Clinical protocol for angiogenesis by intramyocardial injection of autologous bone marrow mononuclear cells in patients with severe coronary artery disease: TACT-NAGOYA-HEART

Hideo Izawa, Takahisa Kondo, Akihiko Usui, Koji Yamamoto, Satoshi Shintani, Yasuya Inden, Satoshi Isobe, Kazumasa Unno, Masahiro Kajiguchi, Tomoko Kato, Akiko Noda, Kenji Okumura, Tomoki Naoe, Junki Takamatsu, Kimihiro Komori, Yuichi Ueda, Toyoaki Murohara

Research output: Contribution to journalArticle

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Abstract

Background: Despite recent improvements in the treatments of coronary artery disease (CAD), there are a considerable number of patients who can not receive complete revascularization because of severe or total arterial occlusion. Intramyocardial injection of autologous bone marrow mononuclear cells (ABMMCs) has been shown to induce neovascularization of ischemic myocardium. Methods and Results: The study will investigate the safety and feasibility of intramyocardial injections of ABMMCs and test the hypothesis that this treatment would promote neovascularization and improve left ventricular (LV) global and/or regional function in patients with severe CAD who have no other option. ABMMCs (∼106 cells) will be injected into the area of ischemic myocardium where the coronary artery is not graftable, in combination with bypass surgery to the other coronary branches. Myocardial perfusion and LV global and regional function will be evaluated, based on the micromanometer-tipped catheter method, single-photon emission tomography, and myocardial enhanced and color tissue Doppler echocardiography at baseline and during 12 month follow-up. Conclusions: This project will demonstrate that intramyocardial injection of ABMMCs with or without coronary artery bypass surgery could be a safe and effective method for therapeutic neovascularization, resulting in an improvement of cardiac function in patients with severe CAD.

Original languageEnglish
Pages (from-to)1180-1183
Number of pages4
JournalCirculation Journal
Volume70
Issue number9
DOIs
Publication statusPublished - 20-09-2006

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Clinical Protocols
Bone Marrow Cells
Coronary Artery Disease
Injections
Myocardium
Doppler Color Echocardiography
Photons
Coronary Artery Bypass
Coronary Vessels
Therapeutics
Catheters
Perfusion
Tomography
Safety
bis(tetraheptylammonium)tetraiodocyclopentane tellurate(IV)

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Izawa, Hideo ; Kondo, Takahisa ; Usui, Akihiko ; Yamamoto, Koji ; Shintani, Satoshi ; Inden, Yasuya ; Isobe, Satoshi ; Unno, Kazumasa ; Kajiguchi, Masahiro ; Kato, Tomoko ; Noda, Akiko ; Okumura, Kenji ; Naoe, Tomoki ; Takamatsu, Junki ; Komori, Kimihiro ; Ueda, Yuichi ; Murohara, Toyoaki. / Clinical protocol for angiogenesis by intramyocardial injection of autologous bone marrow mononuclear cells in patients with severe coronary artery disease : TACT-NAGOYA-HEART. In: Circulation Journal. 2006 ; Vol. 70, No. 9. pp. 1180-1183.
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title = "Clinical protocol for angiogenesis by intramyocardial injection of autologous bone marrow mononuclear cells in patients with severe coronary artery disease: TACT-NAGOYA-HEART",
abstract = "Background: Despite recent improvements in the treatments of coronary artery disease (CAD), there are a considerable number of patients who can not receive complete revascularization because of severe or total arterial occlusion. Intramyocardial injection of autologous bone marrow mononuclear cells (ABMMCs) has been shown to induce neovascularization of ischemic myocardium. Methods and Results: The study will investigate the safety and feasibility of intramyocardial injections of ABMMCs and test the hypothesis that this treatment would promote neovascularization and improve left ventricular (LV) global and/or regional function in patients with severe CAD who have no other option. ABMMCs (∼106 cells) will be injected into the area of ischemic myocardium where the coronary artery is not graftable, in combination with bypass surgery to the other coronary branches. Myocardial perfusion and LV global and regional function will be evaluated, based on the micromanometer-tipped catheter method, single-photon emission tomography, and myocardial enhanced and color tissue Doppler echocardiography at baseline and during 12 month follow-up. Conclusions: This project will demonstrate that intramyocardial injection of ABMMCs with or without coronary artery bypass surgery could be a safe and effective method for therapeutic neovascularization, resulting in an improvement of cardiac function in patients with severe CAD.",
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Izawa, H, Kondo, T, Usui, A, Yamamoto, K, Shintani, S, Inden, Y, Isobe, S, Unno, K, Kajiguchi, M, Kato, T, Noda, A, Okumura, K, Naoe, T, Takamatsu, J, Komori, K, Ueda, Y & Murohara, T 2006, 'Clinical protocol for angiogenesis by intramyocardial injection of autologous bone marrow mononuclear cells in patients with severe coronary artery disease: TACT-NAGOYA-HEART', Circulation Journal, vol. 70, no. 9, pp. 1180-1183. https://doi.org/10.1253/circj.70.1180

Clinical protocol for angiogenesis by intramyocardial injection of autologous bone marrow mononuclear cells in patients with severe coronary artery disease : TACT-NAGOYA-HEART. / Izawa, Hideo; Kondo, Takahisa; Usui, Akihiko; Yamamoto, Koji; Shintani, Satoshi; Inden, Yasuya; Isobe, Satoshi; Unno, Kazumasa; Kajiguchi, Masahiro; Kato, Tomoko; Noda, Akiko; Okumura, Kenji; Naoe, Tomoki; Takamatsu, Junki; Komori, Kimihiro; Ueda, Yuichi; Murohara, Toyoaki.

In: Circulation Journal, Vol. 70, No. 9, 20.09.2006, p. 1180-1183.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Clinical protocol for angiogenesis by intramyocardial injection of autologous bone marrow mononuclear cells in patients with severe coronary artery disease

T2 - TACT-NAGOYA-HEART

AU - Izawa, Hideo

AU - Kondo, Takahisa

AU - Usui, Akihiko

AU - Yamamoto, Koji

AU - Shintani, Satoshi

AU - Inden, Yasuya

AU - Isobe, Satoshi

AU - Unno, Kazumasa

AU - Kajiguchi, Masahiro

AU - Kato, Tomoko

AU - Noda, Akiko

AU - Okumura, Kenji

AU - Naoe, Tomoki

AU - Takamatsu, Junki

AU - Komori, Kimihiro

AU - Ueda, Yuichi

AU - Murohara, Toyoaki

PY - 2006/9/20

Y1 - 2006/9/20

N2 - Background: Despite recent improvements in the treatments of coronary artery disease (CAD), there are a considerable number of patients who can not receive complete revascularization because of severe or total arterial occlusion. Intramyocardial injection of autologous bone marrow mononuclear cells (ABMMCs) has been shown to induce neovascularization of ischemic myocardium. Methods and Results: The study will investigate the safety and feasibility of intramyocardial injections of ABMMCs and test the hypothesis that this treatment would promote neovascularization and improve left ventricular (LV) global and/or regional function in patients with severe CAD who have no other option. ABMMCs (∼106 cells) will be injected into the area of ischemic myocardium where the coronary artery is not graftable, in combination with bypass surgery to the other coronary branches. Myocardial perfusion and LV global and regional function will be evaluated, based on the micromanometer-tipped catheter method, single-photon emission tomography, and myocardial enhanced and color tissue Doppler echocardiography at baseline and during 12 month follow-up. Conclusions: This project will demonstrate that intramyocardial injection of ABMMCs with or without coronary artery bypass surgery could be a safe and effective method for therapeutic neovascularization, resulting in an improvement of cardiac function in patients with severe CAD.

AB - Background: Despite recent improvements in the treatments of coronary artery disease (CAD), there are a considerable number of patients who can not receive complete revascularization because of severe or total arterial occlusion. Intramyocardial injection of autologous bone marrow mononuclear cells (ABMMCs) has been shown to induce neovascularization of ischemic myocardium. Methods and Results: The study will investigate the safety and feasibility of intramyocardial injections of ABMMCs and test the hypothesis that this treatment would promote neovascularization and improve left ventricular (LV) global and/or regional function in patients with severe CAD who have no other option. ABMMCs (∼106 cells) will be injected into the area of ischemic myocardium where the coronary artery is not graftable, in combination with bypass surgery to the other coronary branches. Myocardial perfusion and LV global and regional function will be evaluated, based on the micromanometer-tipped catheter method, single-photon emission tomography, and myocardial enhanced and color tissue Doppler echocardiography at baseline and during 12 month follow-up. Conclusions: This project will demonstrate that intramyocardial injection of ABMMCs with or without coronary artery bypass surgery could be a safe and effective method for therapeutic neovascularization, resulting in an improvement of cardiac function in patients with severe CAD.

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DO - 10.1253/circj.70.1180

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