, harboring amino acid substitutions in penicillin-binding proteins in Japan

AU - Sarangi, Jayathilake

AU - Ido, Ayaka

AU - Ito, Masaya

AU - Iinuma, Chihiro

AU - Doyama, Yo

AU - Jin, Wanchun

AU - Wachino, Jun Ichi

AU - Suzuki, Masahiro

AU - Iguchi, Mitsutaka

AU - Yagi, Tetsuya

AU - Arakawa, Yoshichika

AU - Kimura, Kouji

PY - 2024/4

Y1 - 2024/4

N2 - Streptococcus mitis/oralis group isolates with reduced carbapenem susceptibility have been reported, but its isolation rate in Japan is unknown. We collected 356 clinical α-hemolytic streptococcal isolates and identified 142 of them as S. mitis/oralis using partial sodA sequencing. The rate of meropenem non-susceptibility was 17.6% (25/142). All 25 carbapenem-non-susceptible isolates harbored amino acid substitutions in/near the conserved motifs in PBP1A, PBP2B, and PBP2X. Carbapenem non-susceptibility is common among S. mitis/oralis group isolates in Japan.

AB - Streptococcus mitis/oralis group isolates with reduced carbapenem susceptibility have been reported, but its isolation rate in Japan is unknown. We collected 356 clinical α-hemolytic streptococcal isolates and identified 142 of them as S. mitis/oralis using partial sodA sequencing. The rate of meropenem non-susceptibility was 17.6% (25/142). All 25 carbapenem-non-susceptible isolates harbored amino acid substitutions in/near the conserved motifs in PBP1A, PBP2B, and PBP2X. Carbapenem non-susceptibility is common among S. mitis/oralis group isolates in Japan.

KW - Streptococcus mitis/oralis

KW - penicillin-binding protein

KW - reduced carbapenem susceptibility

UR - http://www.scopus.com/inward/record.url?scp=85189798661&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85189798661&partnerID=8YFLogxK

U2 - 10.1128/aac.01179-23

DO - 10.1128/aac.01179-23

M3 - Article

C2 - 38415648

AN - SCOPUS:85189798661

SN - 0066-4804

VL - 68

JO - Antimicrobial agents and chemotherapy

JF - Antimicrobial agents and chemotherapy

IS - 4

ER -

Clinical isolates of Streptococcus mitis/oralis-related species with reduced carbapenem susceptibility, harboring amino acid substitutions in penicillin-binding proteins in Japan

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this