TY - JOUR
T1 - Clinical significance of CADM1/TSLC1/IgSF4 expression in adult T-cell leukemia/lymphoma
AU - Nakahata, S.
AU - Saito, Y.
AU - Marutsuka, K.
AU - Hidaka, T.
AU - Maeda, K.
AU - Hatakeyama, K.
AU - Shiraga, T.
AU - Goto, A.
AU - Takamatsu, N.
AU - Asada, Y.
AU - Utsunomiya, A.
AU - Okayama, A.
AU - Kubuki, Y.
AU - Shimoda, K.
AU - Ukai, Y.
AU - Kurosawa, G.
AU - Morishita, K.
N1 - Funding Information:
This work was supported by grants from the National Institutes of Health ( P30AG013846 ; U01NS093334 , U01NS086659-01 ; RF1AG05416 ; K23NS102399 ), the Department of Veterans' Affairs ( I01-CX001038 ). This publication was also supported by a Pilot Grant from the Boston University Alzheimer's Disease Center ( AG013846 ), as well as the National Center for Advancing Translational Sciences, National Institutes of Health, through BU-CTSI Grant Number 1UL1TR001430 . The content is solely the responsibility of the authors. There is no sponsor.
PY - 2012/6
Y1 - 2012/6
N2 - Cell adhesion molecule 1 (CADM1/TSLC1) was recently identified as a novel cell surface marker for adult T-cell leukemia/lymphoma (ATLL). In this study, we developed various antibodies as diagnostic tools to identify CADM1-positive ATLL leukemia cells. In flow cytometric analysis, the percentages of CD4 CADM1 double-positive cells correlated well with both the percentages of CD4 + CD25 + cells and with abnormal lymphocytes in the peripheral blood of patients with various types of ATLL. Moreover, the degree of CD4CD4 + CADM1CD4 + cells over 1% significantly correlated with the copy number of the human T-lymphotropic virus type 1 (HTLV-1) provirus in the peripheral blood of HTLV-1 carriers and ATLL patients. We also identified a soluble form of CADM1 in the peripheral blood of ATLL patients, and the expression levels of this form were correlated with the levels of soluble interleukin 2 receptor alpha. Moreover, lymphomas derived from ATLL were strongly and specifically stained with a CADM1 antibody. Thus, detection of CD4 CADM1 cells in the peripheral blood, measurement of serum levels of soluble CADM1 and immunohistochemical detection of CADM1 in lymphomas would be a useful set of markers for disease progression in ATLL and may aid in both the early diagnosis and measurement of treatment efficacy for ATLL.
AB - Cell adhesion molecule 1 (CADM1/TSLC1) was recently identified as a novel cell surface marker for adult T-cell leukemia/lymphoma (ATLL). In this study, we developed various antibodies as diagnostic tools to identify CADM1-positive ATLL leukemia cells. In flow cytometric analysis, the percentages of CD4 CADM1 double-positive cells correlated well with both the percentages of CD4 + CD25 + cells and with abnormal lymphocytes in the peripheral blood of patients with various types of ATLL. Moreover, the degree of CD4CD4 + CADM1CD4 + cells over 1% significantly correlated with the copy number of the human T-lymphotropic virus type 1 (HTLV-1) provirus in the peripheral blood of HTLV-1 carriers and ATLL patients. We also identified a soluble form of CADM1 in the peripheral blood of ATLL patients, and the expression levels of this form were correlated with the levels of soluble interleukin 2 receptor alpha. Moreover, lymphomas derived from ATLL were strongly and specifically stained with a CADM1 antibody. Thus, detection of CD4 CADM1 cells in the peripheral blood, measurement of serum levels of soluble CADM1 and immunohistochemical detection of CADM1 in lymphomas would be a useful set of markers for disease progression in ATLL and may aid in both the early diagnosis and measurement of treatment efficacy for ATLL.
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U2 - 10.1038/leu.2011.379
DO - 10.1038/leu.2011.379
M3 - Article
C2 - 22289924
AN - SCOPUS:84862001084
SN - 0887-6924
VL - 26
SP - 1238
EP - 1246
JO - Leukemia
JF - Leukemia
IS - 6
ER -
