Clinical significance of diffusion tensor tractography as a predictor of functional recovery after laminoplasty in patients with cervical compressive myelopathy

Masaya Nakamura, Kanehiro Fujiyoshi, Osahiko Tsuji, Tsunehiko Konomi, Naobumi Hosogane, Kota Watanabe, Takashi Tsuji, Ken Ishii, Suketaka Momoshima, Yoshiaki Toyama, Kazuhiro Chiba, Morio Matsumoto

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Object. This study was conducted to determine whether postoperative changes in the fractional anisotropy (FA) value and diffusion tensor imaging of the cervical spinal cord can predict functional outcome for patients with cervical compressive myelopathy (CCM). Methods. Twenty patients with CCM were treated by laminoplasty from 2008 to 2009. Both T2-weighted MRI and diffusion tensor imaging were performed before and after surgery. The FA values were analyzed and fiber tracking was performed. The fiber tract (FT) ratio was calculated according to the following formula: (number of fibers at the compressed level)/(number of fibers at the C-2 level) x 100%. The Japanese Orthopaedic Association scoring system for cervical myelopathy was used to determine pre- and postoperative neurological status of the patients, and the Hirabayashi method was used to calculate the recovery rate. Results. There was no significant difference in recovery rates between patients with and those without intramedullary high signal intensity on preoperative T2-weighted images. Substantial differences in FA value among spinal cord, bone, and CSF made it difficult to obtain a precise FA value for the compressed spinal cord. There was a significant correlation between the preoperative FT ratio and the recovery rate (p = 0.0006). A poor outcome (recovery rate < 40%) could be anticipated for CCM patients with preoperative FT ratios below 60%. Conclusions. The preoperative FT ratio correlated significantly with the recovery rates in CCM patients. Preoperative diffusion tensor tractography can be a new prognostic predictor for neurological recovery in CCM patients after laminoplasty.

Original languageEnglish
Pages (from-to)147-152
Number of pages6
JournalJournal of Neurosurgery: Spine
Volume17
Issue number2
DOIs
Publication statusPublished - 01-08-2012
Externally publishedYes

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Spinal Cord Compression
Diffusion Tensor Imaging
Anisotropy
Spinal Cord
Spinal Cord Diseases
Laminoplasty
Bone and Bones

All Science Journal Classification (ASJC) codes

  • Surgery
  • Neurology
  • Clinical Neurology

Cite this

Nakamura, Masaya ; Fujiyoshi, Kanehiro ; Tsuji, Osahiko ; Konomi, Tsunehiko ; Hosogane, Naobumi ; Watanabe, Kota ; Tsuji, Takashi ; Ishii, Ken ; Momoshima, Suketaka ; Toyama, Yoshiaki ; Chiba, Kazuhiro ; Matsumoto, Morio. / Clinical significance of diffusion tensor tractography as a predictor of functional recovery after laminoplasty in patients with cervical compressive myelopathy. In: Journal of Neurosurgery: Spine. 2012 ; Vol. 17, No. 2. pp. 147-152.
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abstract = "Object. This study was conducted to determine whether postoperative changes in the fractional anisotropy (FA) value and diffusion tensor imaging of the cervical spinal cord can predict functional outcome for patients with cervical compressive myelopathy (CCM). Methods. Twenty patients with CCM were treated by laminoplasty from 2008 to 2009. Both T2-weighted MRI and diffusion tensor imaging were performed before and after surgery. The FA values were analyzed and fiber tracking was performed. The fiber tract (FT) ratio was calculated according to the following formula: (number of fibers at the compressed level)/(number of fibers at the C-2 level) x 100{\%}. The Japanese Orthopaedic Association scoring system for cervical myelopathy was used to determine pre- and postoperative neurological status of the patients, and the Hirabayashi method was used to calculate the recovery rate. Results. There was no significant difference in recovery rates between patients with and those without intramedullary high signal intensity on preoperative T2-weighted images. Substantial differences in FA value among spinal cord, bone, and CSF made it difficult to obtain a precise FA value for the compressed spinal cord. There was a significant correlation between the preoperative FT ratio and the recovery rate (p = 0.0006). A poor outcome (recovery rate < 40{\%}) could be anticipated for CCM patients with preoperative FT ratios below 60{\%}. Conclusions. The preoperative FT ratio correlated significantly with the recovery rates in CCM patients. Preoperative diffusion tensor tractography can be a new prognostic predictor for neurological recovery in CCM patients after laminoplasty.",
author = "Masaya Nakamura and Kanehiro Fujiyoshi and Osahiko Tsuji and Tsunehiko Konomi and Naobumi Hosogane and Kota Watanabe and Takashi Tsuji and Ken Ishii and Suketaka Momoshima and Yoshiaki Toyama and Kazuhiro Chiba and Morio Matsumoto",
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Nakamura, M, Fujiyoshi, K, Tsuji, O, Konomi, T, Hosogane, N, Watanabe, K, Tsuji, T, Ishii, K, Momoshima, S, Toyama, Y, Chiba, K & Matsumoto, M 2012, 'Clinical significance of diffusion tensor tractography as a predictor of functional recovery after laminoplasty in patients with cervical compressive myelopathy', Journal of Neurosurgery: Spine, vol. 17, no. 2, pp. 147-152. https://doi.org/10.3171/2012.5.SPINE1196

Clinical significance of diffusion tensor tractography as a predictor of functional recovery after laminoplasty in patients with cervical compressive myelopathy. / Nakamura, Masaya; Fujiyoshi, Kanehiro; Tsuji, Osahiko; Konomi, Tsunehiko; Hosogane, Naobumi; Watanabe, Kota; Tsuji, Takashi; Ishii, Ken; Momoshima, Suketaka; Toyama, Yoshiaki; Chiba, Kazuhiro; Matsumoto, Morio.

In: Journal of Neurosurgery: Spine, Vol. 17, No. 2, 01.08.2012, p. 147-152.

Research output: Contribution to journalArticle

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T1 - Clinical significance of diffusion tensor tractography as a predictor of functional recovery after laminoplasty in patients with cervical compressive myelopathy

AU - Nakamura, Masaya

AU - Fujiyoshi, Kanehiro

AU - Tsuji, Osahiko

AU - Konomi, Tsunehiko

AU - Hosogane, Naobumi

AU - Watanabe, Kota

AU - Tsuji, Takashi

AU - Ishii, Ken

AU - Momoshima, Suketaka

AU - Toyama, Yoshiaki

AU - Chiba, Kazuhiro

AU - Matsumoto, Morio

PY - 2012/8/1

Y1 - 2012/8/1

N2 - Object. This study was conducted to determine whether postoperative changes in the fractional anisotropy (FA) value and diffusion tensor imaging of the cervical spinal cord can predict functional outcome for patients with cervical compressive myelopathy (CCM). Methods. Twenty patients with CCM were treated by laminoplasty from 2008 to 2009. Both T2-weighted MRI and diffusion tensor imaging were performed before and after surgery. The FA values were analyzed and fiber tracking was performed. The fiber tract (FT) ratio was calculated according to the following formula: (number of fibers at the compressed level)/(number of fibers at the C-2 level) x 100%. The Japanese Orthopaedic Association scoring system for cervical myelopathy was used to determine pre- and postoperative neurological status of the patients, and the Hirabayashi method was used to calculate the recovery rate. Results. There was no significant difference in recovery rates between patients with and those without intramedullary high signal intensity on preoperative T2-weighted images. Substantial differences in FA value among spinal cord, bone, and CSF made it difficult to obtain a precise FA value for the compressed spinal cord. There was a significant correlation between the preoperative FT ratio and the recovery rate (p = 0.0006). A poor outcome (recovery rate < 40%) could be anticipated for CCM patients with preoperative FT ratios below 60%. Conclusions. The preoperative FT ratio correlated significantly with the recovery rates in CCM patients. Preoperative diffusion tensor tractography can be a new prognostic predictor for neurological recovery in CCM patients after laminoplasty.

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