Clinical outcome after bone metastasis (BM) surgery in patients with differentiated thyroid carcinoma (DTC): a retrospective study of 40 cases

Robert Nakayama, Keisuke Horiuchi, Michiro Susa, Itsuo Watanabe, Kota Watanabe, Takashi Tsuji, Morio Matsumoto, Yoshiaki Toyama, Hideo Morioka

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Abstract

OBJECTIVE: The purpose of this study is to identify factors that affect survival of patients with differentiated thyroid carcinoma with bone metastases and to optimize surgical treatment modality for bone metastatic lesion by comparing duration of patient survival and local control.

METHODS: We examined 52 bone metastatic lesions from 40 patients with differentiated thyroid carcinoma who were treated surgically between 1994 and 2008 at Keio University Hospital. Median follow-up time was 46 months (range: 4-233 months). Patients' disease-specific survival, local control duration and factors that potentially affected disease-specific survival after bone metastasis surgery were statistically analyzed.

RESULTS: The 2-, 5- and 10-year disease-specific survival rates were 77.2, 64.3 and 45.7%, respectively. Factors that were significantly associated with poor survival rates in multivariate analyses included age at bone metastasis surgery ≥65 years (P = 0.0068), time from diagnosis of primary cancer to bone metastasis surgery ≥5 years (P = 0.0018) and presence of visceral metastases (P = 0.0092). The 2-, 5- and 10-year local control rates in our series were 91.4, 72.7 and 63.6%, respectively. The 5-year local control rates for radical and palliative surgery were 84.4 and 55.3%, respectively, and differed significantly (P = 0.019).

CONCLUSIONS: Because disease-specific survival of patients with differentiated thyroid carcinoma is fairly good, inadequate treatment of bone metastatic lesions can result in severe disabilities. Therefore, radical surgery for bone metastatic lesions should be considered, especially for those with favorable prognostic factors.

Original languageEnglish
Pages (from-to)918-925
Number of pages8
JournalJapanese journal of clinical oncology
Volume44
Issue number10
DOIs
Publication statusPublished - 01-10-2014

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Thyroid Neoplasms
Retrospective Studies
Neoplasm Metastasis
Bone and Bones
Survival
Survival Rate
Bone Neoplasms
Palliative Care
Multivariate Analysis
Therapeutics

All Science Journal Classification (ASJC) codes

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Cite this

Nakayama, Robert ; Horiuchi, Keisuke ; Susa, Michiro ; Watanabe, Itsuo ; Watanabe, Kota ; Tsuji, Takashi ; Matsumoto, Morio ; Toyama, Yoshiaki ; Morioka, Hideo. / Clinical outcome after bone metastasis (BM) surgery in patients with differentiated thyroid carcinoma (DTC) : a retrospective study of 40 cases. In: Japanese journal of clinical oncology. 2014 ; Vol. 44, No. 10. pp. 918-925.
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abstract = "OBJECTIVE: The purpose of this study is to identify factors that affect survival of patients with differentiated thyroid carcinoma with bone metastases and to optimize surgical treatment modality for bone metastatic lesion by comparing duration of patient survival and local control.METHODS: We examined 52 bone metastatic lesions from 40 patients with differentiated thyroid carcinoma who were treated surgically between 1994 and 2008 at Keio University Hospital. Median follow-up time was 46 months (range: 4-233 months). Patients' disease-specific survival, local control duration and factors that potentially affected disease-specific survival after bone metastasis surgery were statistically analyzed.RESULTS: The 2-, 5- and 10-year disease-specific survival rates were 77.2, 64.3 and 45.7{\%}, respectively. Factors that were significantly associated with poor survival rates in multivariate analyses included age at bone metastasis surgery ≥65 years (P = 0.0068), time from diagnosis of primary cancer to bone metastasis surgery ≥5 years (P = 0.0018) and presence of visceral metastases (P = 0.0092). The 2-, 5- and 10-year local control rates in our series were 91.4, 72.7 and 63.6{\%}, respectively. The 5-year local control rates for radical and palliative surgery were 84.4 and 55.3{\%}, respectively, and differed significantly (P = 0.019).CONCLUSIONS: Because disease-specific survival of patients with differentiated thyroid carcinoma is fairly good, inadequate treatment of bone metastatic lesions can result in severe disabilities. Therefore, radical surgery for bone metastatic lesions should be considered, especially for those with favorable prognostic factors.",
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Clinical outcome after bone metastasis (BM) surgery in patients with differentiated thyroid carcinoma (DTC) : a retrospective study of 40 cases. / Nakayama, Robert; Horiuchi, Keisuke; Susa, Michiro; Watanabe, Itsuo; Watanabe, Kota; Tsuji, Takashi; Matsumoto, Morio; Toyama, Yoshiaki; Morioka, Hideo.

In: Japanese journal of clinical oncology, Vol. 44, No. 10, 01.10.2014, p. 918-925.

Research output: Contribution to journalArticle

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T1 - Clinical outcome after bone metastasis (BM) surgery in patients with differentiated thyroid carcinoma (DTC)

T2 - a retrospective study of 40 cases

AU - Nakayama, Robert

AU - Horiuchi, Keisuke

AU - Susa, Michiro

AU - Watanabe, Itsuo

AU - Watanabe, Kota

AU - Tsuji, Takashi

AU - Matsumoto, Morio

AU - Toyama, Yoshiaki

AU - Morioka, Hideo

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N2 - OBJECTIVE: The purpose of this study is to identify factors that affect survival of patients with differentiated thyroid carcinoma with bone metastases and to optimize surgical treatment modality for bone metastatic lesion by comparing duration of patient survival and local control.METHODS: We examined 52 bone metastatic lesions from 40 patients with differentiated thyroid carcinoma who were treated surgically between 1994 and 2008 at Keio University Hospital. Median follow-up time was 46 months (range: 4-233 months). Patients' disease-specific survival, local control duration and factors that potentially affected disease-specific survival after bone metastasis surgery were statistically analyzed.RESULTS: The 2-, 5- and 10-year disease-specific survival rates were 77.2, 64.3 and 45.7%, respectively. Factors that were significantly associated with poor survival rates in multivariate analyses included age at bone metastasis surgery ≥65 years (P = 0.0068), time from diagnosis of primary cancer to bone metastasis surgery ≥5 years (P = 0.0018) and presence of visceral metastases (P = 0.0092). The 2-, 5- and 10-year local control rates in our series were 91.4, 72.7 and 63.6%, respectively. The 5-year local control rates for radical and palliative surgery were 84.4 and 55.3%, respectively, and differed significantly (P = 0.019).CONCLUSIONS: Because disease-specific survival of patients with differentiated thyroid carcinoma is fairly good, inadequate treatment of bone metastatic lesions can result in severe disabilities. Therefore, radical surgery for bone metastatic lesions should be considered, especially for those with favorable prognostic factors.

AB - OBJECTIVE: The purpose of this study is to identify factors that affect survival of patients with differentiated thyroid carcinoma with bone metastases and to optimize surgical treatment modality for bone metastatic lesion by comparing duration of patient survival and local control.METHODS: We examined 52 bone metastatic lesions from 40 patients with differentiated thyroid carcinoma who were treated surgically between 1994 and 2008 at Keio University Hospital. Median follow-up time was 46 months (range: 4-233 months). Patients' disease-specific survival, local control duration and factors that potentially affected disease-specific survival after bone metastasis surgery were statistically analyzed.RESULTS: The 2-, 5- and 10-year disease-specific survival rates were 77.2, 64.3 and 45.7%, respectively. Factors that were significantly associated with poor survival rates in multivariate analyses included age at bone metastasis surgery ≥65 years (P = 0.0068), time from diagnosis of primary cancer to bone metastasis surgery ≥5 years (P = 0.0018) and presence of visceral metastases (P = 0.0092). The 2-, 5- and 10-year local control rates in our series were 91.4, 72.7 and 63.6%, respectively. The 5-year local control rates for radical and palliative surgery were 84.4 and 55.3%, respectively, and differed significantly (P = 0.019).CONCLUSIONS: Because disease-specific survival of patients with differentiated thyroid carcinoma is fairly good, inadequate treatment of bone metastatic lesions can result in severe disabilities. Therefore, radical surgery for bone metastatic lesions should be considered, especially for those with favorable prognostic factors.

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