Clinical safety and utility of pediatric balloon-Assisted enteroscopy: A multicenter prospective study in japan

Shin Ichiro Hagiwara, Takahiro Kudo, Fumihiko Kakuta, Mikihiro Inoue, Koji Yokoyama, Shuichiro Umetsu, Itaru Iwama, Toshifumi Yodoshi, Maiko Tatsuki, Toshiaki Shimizu, Yoshiko Nakayama

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


Objectives:The benefit of balloon-Assisted enteroscopy (BAE) had been recently documented in pediatric patients, but previous reports are based on single institution experiences. We evaluated the feasibility of pediatric BAE in 8 tertiary referral hospitals throughout Japan.Methods:This was a prospective, multi-institutional study. Patients younger than 18 years were enrolled between April 2014 and March 2017 to undergo double-balloon or single-balloon enteroscopy. Data were collected prospectively using a standardized questionnaire.Results:We enrolled 79 pediatric patients (96 procedures, 70 boys, 26 girls; median age 12.7 years, range 1-17 years). Antegrade (oral-route) BAE was performed in 20 procedures (lowest body weight 12.9kg, youngest age 3.7 years), and retrograde (anal-route) BAE in 76 (lowest body weight 10.8kg, youngest age 1.6 years). Severe adverse events were associated with BAE in 2 patients: 1 with hemorrhage due to polypectomy and 1 with pancreatitis after double-balloon endoscopic retrograde cholangioscopy. No intestinal perforation was reported. Procedure duration of oral-route BAE for diagnosis was significantly longer than anal-route for diagnosis (P<0.001). The overall diagnostic yield for rectal bleeding/positive fecal occult blood test and abdominal pain was 48%. Among 40 patients referred for diagnosis who did not undergo capsule endoscopy, diagnoses were confirmed in 17 (42.5%) patients after BAE.Conclusions:This prospective multicenter observational study documents the efficacy of BAE in pediatric patients.

Original languageEnglish
Pages (from-to)306-310
Number of pages5
JournalJournal of Pediatric Gastroenterology and Nutrition
Issue number3
Publication statusPublished - 01-03-2019
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Gastroenterology


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