Clinical utility of swept-source optical coherence tomography angiography for the diagnosis of exudative maculopathy

Ai Fujita Sajiki, Keiko Kataoka, Jun Takeuchi, Hikaru Ota, Yuyako Nakano, Etsuyo Horiguchi, Hiroki Kaneko, Hiroko Terasaki, Yasuki Ito, Koji M. Nishiguchi

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To assess the feasibility of swept-source optical coherence tomography angiography (SS-OCTA) to differentiate macular diseases, including nonpolypoidal macular neovascularization (MNV), polypoidal choroidal vasculopathy (PCV), type 3 MNV, and chronic central serous chorioretinopathy (CSC) without indocyanine green angiography (ICGA). Study design: Retrospective observational study. Methods: This study examined 63 eyes of 63 patients with treatment-naive neovascular age-related macular degeneration (AMD), including 23 eyes with nonpolypoidal MNV, 17 eyes with PCV, and 1 eye with type 3 MNV and 22 eyes with chronic CSC. Two independent retina specialists, blinded to the clinical diagnosis, assessed each case of neovascular AMD and chronic CSC using only B-scan and en face images of SS-OCTA without referring to other examination outcomes. Results: By SS-OCTA alone, 19 eyes were diagnosed with nonpolypoidal MNV, 17 eyes with PCV, 2 eyes with type 3 MNV, and 22 eyes with chronic CSC, indicating high sensitivity (82.6%, 94.1%, 100%, and 100%, respectively) and specificity (100%, 97.8%, 98.4%, and 100%, respectively); however, three eyes could not be diagnosed because of obscure images. The agreement of diagnosis with SS-OCTA alone was high between the two specialists (κ = 0.82). Conclusion: SS-OCTA showed high sensitivity and specificity in the differentiation of nonpolypoidal MNV, PCV, type 3 MNV, and chronic CSC. The differential criteria based on SS-OCTA could be a substitute for the ICGA-based diagnoses.

Original languageEnglish
Pages (from-to)614-620
Number of pages7
JournalJapanese Journal of Ophthalmology
Volume68
Issue number6
DOIs
Publication statusPublished - 11-2024

All Science Journal Classification (ASJC) codes

  • Ophthalmology

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