Clinical significance of circulating tumor cells in peripheral blood from patients with gastric cancer

Yoshikazu Uenosono, Takaaki Arigami, Tsutomu Kozono, Shigehiro Yanagita, Takahiko Hagihara, Naoto Haraguchi, Daisuke Matsushita, Munetsugu Hirata, Hideo Arima, Yawara Funasako, Yuko Kijima, Akihiro Nakajo, Hiroshi Okumura, Sumiya Ishigami, Shuichi Hokita, Shinichi Ueno, Shoji Natsugoe

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Background The authors hypothesized that circulating tumor cells (CTCs) in patients with gastric cancer are associated with prognosis and disease recurrence. In this study, they evaluated CTCs in gastric cancer and clarified the clinical impact of CTCs. Methods In total, 265 consecutive patients with gastric cancer were enrolled. Fourteen patients were excluded from the analysis, including 12 patients who another cancer and 2 patients who refused the treatment. The remaining 251 patients were divided into 2 groups: 148 patients who underwent gastrectomy (the resection group) and 103 patients who did not undergo gastrectomy (the nonresectable group). Peripheral blood samples were collected before gastrectomy or chemotherapy. A proprietary test for capturing, identifying, and counting CTCs in blood was used for the isolation and enumeration of CTCs. Results CTCs were detected in 16 patients (10.8%) from the resection group and in 62 patients (60.2%) from the nonresectable group. The overall survival rate for the entire cohort was significantly lower in patients with CTCs than in those without CTCs (P <.0001). In the resection group, relapse-free and overall survival in patients with CTCs was significantly lower than in patients without CTCs (P <.0001). It was noteworthy that the expression of CTCs was an independent factor for determining the overall survival of patients with gastric cancer in multivariate analysis (P =.024). In the nonresectable group, the overall survival rate was significantly lower in patients with CTCs than in those without CTCs (P =.0044). Conclusions The evaluation of CTCs in peripheral blood may be a useful tool for predicting tumor progression, prognosis, and the effect of chemotherapy in patients with gastric cancer.

Original languageEnglish
Pages (from-to)3984-3991
Number of pages8
JournalCancer
Volume119
Issue number22
DOIs
Publication statusPublished - 15-11-2013

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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