Clinical study of NM441 on urinary tract infections

Keizo Suzuki, Masaki Horiba, Kiyohito Ishikawa, Yorio Naide, Kiyotaka Hoshinaga, Masanori Yanaoka, Shinobu Kato, Shinichi Ando, Norihiko Okishio, Haruyoshi Asano

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NM441, a new oral quinolone antibiotic, was administered to 74 patients with urinary tract infections at a daily dose of 100~600mg for 3~47 days. The patients evaluable according to the criteria of the Japanese UTI Committee were 60 cases, and the clinical efficacy rates were 100% (11/11) in acute uncomplicated cystitis and 63.3% (31/49) in complicated urinary tract infections. Side effects were observed in a total of 5 cases; headache and nausea in 1 and digestive symptoms in 4. Abnormal laboratory findings were observed in a total of 3 cases; an elevation of GPT in 1, elevations of BUN and serum creatinine in 1 and an elevation of serum creatinine in 1.

Original languageEnglish
Pages (from-to)678-683
Number of pages6
JournalJapanese Journal of Chemotherapy
Issue numberSUPPL. 1
Publication statusPublished - 1996

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)

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    Suzuki, K., Horiba, M., Ishikawa, K., Naide, Y., Hoshinaga, K., Yanaoka, M., Kato, S., Ando, S., Okishio, N., & Asano, H. (1996). Clinical study of NM441 on urinary tract infections. Japanese Journal of Chemotherapy, 44(SUPPL. 1), 678-683.