Cloning and sequencing of cDNA encoding mouse GTP cyclohydrolase 1

Takahide Nomura; Hiroshi Ichinose; Chiho Sumi-Ichinose; Hiroko Nomura; Yasumichi Hagino; Keisuke Fujita; Toshiharu Nagatsu

doi:10.1006/bbrc.1993.1249

Cloning and sequencing of cDNA encoding mouse GTP cyclohydrolase 1

Takahide Nomura, Hiroshi Ichinose, Chiho Sumi-Ichinose, Hiroko Nomura, Yasumichi Hagino, Keisuke Fujita, Toshiharu Nagatsu

Research output: Contribution to journal › Article › peer-review

50 Citations (Scopus)

Abstract

A full-length cDNA clone for GTP cyclohydrolase I (EC 3.5.4.16) was isolated from a mouse brain cDNA library by plaque hybridization. The nucleotide sequence determination revealed that the length of the cDNA insert was 994 base pairs. The coding region encoded a protein of 241 amino acid residues with a calculated molecular mass of 27,014 daltons. The deduced amino acid sequence of mouse GTP cyclohydrolase I was found to be highly homologous to rat (96%) and human type 1(89%) enzymes.

Original language	English
Pages (from-to)	523-527
Number of pages	5
Journal	Biochemical and Biophysical Research Communications
Volume	191
Issue number	2
DOIs	https://doi.org/10.1006/bbrc.1993.1249
Publication status	Published - 15-03-1993
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1006/bbrc.1993.1249

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abstract = "A full-length cDNA clone for GTP cyclohydrolase I (EC 3.5.4.16) was isolated from a mouse brain cDNA library by plaque hybridization. The nucleotide sequence determination revealed that the length of the cDNA insert was 994 base pairs. The coding region encoded a protein of 241 amino acid residues with a calculated molecular mass of 27,014 daltons. The deduced amino acid sequence of mouse GTP cyclohydrolase I was found to be highly homologous to rat (96\%) and human type 1(89\%) enzymes.",

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AU - Nomura, Takahide

AU - Ichinose, Hiroshi

AU - Sumi-Ichinose, Chiho

AU - Nomura, Hiroko

AU - Hagino, Yasumichi

AU - Fujita, Keisuke

AU - Nagatsu, Toshiharu

PY - 1993/3/15

Y1 - 1993/3/15

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AB - A full-length cDNA clone for GTP cyclohydrolase I (EC 3.5.4.16) was isolated from a mouse brain cDNA library by plaque hybridization. The nucleotide sequence determination revealed that the length of the cDNA insert was 994 base pairs. The coding region encoded a protein of 241 amino acid residues with a calculated molecular mass of 27,014 daltons. The deduced amino acid sequence of mouse GTP cyclohydrolase I was found to be highly homologous to rat (96%) and human type 1(89%) enzymes.

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JO - Biochemical and Biophysical Research Communications

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Cloning and sequencing of cDNA encoding mouse GTP cyclohydrolase 1

Abstract

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