TY - JOUR
T1 - Co-administration of adenovirus vector expressing CTLA4-Ig prolongs transgene expression in the brain of mice sensitized with adenovirus
AU - Uchida, Tetsuya
AU - Kajiwara, Koji
AU - Ideguchi, Makoto
AU - Yoshikawa, Koichi
AU - Morioka, Jun
AU - Suzuki, Michiyasu
PY - 2001/4/20
Y1 - 2001/4/20
N2 - The duration of transgene expression in the brain is known to be shortened by previous sensitization to adenovirus. In order to prolong transgene expression, adenovirus vectors expressing CTLA4-Ig (AdCTLA), which blocks the B7-CD28 co-stimulatory signals required for T-cell activation, were used. Local administration of AdCTLA into the brain suppressed both the cellular and humoral immune responses to adenovirus vectors, and prolonged the duration of transgene expression. AdCTLA may be an effective tool for repeated gene transfer.
AB - The duration of transgene expression in the brain is known to be shortened by previous sensitization to adenovirus. In order to prolong transgene expression, adenovirus vectors expressing CTLA4-Ig (AdCTLA), which blocks the B7-CD28 co-stimulatory signals required for T-cell activation, were used. Local administration of AdCTLA into the brain suppressed both the cellular and humoral immune responses to adenovirus vectors, and prolonged the duration of transgene expression. AdCTLA may be an effective tool for repeated gene transfer.
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U2 - 10.1016/S0006-8993(01)02194-1
DO - 10.1016/S0006-8993(01)02194-1
M3 - Article
C2 - 11306013
AN - SCOPUS:0035917852
VL - 898
SP - 272
EP - 280
JO - Molecular Brain Research
JF - Molecular Brain Research
SN - 0006-8993
IS - 2
ER -