Clinical significance of an increased red blood cell distribution width in patients with rectal cancer undergoing chemoradiotherapy followed by surgery

Shozo Ide, Yuji Toiyama, Yoshinaga Okugawa, Yusuke Omura, Takahito Kitajima, Hiroyuki Fujikawa, Junichiro Hiro, Masaki Ohi, Masato Kusunoki

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Purpose: The clinical significance of the red blood cell distribution width (RDW) in patients with rectal cancer undergoing preoperative chemoradiotherapy (CRT) followed by surgery has not been fully evaluated. Methods: In this retrospective study, we investigated the association between the RDW and the prognosis in 120 patients with locally advanced rectal cancer (LARC). We also performed a subgroup analysis limited to patients with pathological TNM stage I–II (ypN[−]) LARC. Results: The RDW standard deviation was used to evaluate the RDW. We set 47.1% as the cut-off value of the RDW for the assessment of the prognosis. The RDW exhibited a significant negative relationship with the serum hemoglobin and albumin levels. An elevated RDW was an independent prognostic factor for the overall survival (OS) and disease-free survival (DFS) in patients with LARC. In addition, an elevated RDW predicted a poor OS and DFS in patients with pathological TNM stage I–II (ypN[−]) LARC. Conclusions: The RDW is a promising predictor of a poor survival and recurrence in patients with LARC treated by CRT.

Original languageEnglish
Pages (from-to)551-559
Number of pages9
JournalSurgery Today
Volume50
Issue number6
DOIs
Publication statusPublished - 01-06-2020
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Surgery

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