Clinical isolates of Streptococcus mitis/oralis-related species with reduced carbapenem susceptibility, harboring amino acid substitutions in penicillin-binding proteins in Japan

Jayathilake Sarangi; Ayaka Ido; Masaya Ito; Chihiro Iinuma; Yo Doyama; Wanchun Jin; Jun Ichi Wachino; Masahiro Suzuki; Mitsutaka Iguchi; Tetsuya Yagi; Yoshichika Arakawa; Kouji Kimura

doi:10.1128/aac.01179-23

Clinical isolates of Streptococcus mitis/oralis-related species with reduced carbapenem susceptibility, harboring amino acid substitutions in penicillin-binding proteins in Japan

Jayathilake Sarangi
, Ayaka Ido
, Masaya Ito
, Chihiro Iinuma
, Yo Doyama
, Wanchun Jin
, Jun Ichi Wachino
, Masahiro Suzuki
, Mitsutaka Iguchi
, Tetsuya Yagi
, Yoshichika Arakawa
, Kouji Kimura

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Streptococcus mitis/oralis group isolates with reduced carbapenem susceptibility have been reported, but its isolation rate in Japan is unknown. We collected 356 clinical α-hemolytic streptococcal isolates and identified 142 of them as S. mitis/oralis using partial sodA sequencing. The rate of meropenem non-susceptibility was 17.6% (25/142). All 25 carbapenem-non-susceptible isolates harbored amino acid substitutions in/near the conserved motifs in PBP1A, PBP2B, and PBP2X. Carbapenem non-susceptibility is common among S. mitis/oralis group isolates in Japan.

Original language	English
Journal	Antimicrobial agents and chemotherapy
Volume	68
Issue number	4
DOIs	https://doi.org/10.1128/aac.01179-23
Publication status	Published - 04-2024
Externally published	Yes

All Science Journal Classification (ASJC) codes

Pharmacology
Pharmacology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1128/aac.01179-23

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Sarangi, J., Ido, A., Ito, M., Iinuma, C., Doyama, Y., Jin, W., Wachino, J. I., Suzuki, M., Iguchi, M., Yagi, T., Arakawa, Y., & Kimura, K. (2024). Clinical isolates of Streptococcus mitis/oralis-related species with reduced carbapenem susceptibility, harboring amino acid substitutions in penicillin-binding proteins in Japan. Antimicrobial agents and chemotherapy, 68(4). https://doi.org/10.1128/aac.01179-23

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title = "Clinical isolates of Streptococcus mitis/oralis-related species with reduced carbapenem susceptibility, harboring amino acid substitutions in penicillin-binding proteins in Japan",

abstract = "Streptococcus mitis/oralis group isolates with reduced carbapenem susceptibility have been reported, but its isolation rate in Japan is unknown. We collected 356 clinical α-hemolytic streptococcal isolates and identified 142 of them as S. mitis/oralis using partial sodA sequencing. The rate of meropenem non-susceptibility was 17.6\% (25/142). All 25 carbapenem-non-susceptible isolates harbored amino acid substitutions in/near the conserved motifs in PBP1A, PBP2B, and PBP2X. Carbapenem non-susceptibility is common among S. mitis/oralis group isolates in Japan.",

keywords = "Streptococcus mitis/oralis, penicillin-binding protein, reduced carbapenem susceptibility",

author = "Jayathilake Sarangi and Ayaka Ido and Masaya Ito and Chihiro Iinuma and Yo Doyama and Wanchun Jin and Wachino, \{Jun Ichi\} and Masahiro Suzuki and Mitsutaka Iguchi and Tetsuya Yagi and Yoshichika Arakawa and Kouji Kimura",

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month = apr,

doi = "10.1128/aac.01179-23",

language = "English",

volume = "68",

journal = "Antimicrobial agents and chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

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Sarangi, J, Ido, A, Ito, M, Iinuma, C, Doyama, Y, Jin, W, Wachino, JI , Suzuki, M, Iguchi, M, Yagi, T, Arakawa, Y & Kimura, K 2024, 'Clinical isolates of Streptococcus mitis/oralis-related species with reduced carbapenem susceptibility, harboring amino acid substitutions in penicillin-binding proteins in Japan', Antimicrobial agents and chemotherapy, vol. 68, no. 4. https://doi.org/10.1128/aac.01179-23

Clinical isolates of Streptococcus mitis/oralis-related species with reduced carbapenem susceptibility, harboring amino acid substitutions in penicillin-binding proteins in Japan. / Sarangi, Jayathilake; Ido, Ayaka; Ito, Masaya et al.
In: Antimicrobial agents and chemotherapy, Vol. 68, No. 4, 04.2024.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Clinical isolates of Streptococcus mitis/oralis-related species with reduced carbapenem susceptibility, harboring amino acid substitutions in penicillin-binding proteins in Japan

AU - Sarangi, Jayathilake

AU - Ido, Ayaka

AU - Ito, Masaya

AU - Iinuma, Chihiro

AU - Doyama, Yo

AU - Jin, Wanchun

AU - Wachino, Jun Ichi

AU - Suzuki, Masahiro

AU - Iguchi, Mitsutaka

AU - Yagi, Tetsuya

AU - Arakawa, Yoshichika

AU - Kimura, Kouji

PY - 2024/4

Y1 - 2024/4

N2 - Streptococcus mitis/oralis group isolates with reduced carbapenem susceptibility have been reported, but its isolation rate in Japan is unknown. We collected 356 clinical α-hemolytic streptococcal isolates and identified 142 of them as S. mitis/oralis using partial sodA sequencing. The rate of meropenem non-susceptibility was 17.6% (25/142). All 25 carbapenem-non-susceptible isolates harbored amino acid substitutions in/near the conserved motifs in PBP1A, PBP2B, and PBP2X. Carbapenem non-susceptibility is common among S. mitis/oralis group isolates in Japan.

AB - Streptococcus mitis/oralis group isolates with reduced carbapenem susceptibility have been reported, but its isolation rate in Japan is unknown. We collected 356 clinical α-hemolytic streptococcal isolates and identified 142 of them as S. mitis/oralis using partial sodA sequencing. The rate of meropenem non-susceptibility was 17.6% (25/142). All 25 carbapenem-non-susceptible isolates harbored amino acid substitutions in/near the conserved motifs in PBP1A, PBP2B, and PBP2X. Carbapenem non-susceptibility is common among S. mitis/oralis group isolates in Japan.

KW - Streptococcus mitis/oralis

KW - penicillin-binding protein

KW - reduced carbapenem susceptibility

UR - https://www.scopus.com/pages/publications/85189798661

UR - https://www.scopus.com/pages/publications/85189798661#tab=citedBy

U2 - 10.1128/aac.01179-23

DO - 10.1128/aac.01179-23

M3 - Article

C2 - 38415648

AN - SCOPUS:85189798661

SN - 0066-4804

VL - 68

JO - Antimicrobial agents and chemotherapy

JF - Antimicrobial agents and chemotherapy

IS - 4

ER -

Clinical isolates of Streptococcus mitis/oralis-related species with reduced carbapenem susceptibility, harboring amino acid substitutions in penicillin-binding proteins in Japan

Abstract

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