Clinical significance of perineural invasion diagnosed by immunohistochemistry with anti-S100 antibody in Stage I-III colorectal cancer

Yoshifumi Shimada; Tomoki Kido; Hitoshi Kameyama; Mae Nakano; Ryoma Yagi; Yosuke Tajima; Takuma Okamura; Masato Nakano; Masayuki Nagahashi; Takashi Kobayashi; Masahiro Minagawa; Shin ichi Kosugi; Toshifumi Wakai; Yoichi Ajioka

doi:10.1007/s00595-014-1096-9

Clinical significance of perineural invasion diagnosed by immunohistochemistry with anti-S100 antibody in Stage I-III colorectal cancer

Yoshifumi Shimada, Tomoki Kido, Hitoshi Kameyama, Mae Nakano, Ryoma Yagi, Yosuke Tajima, Takuma Okamura, Masato Nakano, Masayuki Nagahashi, Takashi Kobayashi, Masahiro Minagawa, Shin ichi Kosugi, Toshifumi Wakai, Yoichi Ajioka

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Abstract

Purpose: Perineural invasion (PN) diagnosed by hematoxylin-eosin (HE) staining is an important prognostic factor after curative-intent surgery in patients with colorectal cancer. However, the clinical significance of PN diagnosed by immunohistochemistry (IHC) has not been investigated. The present study assessed the clinical significance of PN diagnosed by IHC with an anti-S100 antibody in patients with colorectal cancer. Methods: We retrospectively enrolled 184 consecutive patients with stage I-III colorectal cancer who had undergone curative-intent surgery. We analyzed the absence/presence of PN diagnosed by HE staining (HE-PN) compared to that diagnosed by IHC with the anti-S100 antibody (S100-PN). Potential prognostic factors were identified by univariate and multivariate analyses of the overall and relapse-free survival. The κ statistics were used to assess the inter-observer reproducibility. Results: The incidence of HE-PN and S100-PN among the 184 patients was 60 patients (32.6 %) and 113 patients (61.4 %), respectively (P < 0.001). A multivariate Cox proportional hazards regression model analysis indicated that S100-PN was an independent prognostic factor for both the overall and relapse-free survival. The κ value was 0.77 for S100-PN and 0.47 for HE-PN. Conclusion: PN diagnosed by IHC is an important prognostic factor in patients with colorectal cancer. An inter-observer assessment showed superior judgment reproducibility for S100-PN compared with HE-PN.

Original language	English
Pages (from-to)	1493-1500
Number of pages	8
Journal	Surgery Today
Volume	45
Issue number	12
DOIs	https://doi.org/10.1007/s00595-014-1096-9
Publication status	Published - 01-12-2015

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Surgery

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10.1007/s00595-014-1096-9

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Shimada, Y., Kido, T., Kameyama, H., Nakano, M., Yagi, R., Tajima, Y., Okamura, T., Nakano, M., Nagahashi, M., Kobayashi, T., Minagawa, M., Kosugi, S. I., Wakai, T., & Ajioka, Y. (2015). Clinical significance of perineural invasion diagnosed by immunohistochemistry with anti-S100 antibody in Stage I-III colorectal cancer. Surgery Today, 45(12), 1493-1500. https://doi.org/10.1007/s00595-014-1096-9

@article{30c406f7b79f460997e151c44d8f9ae1,

title = "Clinical significance of perineural invasion diagnosed by immunohistochemistry with anti-S100 antibody in Stage I-III colorectal cancer",

abstract = "Purpose: Perineural invasion (PN) diagnosed by hematoxylin-eosin (HE) staining is an important prognostic factor after curative-intent surgery in patients with colorectal cancer. However, the clinical significance of PN diagnosed by immunohistochemistry (IHC) has not been investigated. The present study assessed the clinical significance of PN diagnosed by IHC with an anti-S100 antibody in patients with colorectal cancer. Methods: We retrospectively enrolled 184 consecutive patients with stage I-III colorectal cancer who had undergone curative-intent surgery. We analyzed the absence/presence of PN diagnosed by HE staining (HE-PN) compared to that diagnosed by IHC with the anti-S100 antibody (S100-PN). Potential prognostic factors were identified by univariate and multivariate analyses of the overall and relapse-free survival. The κ statistics were used to assess the inter-observer reproducibility. Results: The incidence of HE-PN and S100-PN among the 184 patients was 60 patients (32.6 %) and 113 patients (61.4 %), respectively (P < 0.001). A multivariate Cox proportional hazards regression model analysis indicated that S100-PN was an independent prognostic factor for both the overall and relapse-free survival. The κ value was 0.77 for S100-PN and 0.47 for HE-PN. Conclusion: PN diagnosed by IHC is an important prognostic factor in patients with colorectal cancer. An inter-observer assessment showed superior judgment reproducibility for S100-PN compared with HE-PN.",

keywords = "Colorectal cancer, Immunohistochemistry, Perineural invasion, S100",

author = "Yoshifumi Shimada and Tomoki Kido and Hitoshi Kameyama and Mae Nakano and Ryoma Yagi and Yosuke Tajima and Takuma Okamura and Masato Nakano and Masayuki Nagahashi and Takashi Kobayashi and Masahiro Minagawa and Kosugi, {Shin ichi} and Toshifumi Wakai and Yoichi Ajioka",

note = "Publisher Copyright: {\textcopyright} 2014, Springer Japan.",

year = "2015",

month = dec,

day = "1",

doi = "10.1007/s00595-014-1096-9",

language = "English",

volume = "45",

pages = "1493--1500",

journal = "Surgery Today",

issn = "0941-1291",

publisher = "Springer",

number = "12",

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Shimada, Y, Kido, T, Kameyama, H, Nakano, M, Yagi, R, Tajima, Y, Okamura, T, Nakano, M, Nagahashi, M, Kobayashi, T, Minagawa, M, Kosugi, SI, Wakai, T & Ajioka, Y 2015, 'Clinical significance of perineural invasion diagnosed by immunohistochemistry with anti-S100 antibody in Stage I-III colorectal cancer', Surgery Today, vol. 45, no. 12, pp. 1493-1500. https://doi.org/10.1007/s00595-014-1096-9

TY - JOUR

T1 - Clinical significance of perineural invasion diagnosed by immunohistochemistry with anti-S100 antibody in Stage I-III colorectal cancer

AU - Shimada, Yoshifumi

AU - Kido, Tomoki

AU - Kameyama, Hitoshi

AU - Nakano, Mae

AU - Yagi, Ryoma

AU - Tajima, Yosuke

AU - Okamura, Takuma

AU - Nakano, Masato

AU - Nagahashi, Masayuki

AU - Kobayashi, Takashi

AU - Minagawa, Masahiro

AU - Kosugi, Shin ichi

AU - Wakai, Toshifumi

AU - Ajioka, Yoichi

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Purpose: Perineural invasion (PN) diagnosed by hematoxylin-eosin (HE) staining is an important prognostic factor after curative-intent surgery in patients with colorectal cancer. However, the clinical significance of PN diagnosed by immunohistochemistry (IHC) has not been investigated. The present study assessed the clinical significance of PN diagnosed by IHC with an anti-S100 antibody in patients with colorectal cancer. Methods: We retrospectively enrolled 184 consecutive patients with stage I-III colorectal cancer who had undergone curative-intent surgery. We analyzed the absence/presence of PN diagnosed by HE staining (HE-PN) compared to that diagnosed by IHC with the anti-S100 antibody (S100-PN). Potential prognostic factors were identified by univariate and multivariate analyses of the overall and relapse-free survival. The κ statistics were used to assess the inter-observer reproducibility. Results: The incidence of HE-PN and S100-PN among the 184 patients was 60 patients (32.6 %) and 113 patients (61.4 %), respectively (P < 0.001). A multivariate Cox proportional hazards regression model analysis indicated that S100-PN was an independent prognostic factor for both the overall and relapse-free survival. The κ value was 0.77 for S100-PN and 0.47 for HE-PN. Conclusion: PN diagnosed by IHC is an important prognostic factor in patients with colorectal cancer. An inter-observer assessment showed superior judgment reproducibility for S100-PN compared with HE-PN.

AB - Purpose: Perineural invasion (PN) diagnosed by hematoxylin-eosin (HE) staining is an important prognostic factor after curative-intent surgery in patients with colorectal cancer. However, the clinical significance of PN diagnosed by immunohistochemistry (IHC) has not been investigated. The present study assessed the clinical significance of PN diagnosed by IHC with an anti-S100 antibody in patients with colorectal cancer. Methods: We retrospectively enrolled 184 consecutive patients with stage I-III colorectal cancer who had undergone curative-intent surgery. We analyzed the absence/presence of PN diagnosed by HE staining (HE-PN) compared to that diagnosed by IHC with the anti-S100 antibody (S100-PN). Potential prognostic factors were identified by univariate and multivariate analyses of the overall and relapse-free survival. The κ statistics were used to assess the inter-observer reproducibility. Results: The incidence of HE-PN and S100-PN among the 184 patients was 60 patients (32.6 %) and 113 patients (61.4 %), respectively (P < 0.001). A multivariate Cox proportional hazards regression model analysis indicated that S100-PN was an independent prognostic factor for both the overall and relapse-free survival. The κ value was 0.77 for S100-PN and 0.47 for HE-PN. Conclusion: PN diagnosed by IHC is an important prognostic factor in patients with colorectal cancer. An inter-observer assessment showed superior judgment reproducibility for S100-PN compared with HE-PN.

KW - Colorectal cancer

KW - Immunohistochemistry

KW - Perineural invasion

KW - S100

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UR - http://www.scopus.com/inward/citedby.url?scp=84947493967&partnerID=8YFLogxK

U2 - 10.1007/s00595-014-1096-9

DO - 10.1007/s00595-014-1096-9

M3 - Article

C2 - 25502403

AN - SCOPUS:84947493967

SN - 0941-1291

VL - 45

SP - 1493

EP - 1500

JO - Surgery Today

JF - Surgery Today

IS - 12

ER -

Clinical significance of perineural invasion diagnosed by immunohistochemistry with anti-S100 antibody in Stage I-III colorectal cancer

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