Clinical significance of hepatocyte growth factor and c-Met expression in extrahepatic biliary tract cancers.

Y. Hida; T. Morita; M. Fujita; Y. Miyasaka; S. Horita; Y. Fujioka; K. Nagashima; H. Katoh

doi:10.3892/or.6.5.1051

Clinical significance of hepatocyte growth factor and c-Met expression in extrahepatic biliary tract cancers.

Y. Hida, T. Morita, M. Fujita, Y. Miyasaka, S. Horita, Y. Fujioka, K. Nagashima, H. Katoh

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

Hepatocyte growth factor (HGF)/c-Met expression is known to be correlated with poor prognosis in several cancers. We investigated HGF/c-Met immunoreactivity and its correlation with clinical features in 51 patients with curatively resected extrahepatic biliary tract carcinoma. c-Met showed significant correlations with tumor location, T category, stage, perineural invasion and local recurrence. Overall survival in patients with HGF and c-Met immunopositivity was significantly worse than in those who were negative. Our findings suggest that HGF/c-Met play some roles in tumor development and that HGF/c-Met immunoreactivity could be a predictor of the mode of recurrence and poor prognosis.

Original language	English
Pages (from-to)	1051-1056
Number of pages	6
Journal	Oncology reports
Volume	6
Issue number	5
DOIs	https://doi.org/10.3892/or.6.5.1051
Publication status	Published - 1999
Externally published	Yes

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3892/or.6.5.1051

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title = "Clinical significance of hepatocyte growth factor and c-Met expression in extrahepatic biliary tract cancers.",

abstract = "Hepatocyte growth factor (HGF)/c-Met expression is known to be correlated with poor prognosis in several cancers. We investigated HGF/c-Met immunoreactivity and its correlation with clinical features in 51 patients with curatively resected extrahepatic biliary tract carcinoma. c-Met showed significant correlations with tumor location, T category, stage, perineural invasion and local recurrence. Overall survival in patients with HGF and c-Met immunopositivity was significantly worse than in those who were negative. Our findings suggest that HGF/c-Met play some roles in tumor development and that HGF/c-Met immunoreactivity could be a predictor of the mode of recurrence and poor prognosis.",

author = "Y. Hida and T. Morita and M. Fujita and Y. Miyasaka and S. Horita and Y. Fujioka and K. Nagashima and H. Katoh",

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T1 - Clinical significance of hepatocyte growth factor and c-Met expression in extrahepatic biliary tract cancers.

AU - Hida, Y.

AU - Morita, T.

AU - Fujita, M.

AU - Miyasaka, Y.

AU - Horita, S.

AU - Fujioka, Y.

AU - Nagashima, K.

AU - Katoh, H.

PY - 1999

Y1 - 1999

N2 - Hepatocyte growth factor (HGF)/c-Met expression is known to be correlated with poor prognosis in several cancers. We investigated HGF/c-Met immunoreactivity and its correlation with clinical features in 51 patients with curatively resected extrahepatic biliary tract carcinoma. c-Met showed significant correlations with tumor location, T category, stage, perineural invasion and local recurrence. Overall survival in patients with HGF and c-Met immunopositivity was significantly worse than in those who were negative. Our findings suggest that HGF/c-Met play some roles in tumor development and that HGF/c-Met immunoreactivity could be a predictor of the mode of recurrence and poor prognosis.

AB - Hepatocyte growth factor (HGF)/c-Met expression is known to be correlated with poor prognosis in several cancers. We investigated HGF/c-Met immunoreactivity and its correlation with clinical features in 51 patients with curatively resected extrahepatic biliary tract carcinoma. c-Met showed significant correlations with tumor location, T category, stage, perineural invasion and local recurrence. Overall survival in patients with HGF and c-Met immunopositivity was significantly worse than in those who were negative. Our findings suggest that HGF/c-Met play some roles in tumor development and that HGF/c-Met immunoreactivity could be a predictor of the mode of recurrence and poor prognosis.

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Clinical significance of hepatocyte growth factor and c-Met expression in extrahepatic biliary tract cancers.

Abstract

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