Clinical significance of serum hyaluronan levels in systemic sclerosis: Association with disease severity

Ayumi Yoshizaki; Yohei Iwata; Kazuhiro Komura; Toshihide Hara; Fumihide Ogawa; Eiji Muroi; Motoi Takenaka; Kazuhiro Shimizu; Minoru Hasegawa; Manabu Fujimoto; Shinichi Sato

Clinical significance of serum hyaluronan levels in systemic sclerosis: Association with disease severity

Ayumi Yoshizaki, Yohei Iwata, Kazuhiro Komura, Toshihide Hara, Fumihide Ogawa, Eiji Muroi, Motoi Takenaka, Kazuhiro Shimizu, Minoru Hasegawa, Manabu Fujimoto, Shinichi Sato

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

Objective. To determine any clinical association of serum levels of hyaluronan in patients with systemic sclerosis (SSc). Methods. Hyaluronan levels in serum samples from patients with SSc (n = 66) and hyaluronan expression in skin were assessed. Results. Serum hyaluronan levels in SSc patients were higher than those in healthy controls. SSc patients with elevated hyaluronan levels had more frequent involvement of several clinical manifestations and immunological abnormalities compared to those with normal levels. Thus, hyaluronan levels correlated with disease severity. Hyaluronan expression in the sclerotic skin from SSc patients was more intense, relative to expression in normal skin. Conclusion. These results suggest that elevated serum hyaluronan levels are associated with disease severity and immunological abnormalities in patients with SSc. The Journal of Rheumatology

Original language	English
Pages (from-to)	1825-1829
Number of pages	5
Journal	Journal of Rheumatology
Volume	35
Issue number	9
Publication status	Published - 09-2008
Externally published	Yes

All Science Journal Classification (ASJC) codes

Rheumatology
Immunology and Allergy
Immunology

Cite this

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title = "Clinical significance of serum hyaluronan levels in systemic sclerosis: Association with disease severity",

abstract = "Objective. To determine any clinical association of serum levels of hyaluronan in patients with systemic sclerosis (SSc). Methods. Hyaluronan levels in serum samples from patients with SSc (n = 66) and hyaluronan expression in skin were assessed. Results. Serum hyaluronan levels in SSc patients were higher than those in healthy controls. SSc patients with elevated hyaluronan levels had more frequent involvement of several clinical manifestations and immunological abnormalities compared to those with normal levels. Thus, hyaluronan levels correlated with disease severity. Hyaluronan expression in the sclerotic skin from SSc patients was more intense, relative to expression in normal skin. Conclusion. These results suggest that elevated serum hyaluronan levels are associated with disease severity and immunological abnormalities in patients with SSc. The Journal of Rheumatology",

author = "Ayumi Yoshizaki and Yohei Iwata and Kazuhiro Komura and Toshihide Hara and Fumihide Ogawa and Eiji Muroi and Motoi Takenaka and Kazuhiro Shimizu and Minoru Hasegawa and Manabu Fujimoto and Shinichi Sato",

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TY - JOUR

T1 - Clinical significance of serum hyaluronan levels in systemic sclerosis

T2 - Association with disease severity

AU - Yoshizaki, Ayumi

AU - Iwata, Yohei

AU - Komura, Kazuhiro

AU - Hara, Toshihide

AU - Ogawa, Fumihide

AU - Muroi, Eiji

AU - Takenaka, Motoi

AU - Shimizu, Kazuhiro

AU - Hasegawa, Minoru

AU - Fujimoto, Manabu

AU - Sato, Shinichi

PY - 2008/9

Y1 - 2008/9

N2 - Objective. To determine any clinical association of serum levels of hyaluronan in patients with systemic sclerosis (SSc). Methods. Hyaluronan levels in serum samples from patients with SSc (n = 66) and hyaluronan expression in skin were assessed. Results. Serum hyaluronan levels in SSc patients were higher than those in healthy controls. SSc patients with elevated hyaluronan levels had more frequent involvement of several clinical manifestations and immunological abnormalities compared to those with normal levels. Thus, hyaluronan levels correlated with disease severity. Hyaluronan expression in the sclerotic skin from SSc patients was more intense, relative to expression in normal skin. Conclusion. These results suggest that elevated serum hyaluronan levels are associated with disease severity and immunological abnormalities in patients with SSc. The Journal of Rheumatology

AB - Objective. To determine any clinical association of serum levels of hyaluronan in patients with systemic sclerosis (SSc). Methods. Hyaluronan levels in serum samples from patients with SSc (n = 66) and hyaluronan expression in skin were assessed. Results. Serum hyaluronan levels in SSc patients were higher than those in healthy controls. SSc patients with elevated hyaluronan levels had more frequent involvement of several clinical manifestations and immunological abnormalities compared to those with normal levels. Thus, hyaluronan levels correlated with disease severity. Hyaluronan expression in the sclerotic skin from SSc patients was more intense, relative to expression in normal skin. Conclusion. These results suggest that elevated serum hyaluronan levels are associated with disease severity and immunological abnormalities in patients with SSc. The Journal of Rheumatology

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Clinical significance of serum hyaluronan levels in systemic sclerosis: Association with disease severity

Abstract

All Science Journal Classification (ASJC) codes

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