Co-localization of FAM and AF-6, the mammalian homologues of Drosophila faf and canoe, in mouse eye development

Masami Kanai-Azuma; John S. Mattick; Kozo Kaibuchi; Stephen A. Wood

doi:10.1016/S0925-4773(99)00294-4

Co-localization of FAM and AF-6, the mammalian homologues of Drosophila faf and canoe, in mouse eye development

Masami Kanai-Azuma
, John S. Mattick
, Kozo Kaibuchi
, Stephen A. Wood

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

The Drosophila fat facets and canoe genes regulate non-neural cell fate decisions during ommatidium formation. We have shown previously that the FAM (fat facets in mouse) de-ubiquitinating enzyme regulates the function of AF- 6, (mammalian canoe homologue), in the MDCK epithelial cell line (Taya et al., 1998. The Ras target AF-6 is a substrate of the fam deubiquitinating enzyme. J. Cell Biol. 142, 1053-1062). We report here that the expression of the FAM and AF-6 proteins overlaps extensively in the mouse eye from embryogenesis to maturity, especially in the non-neural epithelia including the retinal pigment epithelium, subcapsular epithelium of the lens and corneal epithelium. Expression is not limited to the epithelia however, as FAM and AF-6 also co-localize during lens fibre development as well as in sub-populations of the neural retina. (C) 2000 Elsevier Science Ireland Ltd.

Original language	English
Pages (from-to)	383-386
Number of pages	4
Journal	Mechanisms of Development
Volume	91
Issue number	1-2
DOIs	https://doi.org/10.1016/S0925-4773(99)00294-4
Publication status	Published - 01-03-2000
Externally published	Yes

All Science Journal Classification (ASJC) codes

Embryology
Developmental Biology

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10.1016/S0925-4773(99)00294-4

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@article{733035e4625f4934b0b7fd96370f9fd0,

title = "Co-localization of FAM and AF-6, the mammalian homologues of Drosophila faf and canoe, in mouse eye development",

abstract = "The Drosophila fat facets and canoe genes regulate non-neural cell fate decisions during ommatidium formation. We have shown previously that the FAM (fat facets in mouse) de-ubiquitinating enzyme regulates the function of AF- 6, (mammalian canoe homologue), in the MDCK epithelial cell line (Taya et al., 1998. The Ras target AF-6 is a substrate of the fam deubiquitinating enzyme. J. Cell Biol. 142, 1053-1062). We report here that the expression of the FAM and AF-6 proteins overlaps extensively in the mouse eye from embryogenesis to maturity, especially in the non-neural epithelia including the retinal pigment epithelium, subcapsular epithelium of the lens and corneal epithelium. Expression is not limited to the epithelia however, as FAM and AF-6 also co-localize during lens fibre development as well as in sub-populations of the neural retina. (C) 2000 Elsevier Science Ireland Ltd.",

author = "Masami Kanai-Azuma and Mattick, \{John S.\} and Kozo Kaibuchi and Wood, \{Stephen A.\}",

note = "Funding Information: The authors wish to thank Drs. Yoshiakira Kanai, Toshiya Yamada and Derek Kennedy for their helpful support and Dr. Neil Della for advice and comments on the manuscript. We also wish to thank Ms. Ke-lin Ru and Mr. Paul Addison for their technical support. This work was supported, in part, by an Australian National Health and Medical Research Grant to SAW and JSM.",

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doi = "10.1016/S0925-4773(99)00294-4",

language = "English",

volume = "91",

pages = "383--386",

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AU - Kanai-Azuma, Masami

AU - Mattick, John S.

AU - Kaibuchi, Kozo

AU - Wood, Stephen A.

N1 - Funding Information: The authors wish to thank Drs. Yoshiakira Kanai, Toshiya Yamada and Derek Kennedy for their helpful support and Dr. Neil Della for advice and comments on the manuscript. We also wish to thank Ms. Ke-lin Ru and Mr. Paul Addison for their technical support. This work was supported, in part, by an Australian National Health and Medical Research Grant to SAW and JSM.

PY - 2000/3/1

Y1 - 2000/3/1

N2 - The Drosophila fat facets and canoe genes regulate non-neural cell fate decisions during ommatidium formation. We have shown previously that the FAM (fat facets in mouse) de-ubiquitinating enzyme regulates the function of AF- 6, (mammalian canoe homologue), in the MDCK epithelial cell line (Taya et al., 1998. The Ras target AF-6 is a substrate of the fam deubiquitinating enzyme. J. Cell Biol. 142, 1053-1062). We report here that the expression of the FAM and AF-6 proteins overlaps extensively in the mouse eye from embryogenesis to maturity, especially in the non-neural epithelia including the retinal pigment epithelium, subcapsular epithelium of the lens and corneal epithelium. Expression is not limited to the epithelia however, as FAM and AF-6 also co-localize during lens fibre development as well as in sub-populations of the neural retina. (C) 2000 Elsevier Science Ireland Ltd.

AB - The Drosophila fat facets and canoe genes regulate non-neural cell fate decisions during ommatidium formation. We have shown previously that the FAM (fat facets in mouse) de-ubiquitinating enzyme regulates the function of AF- 6, (mammalian canoe homologue), in the MDCK epithelial cell line (Taya et al., 1998. The Ras target AF-6 is a substrate of the fam deubiquitinating enzyme. J. Cell Biol. 142, 1053-1062). We report here that the expression of the FAM and AF-6 proteins overlaps extensively in the mouse eye from embryogenesis to maturity, especially in the non-neural epithelia including the retinal pigment epithelium, subcapsular epithelium of the lens and corneal epithelium. Expression is not limited to the epithelia however, as FAM and AF-6 also co-localize during lens fibre development as well as in sub-populations of the neural retina. (C) 2000 Elsevier Science Ireland Ltd.

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Co-localization of FAM and AF-6, the mammalian homologues of Drosophila faf and canoe, in mouse eye development

Abstract

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