Cloning and sequencing of cDNA encoding mouse GTP cyclohydrolase 1

Takahide Nomura, Hiroshi Ichinose, Chiho Sumi-Ichinose, Hiroko Nomura, Yasumichi Hagino, Keisuke Fujita, Toshiharu Nagatsu

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

A full-length cDNA clone for GTP cyclohydrolase I (EC 3.5.4.16) was isolated from a mouse brain cDNA library by plaque hybridization. The nucleotide sequence determination revealed that the length of the cDNA insert was 994 base pairs. The coding region encoded a protein of 241 amino acid residues with a calculated molecular mass of 27,014 daltons. The deduced amino acid sequence of mouse GTP cyclohydrolase I was found to be highly homologous to rat (96%) and human type 1(89%) enzymes.

Original languageEnglish
Pages (from-to)523-527
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume191
Issue number2
DOIs
Publication statusPublished - 15-03-1993

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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