Clinical-pathological implication of human leukocyte antigen-F-positive gastric adenocarcinoma

Sumiya Ishigami, Takaaki Arigami, Testuro Setoyama, Hiroshi Okumura, Ken Sasaki, Yasuto Uchikado, Hiroshi Kurahara, Yuko Kijima, Yuka Nishizono, Akihiro Nakajo, Shoji Natsugoe

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


Background: Human leukocyte antigen (HLA)-F is a nonclassical HLA class I molecule that shows aberrant expression in cancer cells. Although the clinical implications of HLA-F expression in cancer patients have been described, the specific significance of this antigen in gastrointestinal cancer remains unclear. The present study examined the expression pattern and clinical implications of HLA-F in gastric adenocarcinoma. Patients and methods: HLA-F expression was assessed in 179 patients by immunohistochemistry, and its association with clinical parameters including patient survival was analyzed. Results: HLA-F expression was positive in 30.7% (55/179) of patients and in 50.0% (90/179) of peritumoral infiltrating lymphocytes. HLA-F expression in gastric adenocarcinoma was significantly correlated with the depth of invasion, nodal involvement, and lymphatic and venous invasions (P < 0.01, all). HLA-F positivity of infiltrating cells near the tumor showed no correlation with clinicopathological features. HLA-F-positive patients had a significantly worse prognosis than HLA-F-negative patients (P = 0.012). However, HLA-F expression was not an independent prognostic factor in multivariate analysis. Conclusions: The present study provides the first evidence that neo-HLA-F expression is of clinical significance in gastric adenocarcinoma. HLA-F expression in gastric adenocarcinoma may promote the aggressive behavior of tumors by suppressing the activity of antitumor immune effector cells.

Original languageEnglish
Pages (from-to)802-806
Number of pages5
JournalJournal of Surgical Research
Issue number2
Publication statusPublished - 10-2013
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Surgery


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