Clinical outcomes of hospital-acquired infection with Acinetobacter nosocomialis and Acinetobacter pittii

Sarunyou Chusri, Virasakdi Chongsuvivatwong, Jesabel I. Rivera, Kachornsakdi Silpapojakul, Kamonnut Singkhamanan, Edward McNeil, Yohei Doi

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

The role of Acinetobacter nosocomialis and Acinetobacter pittii, which belong to the A. calcoaceticus-A. baumannii complex, in hospital-acquired infections is increasingly recognized. Here we describe a retrospective cohort study of hospital-acquired A. calcoaceticus-A. baumannii complex infections at a university hospital in Thailand. A total of 222 unique cases were identified between January 2010 and December 2011. The genomospecies of the A. calcoaceticus-A. baumannii complex isolates were classified as follows: A. baumannii, 197 (89%); A. nosocomialis, 18 (8%); and A. pittii, 7 (3%). All A. nosocomialis and A. pittii isolates were susceptible to imipenem and meropenem. The patients infected with A. nosocomialis and A. pittii had lower 30-day mortality than those infected with carbapenem-susceptible A. baumannii (P = 0.025) and carbapenem-resistant A. baumannii (P = 0.013). The factors influencing 30-day mortality were infection with non-baumannii A. calcoaceticus-A. baumannii complex (hazard ratio [HR], 0.12; 95% confidence interval [CI], 0.03 to 0.51; P = 0.004), infection with carbapenem-resistant A. baumannii (HR, 1.57; 95% CI, 0.89 to 2.79; P = 0.105), appropriate empirical antimicrobial therapy (HR, 0.38; 95% CI, 0.23 to 0.61; P < 0.001), and higher acute physiology and chronic health evaluation II (APACHE II) score (HR, 1.15; 95% CI, 1.10 to 1.19; P < 0.001). In Galleria mellonella assays, the survival rates were significantly higher for the larvae infected with A. nosocomialis or A. pittii than for those infected with either carbapenem-susceptible A. baumannii or carbapenem-resistant A. baumannii, but no differences in survival rates were observed between carbapenem-susceptible A. baumannii and carbapenem-resistant A. baumannii. These findings suggest intrinsic differences in virulence between non-baumannii A. calcoaceticus-A. baumannii complex species and A. baumannii but not between carbapenem-susceptible and resistant A. baumannii.

Original languageEnglish
Pages (from-to)4172-4179
Number of pages8
JournalAntimicrobial agents and chemotherapy
Volume58
Issue number7
DOIs
Publication statusPublished - 01-01-2014

Fingerprint

Acinetobacter
Carbapenems
Cross Infection
Confidence Intervals
meropenem
Survival Rate
Infection
APACHE
Mortality
Imipenem
Thailand
Larva
Virulence
Cohort Studies
Retrospective Studies

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Chusri, S., Chongsuvivatwong, V., Rivera, J. I., Silpapojakul, K., Singkhamanan, K., McNeil, E., & Doi, Y. (2014). Clinical outcomes of hospital-acquired infection with Acinetobacter nosocomialis and Acinetobacter pittii. Antimicrobial agents and chemotherapy, 58(7), 4172-4179. https://doi.org/10.1128/AAC.02992-14
Chusri, Sarunyou ; Chongsuvivatwong, Virasakdi ; Rivera, Jesabel I. ; Silpapojakul, Kachornsakdi ; Singkhamanan, Kamonnut ; McNeil, Edward ; Doi, Yohei. / Clinical outcomes of hospital-acquired infection with Acinetobacter nosocomialis and Acinetobacter pittii. In: Antimicrobial agents and chemotherapy. 2014 ; Vol. 58, No. 7. pp. 4172-4179.
@article{08cecd27ae394b858ff4c39ada8c6a13,
title = "Clinical outcomes of hospital-acquired infection with Acinetobacter nosocomialis and Acinetobacter pittii",
abstract = "The role of Acinetobacter nosocomialis and Acinetobacter pittii, which belong to the A. calcoaceticus-A. baumannii complex, in hospital-acquired infections is increasingly recognized. Here we describe a retrospective cohort study of hospital-acquired A. calcoaceticus-A. baumannii complex infections at a university hospital in Thailand. A total of 222 unique cases were identified between January 2010 and December 2011. The genomospecies of the A. calcoaceticus-A. baumannii complex isolates were classified as follows: A. baumannii, 197 (89{\%}); A. nosocomialis, 18 (8{\%}); and A. pittii, 7 (3{\%}). All A. nosocomialis and A. pittii isolates were susceptible to imipenem and meropenem. The patients infected with A. nosocomialis and A. pittii had lower 30-day mortality than those infected with carbapenem-susceptible A. baumannii (P = 0.025) and carbapenem-resistant A. baumannii (P = 0.013). The factors influencing 30-day mortality were infection with non-baumannii A. calcoaceticus-A. baumannii complex (hazard ratio [HR], 0.12; 95{\%} confidence interval [CI], 0.03 to 0.51; P = 0.004), infection with carbapenem-resistant A. baumannii (HR, 1.57; 95{\%} CI, 0.89 to 2.79; P = 0.105), appropriate empirical antimicrobial therapy (HR, 0.38; 95{\%} CI, 0.23 to 0.61; P < 0.001), and higher acute physiology and chronic health evaluation II (APACHE II) score (HR, 1.15; 95{\%} CI, 1.10 to 1.19; P < 0.001). In Galleria mellonella assays, the survival rates were significantly higher for the larvae infected with A. nosocomialis or A. pittii than for those infected with either carbapenem-susceptible A. baumannii or carbapenem-resistant A. baumannii, but no differences in survival rates were observed between carbapenem-susceptible A. baumannii and carbapenem-resistant A. baumannii. These findings suggest intrinsic differences in virulence between non-baumannii A. calcoaceticus-A. baumannii complex species and A. baumannii but not between carbapenem-susceptible and resistant A. baumannii.",
author = "Sarunyou Chusri and Virasakdi Chongsuvivatwong and Rivera, {Jesabel I.} and Kachornsakdi Silpapojakul and Kamonnut Singkhamanan and Edward McNeil and Yohei Doi",
year = "2014",
month = "1",
day = "1",
doi = "10.1128/AAC.02992-14",
language = "English",
volume = "58",
pages = "4172--4179",
journal = "Antimicrobial Agents and Chemotherapy",
issn = "0066-4804",
publisher = "American Society for Microbiology",
number = "7",

}

Chusri, S, Chongsuvivatwong, V, Rivera, JI, Silpapojakul, K, Singkhamanan, K, McNeil, E & Doi, Y 2014, 'Clinical outcomes of hospital-acquired infection with Acinetobacter nosocomialis and Acinetobacter pittii', Antimicrobial agents and chemotherapy, vol. 58, no. 7, pp. 4172-4179. https://doi.org/10.1128/AAC.02992-14

Clinical outcomes of hospital-acquired infection with Acinetobacter nosocomialis and Acinetobacter pittii. / Chusri, Sarunyou; Chongsuvivatwong, Virasakdi; Rivera, Jesabel I.; Silpapojakul, Kachornsakdi; Singkhamanan, Kamonnut; McNeil, Edward; Doi, Yohei.

In: Antimicrobial agents and chemotherapy, Vol. 58, No. 7, 01.01.2014, p. 4172-4179.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Clinical outcomes of hospital-acquired infection with Acinetobacter nosocomialis and Acinetobacter pittii

AU - Chusri, Sarunyou

AU - Chongsuvivatwong, Virasakdi

AU - Rivera, Jesabel I.

AU - Silpapojakul, Kachornsakdi

AU - Singkhamanan, Kamonnut

AU - McNeil, Edward

AU - Doi, Yohei

PY - 2014/1/1

Y1 - 2014/1/1

N2 - The role of Acinetobacter nosocomialis and Acinetobacter pittii, which belong to the A. calcoaceticus-A. baumannii complex, in hospital-acquired infections is increasingly recognized. Here we describe a retrospective cohort study of hospital-acquired A. calcoaceticus-A. baumannii complex infections at a university hospital in Thailand. A total of 222 unique cases were identified between January 2010 and December 2011. The genomospecies of the A. calcoaceticus-A. baumannii complex isolates were classified as follows: A. baumannii, 197 (89%); A. nosocomialis, 18 (8%); and A. pittii, 7 (3%). All A. nosocomialis and A. pittii isolates were susceptible to imipenem and meropenem. The patients infected with A. nosocomialis and A. pittii had lower 30-day mortality than those infected with carbapenem-susceptible A. baumannii (P = 0.025) and carbapenem-resistant A. baumannii (P = 0.013). The factors influencing 30-day mortality were infection with non-baumannii A. calcoaceticus-A. baumannii complex (hazard ratio [HR], 0.12; 95% confidence interval [CI], 0.03 to 0.51; P = 0.004), infection with carbapenem-resistant A. baumannii (HR, 1.57; 95% CI, 0.89 to 2.79; P = 0.105), appropriate empirical antimicrobial therapy (HR, 0.38; 95% CI, 0.23 to 0.61; P < 0.001), and higher acute physiology and chronic health evaluation II (APACHE II) score (HR, 1.15; 95% CI, 1.10 to 1.19; P < 0.001). In Galleria mellonella assays, the survival rates were significantly higher for the larvae infected with A. nosocomialis or A. pittii than for those infected with either carbapenem-susceptible A. baumannii or carbapenem-resistant A. baumannii, but no differences in survival rates were observed between carbapenem-susceptible A. baumannii and carbapenem-resistant A. baumannii. These findings suggest intrinsic differences in virulence between non-baumannii A. calcoaceticus-A. baumannii complex species and A. baumannii but not between carbapenem-susceptible and resistant A. baumannii.

AB - The role of Acinetobacter nosocomialis and Acinetobacter pittii, which belong to the A. calcoaceticus-A. baumannii complex, in hospital-acquired infections is increasingly recognized. Here we describe a retrospective cohort study of hospital-acquired A. calcoaceticus-A. baumannii complex infections at a university hospital in Thailand. A total of 222 unique cases were identified between January 2010 and December 2011. The genomospecies of the A. calcoaceticus-A. baumannii complex isolates were classified as follows: A. baumannii, 197 (89%); A. nosocomialis, 18 (8%); and A. pittii, 7 (3%). All A. nosocomialis and A. pittii isolates were susceptible to imipenem and meropenem. The patients infected with A. nosocomialis and A. pittii had lower 30-day mortality than those infected with carbapenem-susceptible A. baumannii (P = 0.025) and carbapenem-resistant A. baumannii (P = 0.013). The factors influencing 30-day mortality were infection with non-baumannii A. calcoaceticus-A. baumannii complex (hazard ratio [HR], 0.12; 95% confidence interval [CI], 0.03 to 0.51; P = 0.004), infection with carbapenem-resistant A. baumannii (HR, 1.57; 95% CI, 0.89 to 2.79; P = 0.105), appropriate empirical antimicrobial therapy (HR, 0.38; 95% CI, 0.23 to 0.61; P < 0.001), and higher acute physiology and chronic health evaluation II (APACHE II) score (HR, 1.15; 95% CI, 1.10 to 1.19; P < 0.001). In Galleria mellonella assays, the survival rates were significantly higher for the larvae infected with A. nosocomialis or A. pittii than for those infected with either carbapenem-susceptible A. baumannii or carbapenem-resistant A. baumannii, but no differences in survival rates were observed between carbapenem-susceptible A. baumannii and carbapenem-resistant A. baumannii. These findings suggest intrinsic differences in virulence between non-baumannii A. calcoaceticus-A. baumannii complex species and A. baumannii but not between carbapenem-susceptible and resistant A. baumannii.

UR - http://www.scopus.com/inward/record.url?scp=84903126411&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84903126411&partnerID=8YFLogxK

U2 - 10.1128/AAC.02992-14

DO - 10.1128/AAC.02992-14

M3 - Article

VL - 58

SP - 4172

EP - 4179

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

SN - 0066-4804

IS - 7

ER -

Chusri S, Chongsuvivatwong V, Rivera JI, Silpapojakul K, Singkhamanan K, McNeil E et al. Clinical outcomes of hospital-acquired infection with Acinetobacter nosocomialis and Acinetobacter pittii. Antimicrobial agents and chemotherapy. 2014 Jan 1;58(7):4172-4179. https://doi.org/10.1128/AAC.02992-14