Cocaine- and Amphetamine-Regulated Transcript

Hiroshi Nagasaki; Yuki Kobayashi; Yumiko Saito

doi:10.1016/B978-0-12-801028-0.00128-8

Cocaine- and Amphetamine-Regulated Transcript

Hiroshi Nagasaki, Yuki Kobayashi, Yumiko Saito

Physiology Ⅰ

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

CART was originally discovered as a transcript upregulated in the rat nucleus accumbens in response to cocaine and amphetamine, and the mRNA is detected in the central, peripheral, and enteric nervous systems, and in endocrine tissues such as pancreatic islet cells. Variable processing by prohormone convertase enzymes gives rise to multiple CART fragments. Among them, CART55–102 and CART62–102 are thought to be the putative active peptides. The CART system has been suggested to play a role in a number of physiological and pathophysiological functions, including regulation of feeding, stress, and pancreatic islet function. Identification of a CART receptor(s) has had an impact on our understanding of brain function and thus on new avenues in treating disorders.

Original language	English
Title of host publication	Handbook of Hormones
Subtitle of host publication	Comparative Endocrinology for Basic and Clinical Research
Publisher	Elsevier
Pages	85,e10C-1-87,e10C-1
ISBN (Electronic)	9780128010280
ISBN (Print)	9780128010679
DOIs	https://doi.org/10.1016/B978-0-12-801028-0.00128-8
Publication status	Published - 01-01-2015

All Science Journal Classification (ASJC) codes

General Medicine

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10.1016/B978-0-12-801028-0.00128-8

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abstract = "CART was originally discovered as a transcript upregulated in the rat nucleus accumbens in response to cocaine and amphetamine, and the mRNA is detected in the central, peripheral, and enteric nervous systems, and in endocrine tissues such as pancreatic islet cells. Variable processing by prohormone convertase enzymes gives rise to multiple CART fragments. Among them, CART55–102 and CART62–102 are thought to be the putative active peptides. The CART system has been suggested to play a role in a number of physiological and pathophysiological functions, including regulation of feeding, stress, and pancreatic islet function. Identification of a CART receptor(s) has had an impact on our understanding of brain function and thus on new avenues in treating disorders.",

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AU - Kobayashi, Yuki

AU - Saito, Yumiko

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AB - CART was originally discovered as a transcript upregulated in the rat nucleus accumbens in response to cocaine and amphetamine, and the mRNA is detected in the central, peripheral, and enteric nervous systems, and in endocrine tissues such as pancreatic islet cells. Variable processing by prohormone convertase enzymes gives rise to multiple CART fragments. Among them, CART55–102 and CART62–102 are thought to be the putative active peptides. The CART system has been suggested to play a role in a number of physiological and pathophysiological functions, including regulation of feeding, stress, and pancreatic islet function. Identification of a CART receptor(s) has had an impact on our understanding of brain function and thus on new avenues in treating disorders.

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Cocaine- and Amphetamine-Regulated Transcript

Abstract

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