Co-infections of Plasmodium knowlesi, P. falciparum, and P. vivax among humans and Anopheles dirus mosquitoes, Southern Vietnam

Ron P. Marchand, Richard Culleton, Yoshimasa Maeno, Nguyen Tuyen Quang, Shusuke Nakazawa

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

A single Anopheles dirus mosquito carrying sporozoites of Plasmodium knowlesi, P. falciparum, and P. vivax was recently discovered in Khanh Phu, southern Vietnam. Further sampling of humans and mosquitoes in this area during 2009-2010 showed P. knowlesi infections in 32 (26%) persons with malaria (n = 125) and in 31 (43%) sporozoite-positive An. dirus mosquitoes (n = 73). Coinfections of P. knowlesi and P. vivax were predominant in mosquitoes and humans, while single P. knowlesi infections were found only in mosquitoes. P. knowlesi-co-infected patients were largely asymptomatic and were concentrated among ethnic minority families who commonly spend nights in the forest. P. knowlesi carriers were significantly younger than those infected with other malaria parasite species. These results imply that even if human malaria could be eliminated, forests that harbor An. dirus mosquitoes and macaque monkeys will remain a reservoir for the zoonotic transmission of P. knowlesi.

Original languageEnglish
Pages (from-to)1232-1239
Number of pages8
JournalEmerging Infectious Diseases
Volume17
Issue number7
DOIs
Publication statusPublished - 01-07-2011

Fingerprint

Plasmodium knowlesi
Anopheles
Vietnam
Culicidae
Coinfection
Malaria
Sporozoites
Zoonoses
Macaca
Haplorhini
Parasites

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Microbiology (medical)
  • Infectious Diseases

Cite this

Marchand, Ron P. ; Culleton, Richard ; Maeno, Yoshimasa ; Quang, Nguyen Tuyen ; Nakazawa, Shusuke. / Co-infections of Plasmodium knowlesi, P. falciparum, and P. vivax among humans and Anopheles dirus mosquitoes, Southern Vietnam. In: Emerging Infectious Diseases. 2011 ; Vol. 17, No. 7. pp. 1232-1239.
@article{00f14037092b45dca457d6edc71acb7f,
title = "Co-infections of Plasmodium knowlesi, P. falciparum, and P. vivax among humans and Anopheles dirus mosquitoes, Southern Vietnam",
abstract = "A single Anopheles dirus mosquito carrying sporozoites of Plasmodium knowlesi, P. falciparum, and P. vivax was recently discovered in Khanh Phu, southern Vietnam. Further sampling of humans and mosquitoes in this area during 2009-2010 showed P. knowlesi infections in 32 (26{\%}) persons with malaria (n = 125) and in 31 (43{\%}) sporozoite-positive An. dirus mosquitoes (n = 73). Coinfections of P. knowlesi and P. vivax were predominant in mosquitoes and humans, while single P. knowlesi infections were found only in mosquitoes. P. knowlesi-co-infected patients were largely asymptomatic and were concentrated among ethnic minority families who commonly spend nights in the forest. P. knowlesi carriers were significantly younger than those infected with other malaria parasite species. These results imply that even if human malaria could be eliminated, forests that harbor An. dirus mosquitoes and macaque monkeys will remain a reservoir for the zoonotic transmission of P. knowlesi.",
author = "Marchand, {Ron P.} and Richard Culleton and Yoshimasa Maeno and Quang, {Nguyen Tuyen} and Shusuke Nakazawa",
year = "2011",
month = "7",
day = "1",
doi = "10.3201/eid1707.101551",
language = "English",
volume = "17",
pages = "1232--1239",
journal = "Emerging Infectious Diseases",
issn = "1080-6040",
publisher = "Centers for Disease Control and Prevention (CDC)",
number = "7",

}

Co-infections of Plasmodium knowlesi, P. falciparum, and P. vivax among humans and Anopheles dirus mosquitoes, Southern Vietnam. / Marchand, Ron P.; Culleton, Richard; Maeno, Yoshimasa; Quang, Nguyen Tuyen; Nakazawa, Shusuke.

In: Emerging Infectious Diseases, Vol. 17, No. 7, 01.07.2011, p. 1232-1239.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Co-infections of Plasmodium knowlesi, P. falciparum, and P. vivax among humans and Anopheles dirus mosquitoes, Southern Vietnam

AU - Marchand, Ron P.

AU - Culleton, Richard

AU - Maeno, Yoshimasa

AU - Quang, Nguyen Tuyen

AU - Nakazawa, Shusuke

PY - 2011/7/1

Y1 - 2011/7/1

N2 - A single Anopheles dirus mosquito carrying sporozoites of Plasmodium knowlesi, P. falciparum, and P. vivax was recently discovered in Khanh Phu, southern Vietnam. Further sampling of humans and mosquitoes in this area during 2009-2010 showed P. knowlesi infections in 32 (26%) persons with malaria (n = 125) and in 31 (43%) sporozoite-positive An. dirus mosquitoes (n = 73). Coinfections of P. knowlesi and P. vivax were predominant in mosquitoes and humans, while single P. knowlesi infections were found only in mosquitoes. P. knowlesi-co-infected patients were largely asymptomatic and were concentrated among ethnic minority families who commonly spend nights in the forest. P. knowlesi carriers were significantly younger than those infected with other malaria parasite species. These results imply that even if human malaria could be eliminated, forests that harbor An. dirus mosquitoes and macaque monkeys will remain a reservoir for the zoonotic transmission of P. knowlesi.

AB - A single Anopheles dirus mosquito carrying sporozoites of Plasmodium knowlesi, P. falciparum, and P. vivax was recently discovered in Khanh Phu, southern Vietnam. Further sampling of humans and mosquitoes in this area during 2009-2010 showed P. knowlesi infections in 32 (26%) persons with malaria (n = 125) and in 31 (43%) sporozoite-positive An. dirus mosquitoes (n = 73). Coinfections of P. knowlesi and P. vivax were predominant in mosquitoes and humans, while single P. knowlesi infections were found only in mosquitoes. P. knowlesi-co-infected patients were largely asymptomatic and were concentrated among ethnic minority families who commonly spend nights in the forest. P. knowlesi carriers were significantly younger than those infected with other malaria parasite species. These results imply that even if human malaria could be eliminated, forests that harbor An. dirus mosquitoes and macaque monkeys will remain a reservoir for the zoonotic transmission of P. knowlesi.

UR - http://www.scopus.com/inward/record.url?scp=79959883735&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79959883735&partnerID=8YFLogxK

U2 - 10.3201/eid1707.101551

DO - 10.3201/eid1707.101551

M3 - Article

C2 - 21762577

AN - SCOPUS:79959883735

VL - 17

SP - 1232

EP - 1239

JO - Emerging Infectious Diseases

JF - Emerging Infectious Diseases

SN - 1080-6040

IS - 7

ER -