[Clinical significance of hyaline casts in the new CKD risk classification (KDIGO 2009)].

Mariko Adachi, Masato Hoshi, Seiko Ushimaru, Asami Hayashi, Kentaro Nakamoto, Ayumu Kanbe, Nobuyuki Furuta, Isao Inagaki, Hiroyasu Ito, Mitsuru Seishima

Research output: Contribution to journalArticle

Abstract

Chronic kidney disease (CKD) significantly contributes to the increased number of dialysis patients with end stage renal disease. A new CKD risk classification (KDIGO 2009) established in 2011, which is defined by albuminuria and estimated glomerular filtration rate (eGFR) values, demonstrates the relative risks of CKD in great detail. In this study, we evaluated the clinical significance of urinary casts by categorizing a risk Group 1 to 5 according to the KDIGO 2009 classification. In the high risk CKD group (risk group 3 and over), we found a significantly higher number of patients who had > 100 hyaline casts/whole field (WF) in their urine than those that had < 100 hyaline casts/WF. Further, we determined the diagnostic accuracy for the high risk CKD group when the cutoff value for the number of hyaline casts was set at > or = 100 hyaline casts/WF (sensitivity: 44.7%, specificity: 96.5%). The eGFR value was significantly lower in the group with > or = 100 hyaline casts/WF, particularly in hypertensive patients, than that in the group with < 100 hyaline casts/ WF. Of interest is that the eGFR value was significantly lower in patients with 100-999 hyaline casts/WF and > or = 1,000 hyaline casts/WF than that in patients with < 100 hyaline casts/WF in A1 stage. Thus, our present study suggests that the presence of > or = 100 hyaline casts/WF indicates decreased eGFR, and the urinary casts counting may be important and useful for the screening and early detection of high-risk CKD.

Original languageEnglish
Pages (from-to)104-111
Number of pages8
JournalRinsho byori. The Japanese journal of clinical pathology
Volume61
Issue number2
Publication statusPublished - 01-02-2013

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Hyalin
Chronic Renal Insufficiency
Glomerular Filtration Rate
Albuminuria
Chronic Kidney Failure
Dialysis
Urine
Sensitivity and Specificity

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Adachi, M., Hoshi, M., Ushimaru, S., Hayashi, A., Nakamoto, K., Kanbe, A., ... Seishima, M. (2013). [Clinical significance of hyaline casts in the new CKD risk classification (KDIGO 2009)]. Rinsho byori. The Japanese journal of clinical pathology, 61(2), 104-111.
Adachi, Mariko ; Hoshi, Masato ; Ushimaru, Seiko ; Hayashi, Asami ; Nakamoto, Kentaro ; Kanbe, Ayumu ; Furuta, Nobuyuki ; Inagaki, Isao ; Ito, Hiroyasu ; Seishima, Mitsuru. / [Clinical significance of hyaline casts in the new CKD risk classification (KDIGO 2009)]. In: Rinsho byori. The Japanese journal of clinical pathology. 2013 ; Vol. 61, No. 2. pp. 104-111.
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Adachi, M, Hoshi, M, Ushimaru, S, Hayashi, A, Nakamoto, K, Kanbe, A, Furuta, N, Inagaki, I, Ito, H & Seishima, M 2013, '[Clinical significance of hyaline casts in the new CKD risk classification (KDIGO 2009)].', Rinsho byori. The Japanese journal of clinical pathology, vol. 61, no. 2, pp. 104-111.

[Clinical significance of hyaline casts in the new CKD risk classification (KDIGO 2009)]. / Adachi, Mariko; Hoshi, Masato; Ushimaru, Seiko; Hayashi, Asami; Nakamoto, Kentaro; Kanbe, Ayumu; Furuta, Nobuyuki; Inagaki, Isao; Ito, Hiroyasu; Seishima, Mitsuru.

In: Rinsho byori. The Japanese journal of clinical pathology, Vol. 61, No. 2, 01.02.2013, p. 104-111.

Research output: Contribution to journalArticle

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T1 - [Clinical significance of hyaline casts in the new CKD risk classification (KDIGO 2009)].

AU - Adachi, Mariko

AU - Hoshi, Masato

AU - Ushimaru, Seiko

AU - Hayashi, Asami

AU - Nakamoto, Kentaro

AU - Kanbe, Ayumu

AU - Furuta, Nobuyuki

AU - Inagaki, Isao

AU - Ito, Hiroyasu

AU - Seishima, Mitsuru

PY - 2013/2/1

Y1 - 2013/2/1

N2 - Chronic kidney disease (CKD) significantly contributes to the increased number of dialysis patients with end stage renal disease. A new CKD risk classification (KDIGO 2009) established in 2011, which is defined by albuminuria and estimated glomerular filtration rate (eGFR) values, demonstrates the relative risks of CKD in great detail. In this study, we evaluated the clinical significance of urinary casts by categorizing a risk Group 1 to 5 according to the KDIGO 2009 classification. In the high risk CKD group (risk group 3 and over), we found a significantly higher number of patients who had > 100 hyaline casts/whole field (WF) in their urine than those that had < 100 hyaline casts/WF. Further, we determined the diagnostic accuracy for the high risk CKD group when the cutoff value for the number of hyaline casts was set at > or = 100 hyaline casts/WF (sensitivity: 44.7%, specificity: 96.5%). The eGFR value was significantly lower in the group with > or = 100 hyaline casts/WF, particularly in hypertensive patients, than that in the group with < 100 hyaline casts/ WF. Of interest is that the eGFR value was significantly lower in patients with 100-999 hyaline casts/WF and > or = 1,000 hyaline casts/WF than that in patients with < 100 hyaline casts/WF in A1 stage. Thus, our present study suggests that the presence of > or = 100 hyaline casts/WF indicates decreased eGFR, and the urinary casts counting may be important and useful for the screening and early detection of high-risk CKD.

AB - Chronic kidney disease (CKD) significantly contributes to the increased number of dialysis patients with end stage renal disease. A new CKD risk classification (KDIGO 2009) established in 2011, which is defined by albuminuria and estimated glomerular filtration rate (eGFR) values, demonstrates the relative risks of CKD in great detail. In this study, we evaluated the clinical significance of urinary casts by categorizing a risk Group 1 to 5 according to the KDIGO 2009 classification. In the high risk CKD group (risk group 3 and over), we found a significantly higher number of patients who had > 100 hyaline casts/whole field (WF) in their urine than those that had < 100 hyaline casts/WF. Further, we determined the diagnostic accuracy for the high risk CKD group when the cutoff value for the number of hyaline casts was set at > or = 100 hyaline casts/WF (sensitivity: 44.7%, specificity: 96.5%). The eGFR value was significantly lower in the group with > or = 100 hyaline casts/WF, particularly in hypertensive patients, than that in the group with < 100 hyaline casts/ WF. Of interest is that the eGFR value was significantly lower in patients with 100-999 hyaline casts/WF and > or = 1,000 hyaline casts/WF than that in patients with < 100 hyaline casts/WF in A1 stage. Thus, our present study suggests that the presence of > or = 100 hyaline casts/WF indicates decreased eGFR, and the urinary casts counting may be important and useful for the screening and early detection of high-risk CKD.

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