Cloning of a novel gene for quinolone resistance from a transferable plasmid in Shigella flexneri 2b

Mami Hata, Masahiro Suzuki, Masakado Matsumoto, Masao Takahashi, Katsuhiko Sato, Shiro Ibe, Kenji Sakae

Research output: Contribution to journalArticlepeer-review

252 Citations (Scopus)

Abstract

A novel gene for quinolone resistance was cloned from a transferable plasmid carried by a clinical isolate of Shigella flexneri 2b that was resistant to fluoroquinolones. The plasmid conferred low-level resistance to quinolones on Escherichia coli HB101. The protein encoded by the gene showed 59% amino acid identity with Qnr.

Original languageEnglish
Pages (from-to)801-803
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume49
Issue number2
DOIs
Publication statusPublished - 02-2005
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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