Clozapine, but not haloperidol, reverses social behavior deficit in mice during withdrawal from chronic phencyclidine treatment

H. Qiao, Y. Noda, H. Kamei, T. Nagai, H. Furukawa, H. Miura, Y. Kayukawa, T. Ohta, T. Nabeshima

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109 Citations (Scopus)

Abstract

Phencyclidine (PCP) reduced social behavior (SB) in a dose- and time-dependent fashion. However, no such SB deficit was observed on repeated treatment with methamphetamine for 14 days. The SB deficit produced by treatment with PCP (10mg/kg/day) for 14 days, which persisted for 28 days after withdrawal, was attenuated by clozapine (10 mg/kg/day) given for 7 days, whereas haloperidol for 7 days had no effect. Clozapine, but not haloperidol, alone at the same treatment dose increased SB in saline-treated mice. These results suggest that the proposed PCP model in mice will provide a tool to test beneficial effects of atypical antipsychotics on social dysfunction in schizophrenia, and contribute to our understanding of the mechanisms by which clozapine improves SB deficit.

Original languageEnglish
Pages (from-to)11-15
Number of pages5
JournalNeuroreport
Volume12
Issue number1
DOIs
Publication statusPublished - 22-01-2001

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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