TY - JOUR
T1 - Clinical Significance of Ubiquitin-associated Protein 2-like in Patients with Uterine Cervical Cancer
AU - Yoshida, Kosuke
AU - Kajiyama, Hiroaki
AU - Inami, Eri
AU - Tamauchi, Satoshi
AU - Ikeda, Yoshiki
AU - Yoshikawa, Nobuhisa
AU - Nishino, Kimihiro
AU - Utsumi, Fumi
AU - Niimi, Kaoru
AU - Suzuki, Shiro
AU - Shibata, Kiyosumi
AU - Nawa, Akihiro
AU - Kikkawa, Fumitaka
N1 - Publisher Copyright:
© 2020 International Institute of Anticancer Research. All rights reserved.
PY - 2020
Y1 - 2020
N2 - Background: Ubiquitin-associated protein 2-like (UBAP2L) has been demonstrated to be associated with the progression of multiple types of cancer. However, the function of UBAP2L in uterine cervical cancer remains unclear. Materials and Methods: Between 2005 and 2015, 84 patients who underwent surgery were included in this study. The patients were stratified into two groups on the basis of immunohistochemical staining for UBAP2L, and survival analysis was performed. Moreover, loss-of-function analysis was performed using the cervical cancer cell lines CaSki and SiHa. Results: Based on immunohistochemistry, the overall survival in patients with low UBAP2L expression was significantly longer than that of those with high UBAP2L expression (p=0.045). The in vitro experiment revealed that knockdown of UBAP2L remarkably inhibited cell proliferation in both live cell imaging and the MTS assay. Conclusion: Patients with high UBAP2L expression had unfavorable prognosis and UBAP2L appears to play an important role in proliferation.
AB - Background: Ubiquitin-associated protein 2-like (UBAP2L) has been demonstrated to be associated with the progression of multiple types of cancer. However, the function of UBAP2L in uterine cervical cancer remains unclear. Materials and Methods: Between 2005 and 2015, 84 patients who underwent surgery were included in this study. The patients were stratified into two groups on the basis of immunohistochemical staining for UBAP2L, and survival analysis was performed. Moreover, loss-of-function analysis was performed using the cervical cancer cell lines CaSki and SiHa. Results: Based on immunohistochemistry, the overall survival in patients with low UBAP2L expression was significantly longer than that of those with high UBAP2L expression (p=0.045). The in vitro experiment revealed that knockdown of UBAP2L remarkably inhibited cell proliferation in both live cell imaging and the MTS assay. Conclusion: Patients with high UBAP2L expression had unfavorable prognosis and UBAP2L appears to play an important role in proliferation.
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U2 - 10.21873/invivo.11751
DO - 10.21873/invivo.11751
M3 - Article
C2 - 31882469
AN - SCOPUS:85077252343
SN - 0258-851X
VL - 34
SP - 109
EP - 116
JO - In Vivo
JF - In Vivo
IS - 1
ER -