Clinical significance of c-reactive protein-to- albumin ratio with rectal cancer patient undergoing chemoradiotherapy followed by surgery

Shozo Ide, Yuji Toiyama, Yoshinaga Okugawa, Satoshi Oki, Hiromi Yasuda, Hiroyuki Fujikawa, Shigeyuki Yoshiyama, Junitiro Hiro, Minako Kobayashi, Masaki Ohi, Toshimitsu Araki, Masato Kusunoki

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19 Citations (Scopus)

Abstract

Background/Aim: This study was designed to evaluate the clinical significance of the C-reactive proteinto- albumin ratio (CAR) in patients with rectal cancer undergoing preoperative chemoradiotherapy (CRT) followed by surgery. Patients and Methods: This retrospective study evaluated the correlation between CAR and prognosis in 115 patients with locally advanced rectal cancer. We also carried out subgroup analyses limited to patients with low modified Glasgow prognosis score (mGPS) (score 0) or pathological TNM stage I-II [ypN(-)]. Results: CAR exhibited significant relationships with sex, tumor invasion, recurrence, serum carcinoembryonic antigen, and mGPS. Elevated CAR was an independent prognostic factor for overall survival (OS) and disease-free survival (DFS) among all patients. Elevated CAR also predicted poor OS and DFS in patients with pathological TNM stage I-II [ypN(-)] and low mGPS score. Conclusion: CAR is a promising predictor of survival and recurrence in patients with rectal cancer treated by CRT.

Original languageEnglish
Pages (from-to)5797-5804
Number of pages8
JournalAnticancer research
Volume37
Issue number10
DOIs
Publication statusPublished - 10-2017
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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