Cluster of differentiation 36 gene polymorphism (rs1761667) is associated with dietary MUFA intake and hypertension in a Japanese population

Ryosuke Fujii, Asahi Hishida, Koji Suzuki, Nahomi Imaeda, Chiho Goto, Nobuyuki Hamajima, Kenji Wakai, Takaaki Kondo

Research output: Contribution to journalArticle

Abstract

Cluster of differentiation 36 (CD36) is a membrane receptor expressed on a wide variety of human cells. CD36 polymorphisms are reportedly associated with oral fat perception, dietary intake and metabolic disorders. The present study examined associations of two CD36 polymorphisms (rs1761667 and rs1527483) and dietary fat intake, and metabolic phenotypes in a Japanese population. This cross-sectional study was conducted based on clinical information collected from health check-ups in Japan (n 495). Dietary nutrient intake was estimated from a validated short FFQ and adjusted for total energy intake using the residual method. Mean blood pressure was calculated from systolic blood pressure (SBP) and diastolic blood pressure (DBP). Hypertension was defined as SBP ≥ 130 mmHg and/or DBP ≥ 85 mmHg, or use of antihypertensive drugs. Genotyping was performed using PCR with confronting two-pair primers method. Mean age was 63·4 (sd 9·9) years. Individuals with the AA genotype showed higher total fat and MUFA intake (standardised β = 0·110 and 0·087, P = 0·01 and 0·05, respectively) compared with the GG and GA genotypes. For metabolic phenotypes, the AA genotype of rs1761667 had a lower blood pressure compared with the GG genotype (standardised β = -0·123, P = 0·02). Our results suggested that the AA genotype of rs1761667 in the CD36 gene was associated with higher intake of total fat and MUFA and lower risk of hypertension in a Japanese population.

Original languageEnglish
Pages (from-to)1215-1222
Number of pages8
JournalBritish Journal of Nutrition
Volume121
Issue number11
DOIs
Publication statusPublished - 14-06-2019

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Blood Pressure
Hypertension
Population
Genes
Genotype
Dietary Fats
Fats
Phenotype
Energy Intake
Antihypertensive Agents
Japan
Cross-Sectional Studies
Food
Polymerase Chain Reaction
Membranes
Health

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Fujii, Ryosuke ; Hishida, Asahi ; Suzuki, Koji ; Imaeda, Nahomi ; Goto, Chiho ; Hamajima, Nobuyuki ; Wakai, Kenji ; Kondo, Takaaki. / Cluster of differentiation 36 gene polymorphism (rs1761667) is associated with dietary MUFA intake and hypertension in a Japanese population. In: British Journal of Nutrition. 2019 ; Vol. 121, No. 11. pp. 1215-1222.
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Cluster of differentiation 36 gene polymorphism (rs1761667) is associated with dietary MUFA intake and hypertension in a Japanese population. / Fujii, Ryosuke; Hishida, Asahi; Suzuki, Koji; Imaeda, Nahomi; Goto, Chiho; Hamajima, Nobuyuki; Wakai, Kenji; Kondo, Takaaki.

In: British Journal of Nutrition, Vol. 121, No. 11, 14.06.2019, p. 1215-1222.

Research output: Contribution to journalArticle

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AU - Fujii, Ryosuke

AU - Hishida, Asahi

AU - Suzuki, Koji

AU - Imaeda, Nahomi

AU - Goto, Chiho

AU - Hamajima, Nobuyuki

AU - Wakai, Kenji

AU - Kondo, Takaaki

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