Clinical significance of MMP-3 in patients with rheumatoid arthritis

comparison with other inflammatory markers(IL-6, IL-8)

Hidetsugu Hamakawa, Masao Takemura, Masao Sato, Ryuki Shinohe, Hirohisa Koishi, Nobuyuki Furuta, Hirotoshi Ohta, Noriko Koike, Naoki Iwamoto, Yasuhiro Yamada, Hisayasu Wada, Kuniaki Saito, Mitsuru Seishima

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We determined serum metalloproteinase-3(MMP-3) and inflammatory cytokine(IL-6, IL-8) levels in patients with rheumatoid arthritis(RA). Sera were obtained from 307 healthy subjects(female 140, male 167), 54 RA patients, and 17 osteoarthritis (OA). The MMP-3 concentrations in healthy female and male were 43.3 +/- 15.3 ng/ml and 90.7 +/- 26.0 ng/ml, respectively. The serum MMP-3 levels in male were significantly higher than those in female (p < 0.0001). MMP-3 levels in RA patients(259.1 +/- 34.2 ng/ml) were significantly higher than OA(43.6 +/- 6.1 ng/ml) or healthy controls. There was a significant correlation between MMP-3 and CRP(r = 0.586), IL-6(r = 0.345) levels in serum. In contrast, no significant correlation was observed between MMP-3 and IL-8(r = 0.19), or CA-RF(r = 0.052) levels. However, there were some cases with high MMP-3 levels in CA-RF-negative patients definitely diagnosed as RA. These findings suggest that MMP-3 determination is useful for the early diagnosis and the follow-up during the treatment for RA patients.

Original languageEnglish
Pages (from-to)13-18
Number of pages6
JournalRinsho byori. The Japanese journal of clinical pathology
Volume51
Issue number1
Publication statusPublished - 01-01-2003
Externally publishedYes

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Matrix Metalloproteinases
Interleukin-8
Interleukin-6
Rheumatoid Arthritis
Serum
Osteoarthritis
Matrix Metalloproteinase 3
Early Diagnosis
Healthy Volunteers
Cytokines

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Hamakawa, Hidetsugu ; Takemura, Masao ; Sato, Masao ; Shinohe, Ryuki ; Koishi, Hirohisa ; Furuta, Nobuyuki ; Ohta, Hirotoshi ; Koike, Noriko ; Iwamoto, Naoki ; Yamada, Yasuhiro ; Wada, Hisayasu ; Saito, Kuniaki ; Seishima, Mitsuru. / Clinical significance of MMP-3 in patients with rheumatoid arthritis : comparison with other inflammatory markers(IL-6, IL-8). In: Rinsho byori. The Japanese journal of clinical pathology. 2003 ; Vol. 51, No. 1. pp. 13-18.
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abstract = "We determined serum metalloproteinase-3(MMP-3) and inflammatory cytokine(IL-6, IL-8) levels in patients with rheumatoid arthritis(RA). Sera were obtained from 307 healthy subjects(female 140, male 167), 54 RA patients, and 17 osteoarthritis (OA). The MMP-3 concentrations in healthy female and male were 43.3 +/- 15.3 ng/ml and 90.7 +/- 26.0 ng/ml, respectively. The serum MMP-3 levels in male were significantly higher than those in female (p < 0.0001). MMP-3 levels in RA patients(259.1 +/- 34.2 ng/ml) were significantly higher than OA(43.6 +/- 6.1 ng/ml) or healthy controls. There was a significant correlation between MMP-3 and CRP(r = 0.586), IL-6(r = 0.345) levels in serum. In contrast, no significant correlation was observed between MMP-3 and IL-8(r = 0.19), or CA-RF(r = 0.052) levels. However, there were some cases with high MMP-3 levels in CA-RF-negative patients definitely diagnosed as RA. These findings suggest that MMP-3 determination is useful for the early diagnosis and the follow-up during the treatment for RA patients.",
author = "Hidetsugu Hamakawa and Masao Takemura and Masao Sato and Ryuki Shinohe and Hirohisa Koishi and Nobuyuki Furuta and Hirotoshi Ohta and Noriko Koike and Naoki Iwamoto and Yasuhiro Yamada and Hisayasu Wada and Kuniaki Saito and Mitsuru Seishima",
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Hamakawa, H, Takemura, M, Sato, M, Shinohe, R, Koishi, H, Furuta, N, Ohta, H, Koike, N, Iwamoto, N, Yamada, Y, Wada, H, Saito, K & Seishima, M 2003, 'Clinical significance of MMP-3 in patients with rheumatoid arthritis: comparison with other inflammatory markers(IL-6, IL-8)', Rinsho byori. The Japanese journal of clinical pathology, vol. 51, no. 1, pp. 13-18.

Clinical significance of MMP-3 in patients with rheumatoid arthritis : comparison with other inflammatory markers(IL-6, IL-8). / Hamakawa, Hidetsugu; Takemura, Masao; Sato, Masao; Shinohe, Ryuki; Koishi, Hirohisa; Furuta, Nobuyuki; Ohta, Hirotoshi; Koike, Noriko; Iwamoto, Naoki; Yamada, Yasuhiro; Wada, Hisayasu; Saito, Kuniaki; Seishima, Mitsuru.

In: Rinsho byori. The Japanese journal of clinical pathology, Vol. 51, No. 1, 01.01.2003, p. 13-18.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Clinical significance of MMP-3 in patients with rheumatoid arthritis

T2 - comparison with other inflammatory markers(IL-6, IL-8)

AU - Hamakawa, Hidetsugu

AU - Takemura, Masao

AU - Sato, Masao

AU - Shinohe, Ryuki

AU - Koishi, Hirohisa

AU - Furuta, Nobuyuki

AU - Ohta, Hirotoshi

AU - Koike, Noriko

AU - Iwamoto, Naoki

AU - Yamada, Yasuhiro

AU - Wada, Hisayasu

AU - Saito, Kuniaki

AU - Seishima, Mitsuru

PY - 2003/1/1

Y1 - 2003/1/1

N2 - We determined serum metalloproteinase-3(MMP-3) and inflammatory cytokine(IL-6, IL-8) levels in patients with rheumatoid arthritis(RA). Sera were obtained from 307 healthy subjects(female 140, male 167), 54 RA patients, and 17 osteoarthritis (OA). The MMP-3 concentrations in healthy female and male were 43.3 +/- 15.3 ng/ml and 90.7 +/- 26.0 ng/ml, respectively. The serum MMP-3 levels in male were significantly higher than those in female (p < 0.0001). MMP-3 levels in RA patients(259.1 +/- 34.2 ng/ml) were significantly higher than OA(43.6 +/- 6.1 ng/ml) or healthy controls. There was a significant correlation between MMP-3 and CRP(r = 0.586), IL-6(r = 0.345) levels in serum. In contrast, no significant correlation was observed between MMP-3 and IL-8(r = 0.19), or CA-RF(r = 0.052) levels. However, there were some cases with high MMP-3 levels in CA-RF-negative patients definitely diagnosed as RA. These findings suggest that MMP-3 determination is useful for the early diagnosis and the follow-up during the treatment for RA patients.

AB - We determined serum metalloproteinase-3(MMP-3) and inflammatory cytokine(IL-6, IL-8) levels in patients with rheumatoid arthritis(RA). Sera were obtained from 307 healthy subjects(female 140, male 167), 54 RA patients, and 17 osteoarthritis (OA). The MMP-3 concentrations in healthy female and male were 43.3 +/- 15.3 ng/ml and 90.7 +/- 26.0 ng/ml, respectively. The serum MMP-3 levels in male were significantly higher than those in female (p < 0.0001). MMP-3 levels in RA patients(259.1 +/- 34.2 ng/ml) were significantly higher than OA(43.6 +/- 6.1 ng/ml) or healthy controls. There was a significant correlation between MMP-3 and CRP(r = 0.586), IL-6(r = 0.345) levels in serum. In contrast, no significant correlation was observed between MMP-3 and IL-8(r = 0.19), or CA-RF(r = 0.052) levels. However, there were some cases with high MMP-3 levels in CA-RF-negative patients definitely diagnosed as RA. These findings suggest that MMP-3 determination is useful for the early diagnosis and the follow-up during the treatment for RA patients.

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