Co-administration of adenovirus vector expressing CTLA4-Ig prolongs transgene expression in the brain of mice sensitized with adenovirus

Tetsuya Uchida, Koji Kajiwara, Makoto Ideguchi, Koichi Yoshikawa, Jun Morioka, Michiyasu Suzuki

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

The duration of transgene expression in the brain is known to be shortened by previous sensitization to adenovirus. In order to prolong transgene expression, adenovirus vectors expressing CTLA4-Ig (AdCTLA), which blocks the B7-CD28 co-stimulatory signals required for T-cell activation, were used. Local administration of AdCTLA into the brain suppressed both the cellular and humoral immune responses to adenovirus vectors, and prolonged the duration of transgene expression. AdCTLA may be an effective tool for repeated gene transfer.

Original languageEnglish
Pages (from-to)272-280
Number of pages9
JournalBrain Research
Volume898
Issue number2
DOIs
Publication statusPublished - 20-04-2001
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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