Clinicopathological study on mucinous carcinoma in colon and rectum

Twenty-nine cases of mucinous carcinoma in the colorectum, except for multiple or fistulae cancer were clinicopathologically compared with 470 cases of well-and 162 cases of moderately-differentiated adenocarcinoma. The depth of invasion was se or more in 78.9% of mucinous carcinoma of colon, and all mucinous carcinoma of rectum invaded as a₁. Node metastases up to the second grade were more often seen in mucinous carcinoma of the colon (44.4%) and the rectum (40.0%) than in the other histologic types. There was no significant difference in the incidence of distant metastasis and peritoneal dissemination between mucinous carcinoma and well-and moderately- differentiated adenocarcinoma. The five-year survival rate of mucinous carcinoma was 53.3% in the colon, and 64.9% in the rectum. Curative A resection rates were 77.8% in the colon, and 80.0% in the rectum. Curative resection was expected for mucinous carcinoma by wide resection and sufficient lymphadenectomy. There was no significant difference in the five- year survival rate between mucinous carcinoma and well-and moderately- differentiated adenocarcinoma. The adjuvant therapy for mucinous carcinoma with Dukes' C was recommended in the colon because the five-year survival rate of Dukes' C (37.5%) was worse in mucinous carcinoma of colon than in well-differentiated adenocarcinoma. More accurate method for diagnosis of mucinous carcinoma was needed because preoperative histological diagnosis was poor in the colon (45.0%) and the rectum (16.0%).